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- W2590906243 abstract "1559 Background: Endometrial cancer is the most frequent extracolonic tumor in women with Lynch syndrome (LS). The aim of this study was to assess adherence to screening of gynecological tumors by women with LS and determine the impact of monitoring and prophylactic surgery in these women. Methods: Between 2005-2008, 91 women with LS were subjected to gynecological examination (GE), transvaginal ultrasound (TVS) and endometrial aspirate (EA). The implementation of screening, its results and prophylactic surgery information were evaluated annually and verified with documentation. We analyzed factors associated with adherence: socioeconomic, clinical, genetic and family history, and the results of screening. Results: Of the 91 women with gynecological follow-up, 78 (85.71%) were performed at least once (GE and ETV). EA was zero, except in 3 women (3.3%) with abnormal TVS. 48 underwent a gynecological screening only once. The average gynecological screening examinations (EG + ETV) performed was 1.4 ± 1.07 (range 0-4). Women at risk without cancer adhered better (58.3% vs 52.5% vs 30.8%, p = 0.028). In addition, there was greater compliance if ≥ 2 first degree relatives were affected with endometrial cancer (80% vs 56.3 and 35.4%, p = 0.009). Socioeconomic status, educational, employment and mutational status had no effect on compliance. 3 (3%) women were diagnosed with endometrial cancer. 2 patients suspected diagnosis of endometrial cancer with the first GE including ETV, and confirmed with EA. The third case was detected by a prophylactic hysterectomy in a woman newly diagnosed with two synchronous colon cancers by screening colonoscopy. This was in the one case who underwent prophylactic surgery, and her endometrial cancer was at an early stage (stage IA). Conclusions: Compliance with the recommendations of gynecological screening was 44%. EA is not performed for screening of endometrial cancer. The number of relatives with endometrial cancer increases the likelihood of adhering to gynecological screening. The identification of a mutation has no effect. The first gynecological screening examination detects a significant number of endometrial cancers; and, in addition, prophylactic hysterectomy detects early stage tumors in women with LS." @default.
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- W2590906243 date "2011-05-20" @default.
- W2590906243 modified "2023-10-14" @default.
- W2590906243 title "Gynecologic cancer screening in women at high risk of Lynch syndrome." @default.
- W2590906243 doi "https://doi.org/10.1200/jco.2011.29.15_suppl.1559" @default.
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