FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2590661540> ?p ?o ?g. }

• W2590661540 endingPage "1040.e5" @default.
• W2590661540 startingPage "1034" @default.
• W2590661540 abstract "ObjectiveTo investigate whether the common variant rs2305957 spanning PLK4 (Polo-like kinase 4) confers risk to embryo development in Northern Chinese Han (CHN) women.DesignGenetic association study.SettingUniversity hospital.Patient(s)A total of 2,015 infertile women who underwent in vitro fertilization (IVF), 530 women with early recurrent miscarriage (ERM), and 600 fertile control women in the CHN population.Intervention(s)Genotyping of rs2305957 was performed by means of high-resolution melting analysis.Main Outcome Measure(s)Blastocyst formation, implantation, early miscarriage, and live birth rates in infertile women; genotype distribution at rs2305957 in ERM case and control subjects.Result(s)In the first cohort of this study, infertile women with AA genotype had a lower blastocyst formation rate than those with AG or GG genotype. No significant differences were observed in implantation rate, early miscarriage rate, or live birth rate among AA, AG, and GG subgroups. In the second cohort, common variant rs2305957 was related to ERM. Genotype frequency differences were also significant in both additive model and dominant model.Conclusion(s)Common variant rs2305957 is associated with blastocyst formation and ERM in CHN women. Further investigations of PLK4 gene during embryo development could be worthwhile. To investigate whether the common variant rs2305957 spanning PLK4 (Polo-like kinase 4) confers risk to embryo development in Northern Chinese Han (CHN) women. Genetic association study. University hospital. A total of 2,015 infertile women who underwent in vitro fertilization (IVF), 530 women with early recurrent miscarriage (ERM), and 600 fertile control women in the CHN population. Genotyping of rs2305957 was performed by means of high-resolution melting analysis. Blastocyst formation, implantation, early miscarriage, and live birth rates in infertile women; genotype distribution at rs2305957 in ERM case and control subjects. In the first cohort of this study, infertile women with AA genotype had a lower blastocyst formation rate than those with AG or GG genotype. No significant differences were observed in implantation rate, early miscarriage rate, or live birth rate among AA, AG, and GG subgroups. In the second cohort, common variant rs2305957 was related to ERM. Genotype frequency differences were also significant in both additive model and dominant model. Common variant rs2305957 is associated with blastocyst formation and ERM in CHN women. Further investigations of PLK4 gene during embryo development could be worthwhile." @default.
• W2590661540 created "2017-03-03" @default.
• W2590661540 creator A5012843699 @default.
• W2590661540 creator A5034896367 @default.
• W2590661540 creator A5039074091 @default.
• W2590661540 creator A5043415956 @default.
• W2590661540 creator A5053855584 @default.
• W2590661540 creator A5058747937 @default.
• W2590661540 creator A5061015930 @default.
• W2590661540 creator A5072797355 @default.
• W2590661540 creator A5089106145 @default.
• W2590661540 date "2017-04-01" @default.
• W2590661540 modified "2023-09-30" @default.
• W2590661540 title "Maternal common variant rs2305957 spanning PLK4 is associated with blastocyst formation and early recurrent miscarriage" @default.
• W2590661540 cites W1529934215 @default.
• W2590661540 cites W1911808035 @default.
• W2590661540 cites W1912663693 @default.
• W2590661540 cites W1936975227 @default.
• W2590661540 cites W1972693751 @default.
• W2590661540 cites W1972817655 @default.
• W2590661540 cites W1975989986 @default.
• W2590661540 cites W1977721021 @default.
• W2590661540 cites W1981238350 @default.
• W2590661540 cites W1987339636 @default.
• W2590661540 cites W1995584270 @default.
• W2590661540 cites W2006547416 @default.
• W2590661540 cites W2010274639 @default.
• W2590661540 cites W2027336843 @default.
• W2590661540 cites W2031652126 @default.
