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- W2590949175 abstract "Polyamidoamine (PAMAM) dendrimers is considered a better genetic carrier for its ability to form with DNA a nano-sized polyelectrolyte complex of high stability and dissolubility. The mechanism of PAMAMmediated gene endocytosis has been fairly clear and the researches in vitro have confirmed that PAMAM had high transfection efficiency and low cytotoxicity. The researches in vivo have further confirmed that PAMAM had a potential application foreground in the field of gene therapy including in the prevention and treatment of ewing's sarcoma and pulmonary fibrosis, in heart transplantation, and in the preparation of falciparum malaria vaccine.Key words: Polyamidoamine dendrimers; Carrier; Gene therapy" @default.
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- W2590949175 date "2008-10-28" @default.
- W2590949175 modified "2023-09-25" @default.
- W2590949175 title "Progress in research of polyamidoamine dendrimers as gene carriers" @default.
- W2590949175 doi "https://doi.org/10.3760/cma.j.issn.1673-4181.2008.05.015" @default.
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