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• W2590680239 abstract "Ultraviolet light (UV) causes DNA damage that is removed by nucleotide excision repair (NER). UV-induced DNA lesions must be recognized and repaired in nucleosomal DNA, higher order structures of chromatin and within different nuclear sub-compartments. Telomeric DNA is made of short tandem repeats located at the ends of chromosomes and their maintenance is critical to prevent genome instability. In Saccharomyces cerevisiae the chromatin structure of natural telomeres is distinctive and contingent to telomeric DNA sequences. Namely, nucleosomes and Sir proteins form the heterochromatin like structure of X-type telomeres, whereas a more open conformation is present at Y'-type telomeres. It is proposed that there are no nucleosomes on the most distal telomeric repeat DNA, which is bound by a complex of proteins and folded into higher order structure. How these structures affect NER is poorly understood. Our data indicate that the X-type, but not the Y'-type, sub-telomeric chromatin modulates NER, a consequence of Sir protein-dependent nucleosome stability. The telomere terminal complex also prevents NER, however, this effect is largely dependent on the yKu-Sir4 interaction, but Sir2 and Sir3 independent." @default.
• W2590680239 created "2017-03-03" @default.
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• W2590680239 creator A5024171061 @default.
• W2590680239 date "2017-02-21" @default.
• W2590680239 modified "2023-10-02" @default.
• W2590680239 title "Repair of UV-induced DNA lesions in natural Saccharomyces cerevisiae telomeres is moderated by Sir2 and Sir3, and inhibited by yKu–Sir4 interaction" @default.
• W2590680239 cites W1415291272 @default.
• W2590680239 cites W1473224886 @default.
• W2590680239 cites W1489405867 @default.
• W2590680239 cites W1492199221 @default.
• W2590680239 cites W1536757970 @default.
• W2590680239 cites W1543815058 @default.
• W2590680239 cites W1554069754 @default.
• W2590680239 cites W1666624602 @default.
• W2590680239 cites W1808593985 @default.
• W2590680239 cites W1957807898 @default.
• W2590680239 cites W1965268641 @default.
• W2590680239 cites W1966605181 @default.
• W2590680239 cites W1970447674 @default.
• W2590680239 cites W1975614137 @default.
• W2590680239 cites W1983555324 @default.
• W2590680239 cites W1989247292 @default.
• W2590680239 cites W1992350296 @default.
• W2590680239 cites W1999523146 @default.
• W2590680239 cites W2001341996 @default.
• W2590680239 cites W2007710180 @default.
• W2590680239 cites W2020449338 @default.
• W2590680239 cites W2020805433 @default.
• W2590680239 cites W2021432006 @default.
• W2590680239 cites W2024396617 @default.
• W2590680239 cites W2024786312 @default.
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• W2590680239 cites W2039876512 @default.
• W2590680239 cites W2045372653 @default.
• W2590680239 cites W2046082575 @default.
• W2590680239 cites W2047500542 @default.
• W2590680239 cites W2049364400 @default.
• W2590680239 cites W2049509944 @default.
• W2590680239 cites W2058346978 @default.
• W2590680239 cites W2059901912 @default.
• W2590680239 cites W2064100920 @default.
• W2590680239 cites W2072908461 @default.
• W2590680239 cites W2081323649 @default.
• W2590680239 cites W2083487776 @default.
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• W2590680239 cites W2094917306 @default.
• W2590680239 cites W2104255956 @default.
• W2590680239 cites W2105487944 @default.
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• W2590680239 cites W2106448802 @default.
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• W2590680239 cites W2111217339 @default.
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• W2590680239 cites W2140948740 @default.
• W2590680239 cites W2141312910 @default.
• W2590680239 cites W2149424329 @default.
• W2590680239 cites W2149438959 @default.
• W2590680239 cites W2151442351 @default.
• W2590680239 cites W2154933591 @default.
• W2590680239 cites W2156644035 @default.
• W2590680239 cites W2157451489 @default.
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• W2590680239 doi "https://doi.org/10.1093/nar/gkx123" @default.
• W2590680239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5416773" @default.
• W2590680239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28334768" @default.
• W2590680239 hasPublicationYear "2017" @default.
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