• W2590661540 cites W2036361742 @default.
• W2590661540 cites W2041468829 @default.
• W2590661540 cites W2052060433 @default.
• W2590661540 cites W2052641948 @default.
• W2590661540 cites W2054288757 @default.
• W2590661540 cites W2059706140 @default.
• W2590661540 cites W2073005651 @default.
• W2590661540 cites W2073962586 @default.
• W2590661540 cites W2080349528 @default.
• W2590661540 cites W2088188078 @default.
• W2590661540 cites W2097100969 @default.
• W2590661540 cites W2098131249 @default.
• W2590661540 cites W2104127884 @default.
• W2590661540 cites W2109334201 @default.
• W2590661540 cites W2112385886 @default.
• W2590661540 cites W2153850694 @default.
• W2590661540 cites W2164814768 @default.
• W2590661540 cites W2175576391 @default.
• W2590661540 cites W2290842374 @default.
• W2590661540 cites W2317995388 @default.
• W2590661540 cites W2464633546 @default.
• W2590661540 cites W2531447918 @default.
• W2590661540 cites W2553086699 @default.
• W2590661540 cites W4211211389 @default.
• W2590661540 doi "https://doi.org/10.1016/j.fertnstert.2017.01.006" @default.
• W2590661540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28238495" @default.
• W2590661540 hasPublicationYear "2017" @default.
• W2590661540 type Work @default.
• W2590661540 sameAs 2590661540 @default.
• W2590661540 citedByCount "18" @default.
• W2590661540 countsByYear W25906615402017 @default.
• W2590661540 countsByYear W25906615402018 @default.
• W2590661540 countsByYear W25906615402020 @default.
• W2590661540 countsByYear W25906615402021 @default.
• W2590661540 countsByYear W25906615402022 @default.
• W2590661540 crossrefType "journal-article" @default.
• W2590661540 hasAuthorship W2590661540A5012843699 @default.
• W2590661540 hasAuthorship W2590661540A5034896367 @default.
• W2590661540 hasAuthorship W2590661540A5039074091 @default.
• W2590661540 hasAuthorship W2590661540A5043415956 @default.
• W2590661540 hasAuthorship W2590661540A5053855584 @default.
• W2590661540 hasAuthorship W2590661540A5058747937 @default.
• W2590661540 hasAuthorship W2590661540A5061015930 @default.
• W2590661540 hasAuthorship W2590661540A5072797355 @default.
• W2590661540 hasAuthorship W2590661540A5089106145 @default.
• W2590661540 hasBestOaLocation W25906615401 @default.
• W2590661540 hasConcept C104317684 @default.
• W2590661540 hasConcept C131872663 @default.
• W2590661540 hasConcept C135763542 @default.
• W2590661540 hasConcept C16685009 @default.
• W2590661540 hasConcept C196843134 @default.
• W2590661540 hasConcept C2778177303 @default.
• W2590661540 hasConcept C2778279030 @default.
• W2590661540 hasConcept C2779234561 @default.
• W2590661540 hasConcept C2779245376 @default.
• W2590661540 hasConcept C2780625311 @default.
• W2590661540 hasConcept C2908647359 @default.
• W2590661540 hasConcept C29456083 @default.
• W2590661540 hasConcept C512716672 @default.
• W2590661540 hasConcept C54355233 @default.
• W2590661540 hasConcept C71924100 @default.
• W2590661540 hasConcept C86803240 @default.
• W2590661540 hasConcept C87073359 @default.
• W2590661540 hasConcept C99454951 @default.
• W2590661540 hasConceptScore W2590661540C104317684 @default.
• W2590661540 hasConceptScore W2590661540C131872663 @default.
• W2590661540 hasConceptScore W2590661540C135763542 @default.
• W2590661540 hasConceptScore W2590661540C16685009 @default.
• W2590661540 hasConceptScore W2590661540C196843134 @default.

• next