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- W2590932020 abstract "Treatment options for degenerative cerebellar ataxias are currently very limited. A large fraction of such disorders is represented by hereditary cerebellar ataxias, whose familiar transmission facilitates an early diagnosis and may possibly allow to start preventive treatments before the onset of the neurodegeneration and appearance of first symptoms. In spite of the heterogeneous aetiology, histological alterations of ataxias often include the primary degeneration of the cerebellar cortex caused by Purkinje cells (PCs) loss. Thus, approaches aimed at replacing or preserving PCs could represent promising ways of disease management. In the present study, we compared the efficacy of two different preventive strategies, namely cell replacement and motor training. We used tambaleante (tbl) mice as a model for progressive ataxia caused by selective loss of PCs and evaluated the effectiveness of the preventive transplantation of healthy PCs into early postnatal tbl cerebella, in terms of PC replacement and functional preservation. On the other hand, we investigated the effects of motor training on PC survival, cerebellar circuitry and their behavioral correlates. Our results demonstrate that, despite a good survival rate and integration of grafted PCs, the adopted grafting protocol could not alleviate the ataxic symptoms in tbl mice. Conversely, preventive motor training increases PCs survival with a moderate positive impact on the motor phenotype." @default.
- W2590932020 created "2017-03-03" @default.
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- W2590932020 date "2017-06-01" @default.
- W2590932020 modified "2023-10-10" @default.
- W2590932020 title "Preventive motor training but not progenitor grafting ameliorates cerebellar ataxia and deregulated autophagy in tambaleante mice" @default.
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- W2590932020 cites W1690429709 @default.
- W2590932020 cites W178605858 @default.
- W2590932020 cites W1889533143 @default.
- W2590932020 cites W1964143171 @default.
- W2590932020 cites W1964932835 @default.
- W2590932020 cites W1966500739 @default.
- W2590932020 cites W1969712802 @default.
- W2590932020 cites W1973274270 @default.
- W2590932020 cites W1976296246 @default.
- W2590932020 cites W1992722596 @default.
- W2590932020 cites W1995800438 @default.
- W2590932020 cites W1996020959 @default.
- W2590932020 cites W2000680597 @default.
- W2590932020 cites W2004229492 @default.
- W2590932020 cites W2005420024 @default.
- W2590932020 cites W2007326167 @default.
- W2590932020 cites W2012702782 @default.
- W2590932020 cites W2014753251 @default.
- W2590932020 cites W2015241097 @default.
- W2590932020 cites W2017689311 @default.
- W2590932020 cites W2023333383 @default.
- W2590932020 cites W2026823323 @default.
- W2590932020 cites W2028474222 @default.
- W2590932020 cites W2030127666 @default.
- W2590932020 cites W2034233086 @default.
- W2590932020 cites W2037289953 @default.
- W2590932020 cites W2037929996 @default.
- W2590932020 cites W2038387222 @default.
- W2590932020 cites W2043749004 @default.
- W2590932020 cites W2044361250 @default.
- W2590932020 cites W2052463507 @default.
- W2590932020 cites W2058734125 @default.
- W2590932020 cites W2061614102 @default.
- W2590932020 cites W2062451160 @default.
- W2590932020 cites W2064563807 @default.
- W2590932020 cites W2068969996 @default.
- W2590932020 cites W2075460872 @default.
- W2590932020 cites W2075992165 @default.
- W2590932020 cites W2079346730 @default.
- W2590932020 cites W2081287867 @default.
- W2590932020 cites W2084789963 @default.
- W2590932020 cites W2086386368 @default.
- W2590932020 cites W2088793139 @default.
- W2590932020 cites W2090428948 @default.
- W2590932020 cites W2091187766 @default.
- W2590932020 cites W2097356145 @default.
- W2590932020 cites W2100592333 @default.
- W2590932020 cites W2102623650 @default.
- W2590932020 cites W2107277218 @default.
- W2590932020 cites W2114909390 @default.
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- W2590932020 cites W2125814499 @default.
- W2590932020 cites W2144889654 @default.
- W2590932020 cites W2152740277 @default.
- W2590932020 cites W2153540508 @default.
- W2590932020 cites W2159266781 @default.
- W2590932020 cites W2166700886 @default.
- W2590932020 cites W2170252991 @default.
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- W2590932020 cites W2262705777 @default.
- W2590932020 cites W2329107604 @default.
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- W2590932020 doi "https://doi.org/10.1016/j.nbd.2017.02.005" @default.
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