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- W2590974448 abstract "e21177 Background: As a highly heterogenous disease, individual variation in non-small cell lung cancer (NSCLC) survival outcome may in part be explained by genomic copy number variations. Here we conducted a study to identify novel genes whose focal copy number variations may correlate with the survival of patients after complete resection of early-stage NSCLC in China. Methods: High-resolution 244 K oligo array comparative genomic hybridization (CGH) was used to analyze DNA from formalin-fixed paraffin-embedded early-stage (IA-IIIA) NSCLC samples. Data of 117 samples passed quality control. Segment cluster value of 0.8 and -1.0 were used as the cut-off value for amplification group and homozygous deletion group according to the user manual of Nexus Copy Number™. Probe distributions of ADAM3A high copy variation samples were checked individually to verify the focal variations. Log rank test was performed to do survival analysis between groups. Kaplan-Meier curve was generated to show survival characteristics. Results: Focal amplification of ADAM3A was detected in 52.1% (61/117) of cases. While homozygous deletion was detected in 6.8% (8/117) of cases. Prognosis of patients with focal amplification of ADAM3A showed no statistical significant difference when compared with normal cohort (median OS 38.8 months versus 40.8 months; p = 0.864). Homozygous deletion of ADAM3A was associated with significantly poorer outcomes than normal cohort (median OS 12.4 months versus 40.8 months; p = 0.000). Prognosis of homozygous deletion group also showed poorer outcomes when compared with focal amplification cohort (median OS 12.4 months versus 38.8 months; p = 0.000). Conclusions: This genome-wide array analysis revealed that focal amplification or homozygous loss of ADAM3A are frequent genetic alterations in early-stage NSCLC. While group of focal amplification and normal group indicated no significant difference in prognosis, homozygous loss of showed to be correlated with poor prognosis in early-stage NSCLC in China. As little is known about ADAM3A except its role in fertilization, further studies are necessary to explore the mechanism for the prognostic impact of ADAM3A in NSCLC." @default.
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- W2590974448 date "2011-05-20" @default.
- W2590974448 modified "2023-09-23" @default.
- W2590974448 title "Homozygous deletion of ADAM3A revealed by genome-wide analysis of early-stage NSCLC in China showed to be correlated with poor prognosis." @default.
- W2590974448 doi "https://doi.org/10.1200/jco.2011.29.15_suppl.e21177" @default.
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