FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2591030624> ?p ?o ?g. }

• W2591030624 endingPage "23" @default.
• W2591030624 startingPage "12" @default.
• W2591030624 abstract "Endothelial progenitor cells (EPCs) constitute a promising alternative in cardiovascular regenerative medicine due to their assigned role in angiogenesis and vascular repair. In response to injury, EPCs promote vascular remodeling by replacement of damaged endothelial cells and/or by secreting angiogenic factors over the damaged tissue. Nevertheless, such mechanisms need to be further characterized. In the current approach we have evaluated the initial response of early EPCs (eEPCs) from healthy individuals after direct contact with the factors released by carotid arteries complicated with atherosclerotic plaques (AP), in order to understand the mechanisms underlying the neovascularization and remodeling properties assigned to these cells. Herein, we found that the AP secretome stimulated eEPCs proliferation and mobilization ex vivo, and such increase was accompanied by augmented permeability, cell contraction and also an increase of cell-cell adhesion in association with raised vinculin levels. Furthermore, a comparative mass spectrometry analysis of control versus stimulated eEPCs revealed a differential expression of proteins in the AP treated cells, mostly involved in cell migration, proliferation and vascular remodeling. Some of these protein changes were also detected in the eEPCs isolated from atherosclerotic patients compared to eEPCs from healthy donors. We have shown, for the first time, that the AP released factors activate eEPCs ex vivo by inducing their mobilization together with the expression of vasculogenic related markers. The present approach could be taken as a ex vivo model to study the initial activation of vascular cells in atherosclerosis and also to evaluate strategies looking to potentiate the mobilization of EPCs prior to clinical applications." @default.
• W2591030624 created "2017-03-03" @default.
• W2591030624 creator A5001916523 @default.
• W2591030624 creator A5006947975 @default.
• W2591030624 creator A5013176510 @default.
• W2591030624 creator A5016599586 @default.
• W2591030624 creator A5030352734 @default.
• W2591030624 creator A5042850573 @default.
• W2591030624 creator A5045543592 @default.
• W2591030624 creator A5051222612 @default.
• W2591030624 creator A5053603496 @default.
• W2591030624 creator A5058844204 @default.
• W2591030624 creator A5061900424 @default.
• W2591030624 creator A5062978956 @default.
• W2591030624 creator A5063760753 @default.
• W2591030624 creator A5065868209 @default.
• W2591030624 creator A5071429287 @default.
• W2591030624 date "2017-04-01" @default.
• W2591030624 modified "2023-10-01" @default.
• W2591030624 title "The atheroma plaque secretome stimulates the mobilization of endothelial progenitor cells ex vivo" @default.
• W2591030624 cites W1175330241 @default.
• W2591030624 cites W1586474677 @default.
• W2591030624 cites W1926404879 @default.
• W2591030624 cites W1967586814 @default.
• W2591030624 cites W1969874824 @default.
• W2591030624 cites W1975310796 @default.
• W2591030624 cites W1981153918 @default.
• W2591030624 cites W1987898777 @default.
• W2591030624 cites W1990027015 @default.
• W2591030624 cites W1993235364 @default.
• W2591030624 cites W1993236263 @default.
• W2591030624 cites W1999579644 @default.
• W2591030624 cites W2013539124 @default.
• W2591030624 cites W2021467952 @default.
• W2591030624 cites W2027568211 @default.
• W2591030624 cites W2028625260 @default.
• W2591030624 cites W2032652032 @default.
• W2591030624 cites W2041146107 @default.
• W2591030624 cites W2053704719 @default.
• W2591030624 cites W2057335589 @default.
• W2591030624 cites W2061784561 @default.
• W2591030624 cites W2072254192 @default.
• W2591030624 cites W2099837423 @default.
• W2591030624 cites W2106374411 @default.
• W2591030624 cites W2106669300 @default.
• W2591030624 cites W2107554012 @default.
• W2591030624 cites W2107951334 @default.
• W2591030624 cites W2110273912 @default.
• W2591030624 cites W2112545903 @default.
• W2591030624 cites W2116197354 @default.
• W2591030624 cites W2117146949 @default.
• W2591030624 cites W2119910176 @default.
• W2591030624 cites W2127053984 @default.
• W2591030624 cites W2129718198 @default.
• W2591030624 cites W2130761693 @default.
• W2591030624 cites W2131368577 @default.
• W2591030624 cites W2135351988 @default.
• W2591030624 cites W2144705128 @default.
• W2591030624 cites W2144936650 @default.
• W2591030624 cites W2147687016 @default.
• W2591030624 cites W2149873896 @default.
• W2591030624 cites W2157842889 @default.
• W2591030624 cites W2166962558 @default.
• W2591030624 cites W2169932159 @default.
• W2591030624 cites W2308293303 @default.
• W2591030624 cites W2328259700 @default.
• W2591030624 cites W2406197024 @default.
• W2591030624 cites W3152642421 @default.
• W2591030624 doi "https://doi.org/10.1016/j.yjmcc.2017.02.001" @default.
• W2591030624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28223221" @default.
• W2591030624 hasPublicationYear "2017" @default.
• W2591030624 type Work @default.
• W2591030624 sameAs 2591030624 @default.
• W2591030624 citedByCount "12" @default.
• W2591030624 countsByYear W25910306242018 @default.
• W2591030624 countsByYear W25910306242020 @default.
• W2591030624 countsByYear W25910306242021 @default.
• W2591030624 countsByYear W25910306242022 @default.
• W2591030624 crossrefType "journal-article" @default.
• W2591030624 hasAuthorship W2591030624A5001916523 @default.
• W2591030624 hasAuthorship W2591030624A5006947975 @default.
• W2591030624 hasAuthorship W2591030624A5013176510 @default.
• W2591030624 hasAuthorship W2591030624A5016599586 @default.
• W2591030624 hasAuthorship W2591030624A5030352734 @default.
• W2591030624 hasAuthorship W2591030624A5042850573 @default.
• W2591030624 hasAuthorship W2591030624A5045543592 @default.
• W2591030624 hasAuthorship W2591030624A5051222612 @default.
• W2591030624 hasAuthorship W2591030624A5053603496 @default.
• W2591030624 hasAuthorship W2591030624A5058844204 @default.
• W2591030624 hasAuthorship W2591030624A5061900424 @default.
• W2591030624 hasAuthorship W2591030624A5062978956 @default.
• W2591030624 hasAuthorship W2591030624A5063760753 @default.
• W2591030624 hasAuthorship W2591030624A5065868209 @default.
• W2591030624 hasAuthorship W2591030624A5071429287 @default.
• W2591030624 hasConcept C123012128 @default.
• W2591030624 hasConcept C126322002 @default.
• W2591030624 hasConcept C150903083 @default.
• W2591030624 hasConcept C151872237 @default.

• next