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- W2590654364 abstract "11072 Background: Introduction of independent prognostic markers may play a significant role in future treatment of colorectal cancer (CRC). Tissue inhibitor of metalloproteinase 1 (TIMP-1) is a glycoprotein, which acts as an inhibitor of all active matrix metalloproteinases. TIMP-1 can be measured in plasma, and it has previously been shown to carry independent prognostic value in patients with primary CRC. The purpose of the present study was to validate TIMP-1 as a prognostic marker in patients undergoing operation for primary CRC. Methods: In the present prospective study plasma samples were collected before surgery from 323 patients with primary CRC between 2000 and 2003. After collection of all samples TIMP-1 was determined using a thoroughly validated, in-house ELISA method. Recurrence and survival were registered and the association to plasma TIMP-1 levels was studied in a Cox multivariate model including age, disease stage, differentiation, lymphatic and vascular vessel invasion calculating hazard ratios and 95% confidence intervals (HR (95%CI)) for overall survival (OS) and disease free survival (DFS). Results: Three local recurrences and 50 distant metastases were registered in stage I-III patients after a median follow-up time of 5.5 (4–7.5) years. No recurrences were observed in stage I (n=44), while 13 were recorded in stage II (n=134) and 38 in stage III (n=94). Scoring TIMP-1 as a continuous variable on a logarithmic scale, plasma TIMP-1 displayed independent prognostic information for the whole cohort in a multivariable statistical analysis: OS: HR 2.35 (1.51–3.66) and DFS: HR 1.86 (1.12–3.08). Conclusions: Plasma TIMP-1 levels carry strong independent prognostic information for patients with primary CRC. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Abbott Laboratories Abbott Laboratories" @default.
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- W2590654364 date "2008-05-20" @default.
- W2590654364 modified "2023-09-27" @default.
- W2590654364 title "Independent prognostic value of plasma tissue inhibitor of metalloproteinases-1 (TIMP-1) in colorectal cancer: A prospective validation study" @default.
- W2590654364 doi "https://doi.org/10.1200/jco.2008.26.15_suppl.11072" @default.
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