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• W2590745316 abstract "MicroRNAs (miRNAs) regulate numerous crucial biological processes in plants. However, information is limited on their involvement in the biosynthesis of specialized metabolites in plants, including Catharanthus roseus that produces a number of pharmaceutically valuable, bioactive terpenoid indole alkaloids (TIAs). Using small RNA-sequencing, we identified 181 conserved and 173 novel miRNAs (cro-miRNAs) in C. roseus seedlings. Genome-wide expression analysis revealed that a set of cro-miRNAs are differentially regulated in response to methyl jasmonate (MeJA). In silico target prediction identified 519 potential cro-miRNA targets that include several auxin response factors (ARFs). The presence of cleaved transcripts of miRNA-targeted ARFs in C. roseus cells was confirmed by Poly(A) Polymerase-Mediated Rapid Amplification of cDNA Ends (PPM-RACE). We showed that auxin (indole acetic acid, IAA) repressed the expression of key TIA pathway genes in C. roseus seedlings. Moreover, we demonstrated that a miRNA-regulated ARF, CrARF16, binds to the promoters of key TIA pathway genes and repress their expression. The C. roseus miRNAome reported here provides a comprehensive account of the cro-miRNA populations, as well as their abundance and expression profiles in response to MeJA. In addition, our findings underscore the importance of miRNAs in posttranscriptional control of the biosynthesis of specialized metabolites." @default.
• W2590745316 created "2017-03-03" @default.
• W2590745316 creator A5015419725 @default.
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• W2590745316 creator A5091055038 @default.
• W2590745316 date "2017-02-22" @default.
• W2590745316 modified "2023-10-01" @default.
• W2590745316 title "The miRNAome of Catharanthus roseus: identification, expression analysis, and potential roles of microRNAs in regulation of terpenoid indole alkaloid biosynthesis" @default.
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• W2590745316 doi "https://doi.org/10.1038/srep43027" @default.
• W2590745316 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5320439" @default.
• W2590745316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28223695" @default.

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