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• W2591036808 abstract "Knowledge of brain correlates of postural control is limited by the technical difficulties in performing controlled experiments with currently available neuroimaging methods. Here we present a system that allows the measurement of anticipatory postural adjustment of human legs to be synchronized with the acquisition of functional magnetic resonance imaging data. The device is composed of Magnetic Resonance Imaging (MRI) compatible force sensors able to measure the level of force applied by both feet. We tested the device in a group of healthy young subjects and a group of elderly subjects with Parkinson's disease using an event-related functional MRI (fMRI) experiment design. In both groups the postural behavior inside the magnetic resonance was correlated to the behavior during gait initiation outside the scanner. The system did not produce noticeable imaging artifacts in the data. Healthy young people showed brain activation patterns coherent with movement planning. Parkinson's disease patients demonstrated an altered pattern of activation within the motor circuitry. We concluded that this force measurement system is able to index both normal and abnormal preparation for gait initiation within an fMRI experiment." @default.
• W2591036808 created "2017-03-03" @default.
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• W2591036808 date "2017-02-23" @default.
• W2591036808 modified "2023-10-01" @default.
• W2591036808 title "An fMRI-compatible force measurement system for the evaluation of the neural correlates of step initiation" @default.
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• W2591036808 doi "https://doi.org/10.1038/srep43088" @default.
• W2591036808 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5322382" @default.
• W2591036808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28230070" @default.
• W2591036808 hasPublicationYear "2017" @default.
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