FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2590601508> ?p ?o ?g. }

• W2590601508 endingPage "28594" @default.
• W2590601508 startingPage "28588" @default.
• W2590601508 abstract "In the previous study, we generated a rat model of dilated cardiomyopathy (DCM) induced by adriamycin and found that the expression of lncRNA H19 was significantly upregulated in myocardial tissue. The present study was aimed to investigate the potential role of H19 in the pathogenesis of adriamycin-induced DCM. H19 knockdown in the myocardium of DCM rats attenuated cardiomyocyte apoptosis and improved left ventricular structure and function. Adriamycin treatment was associated with elevated H19 and miR-675 expression and increased apoptosis in neonatal cardiomyocytes. Enforced expression of miR-675 was found to induce apoptosis in cardiomyocytes with adriamycin treatment and H19-siRNA transfection. The 3'-untranslated region of PA2G4 was cloned downstream of a luciferase reporter construct and cotransfected into HEK293 cells with miR-675 mimic. The results of luciferase assay showed that PA2G4 was a direct target of miR-675. The expression of PA2G4 was reduced in cardiomyocytes transfected with miR-675 mimic. Moreover, H19 knockdown was found to increase PA2G4 expression and suppress apoptosis in cardiomyocytes exposed to adriamycin. In conclusion, our study suggests that H19/miR-675 axis is involved in the promotion of cardiomyocyte apoptosis by targeting PA2G4, which may provide a new therapeutic strategy for the treatment of adriamycin-induced DCM." @default.
• W2590601508 created "2017-03-03" @default.
• W2590601508 creator A5063843254 @default.
• W2590601508 creator A5066226156 @default.
• W2590601508 creator A5070561281 @default.
• W2590601508 creator A5072076223 @default.
• W2590601508 creator A5075136340 @default.
• W2590601508 date "2017-02-20" @default.
• W2590601508 modified "2023-10-18" @default.
• W2590601508 title "The long non-coding RNA H19 promotes cardiomyocyte apoptosis in dilated cardiomyopathy" @default.
• W2590601508 cites W1977279728 @default.
• W2590601508 cites W2004714113 @default.
• W2590601508 cites W2028205153 @default.
• W2590601508 cites W2042978306 @default.
• W2590601508 cites W2045566232 @default.
• W2590601508 cites W2049243347 @default.
• W2590601508 cites W2055929468 @default.
• W2590601508 cites W2079484054 @default.
• W2590601508 cites W2084304742 @default.
• W2590601508 cites W2087377443 @default.
• W2590601508 cites W2120731490 @default.
• W2590601508 cites W2127161220 @default.
• W2590601508 cites W2143188350 @default.
• W2590601508 cites W2540903348 @default.
• W2590601508 cites W627682445 @default.
• W2590601508 doi "https://doi.org/10.18632/oncotarget.15544" @default.
• W2590601508 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5438674" @default.
• W2590601508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28430627" @default.
• W2590601508 hasPublicationYear "2017" @default.
• W2590601508 type Work @default.
• W2590601508 sameAs 2590601508 @default.
• W2590601508 citedByCount "52" @default.
• W2590601508 countsByYear W25906015082017 @default.
• W2590601508 countsByYear W25906015082018 @default.
• W2590601508 countsByYear W25906015082019 @default.
• W2590601508 countsByYear W25906015082020 @default.
• W2590601508 countsByYear W25906015082021 @default.
• W2590601508 countsByYear W25906015082022 @default.
• W2590601508 countsByYear W25906015082023 @default.
• W2590601508 crossrefType "journal-article" @default.
• W2590601508 hasAuthorship W2590601508A5063843254 @default.
• W2590601508 hasAuthorship W2590601508A5066226156 @default.
• W2590601508 hasAuthorship W2590601508A5070561281 @default.
• W2590601508 hasAuthorship W2590601508A5072076223 @default.
• W2590601508 hasAuthorship W2590601508A5075136340 @default.
• W2590601508 hasBestOaLocation W25906015081 @default.
• W2590601508 hasConcept C104317684 @default.
• W2590601508 hasConcept C105580179 @default.
• W2590601508 hasConcept C111335760 @default.
• W2590601508 hasConcept C126322002 @default.
• W2590601508 hasConcept C127561419 @default.
• W2590601508 hasConcept C145059251 @default.
• W2590601508 hasConcept C153911025 @default.
• W2590601508 hasConcept C170493617 @default.
• W2590601508 hasConcept C173396325 @default.
• W2590601508 hasConcept C174510640 @default.
• W2590601508 hasConcept C185592680 @default.
• W2590601508 hasConcept C190283241 @default.
• W2590601508 hasConcept C2780942790 @default.
• W2590601508 hasConcept C502942594 @default.
• W2590601508 hasConcept C54009773 @default.
• W2590601508 hasConcept C54355233 @default.
• W2590601508 hasConcept C55493867 @default.
• W2590601508 hasConcept C71924100 @default.
• W2590601508 hasConcept C81885089 @default.
• W2590601508 hasConcept C86803240 @default.
• W2590601508 hasConcept C89604277 @default.
• W2590601508 hasConcept C95444343 @default.
• W2590601508 hasConceptScore W2590601508C104317684 @default.
• W2590601508 hasConceptScore W2590601508C105580179 @default.
• W2590601508 hasConceptScore W2590601508C111335760 @default.
• W2590601508 hasConceptScore W2590601508C126322002 @default.
• W2590601508 hasConceptScore W2590601508C127561419 @default.
• W2590601508 hasConceptScore W2590601508C145059251 @default.
• W2590601508 hasConceptScore W2590601508C153911025 @default.
• W2590601508 hasConceptScore W2590601508C170493617 @default.
• W2590601508 hasConceptScore W2590601508C173396325 @default.
• W2590601508 hasConceptScore W2590601508C174510640 @default.
• W2590601508 hasConceptScore W2590601508C185592680 @default.
• W2590601508 hasConceptScore W2590601508C190283241 @default.
• W2590601508 hasConceptScore W2590601508C2780942790 @default.
• W2590601508 hasConceptScore W2590601508C502942594 @default.
• W2590601508 hasConceptScore W2590601508C54009773 @default.
• W2590601508 hasConceptScore W2590601508C54355233 @default.
• W2590601508 hasConceptScore W2590601508C55493867 @default.
• W2590601508 hasConceptScore W2590601508C71924100 @default.
• W2590601508 hasConceptScore W2590601508C81885089 @default.
• W2590601508 hasConceptScore W2590601508C86803240 @default.
• W2590601508 hasConceptScore W2590601508C89604277 @default.
• W2590601508 hasConceptScore W2590601508C95444343 @default.
• W2590601508 hasIssue "17" @default.
• W2590601508 hasLocation W25906015081 @default.
• W2590601508 hasLocation W25906015082 @default.
• W2590601508 hasLocation W25906015083 @default.
• W2590601508 hasLocation W25906015084 @default.
• W2590601508 hasOpenAccess W2590601508 @default.
• W2590601508 hasPrimaryLocation W25906015081 @default.
• W2590601508 hasRelatedWork W1976731363 @default.

• next