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- W2590977143 abstract "e18074 Background: Non-small cell lung cancer with brain metastasis (BM-NSCLC) shows poor prognosis, shorter median survival time and worse quality of life. The standard therapy for BM-NSCLC is radiotherapy. Elemene Injection with anti-cancer effects is extracted from radix curcumae. Previous researches demonstrate that it can go through the blood brain barrier due to its small molecule. This prospective randomized clinical study is to confirm the effects of radiotherapy combined with Elemene Injection. Methods: 96 BM-NSCLC cases were enrolled (2003-2006) from both the oncology department of Guang’an men Hospital and Beijing Cancer Hospital. The patients were randomly divided into two groups, the treatment group (48 cases) and the control group (48 cases). The treatment group was applied with both radiotherapy and Elemene Injection (400-600mg intravenously everyday for two weeks), while the control group was applied with radiotherapy alone. The treatment lasted for 4 weeks. The clinical symptoms, Karnofsky score and quality of life (QOL) were observed before and after treatment. Results: The effective rate (CR+PR) of the treatment group was 12.76%, and that of the control group was 8.69%. But there was no statistical significance (P=0.178). The main clinical symptoms of both two groups were improved after treatment. There was significantly statistical difference (P=0.000). The improvement rate of the Karnofsky score in treatment group was 46.80%, while that in control group was 13.04%. There was significantly statistical difference (P=0.000). There were no significant differences of the blood routine test, the hepatic and renal function between the two groups before and after treatment. Conclusions: Elemene Injection can increase the efficacy of radiotherapy and improve the QOL of BM-NSCLC without toxicity or side effects." @default.
- W2590977143 created "2017-03-03" @default.
- W2590977143 creator A5063604010 @default.
- W2590977143 date "2011-05-20" @default.
- W2590977143 modified "2023-10-14" @default.
- W2590977143 title "Elemene injection combined with radiotherapy in treatment for non-small cell lung cancer with brain metastasis." @default.
- W2590977143 doi "https://doi.org/10.1200/jco.2011.29.15_suppl.e18074" @default.
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