FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2591184738> ?p ?o ?g. }

• W2591184738 endingPage "S86" @default.
• W2591184738 startingPage "S86" @default.
• W2591184738 abstract "BackgroundPatients with end-stage renal disease undergoing haemodialysis are at high risk of sudden cardiac death. Advanced renal disease is associated with cardiac hypertrophy, which increases risk of life-threatening arrhythmias. Using a new MRI technique, T1 mapping, and the blood biomarker brain natriuretic peptide (BNP), we aimed to measure changes in function and structure of the heart muscle during the first year of haemodialysis treatment in the Cardiac Uraemic Fibrosis Detection in Dialysis Patients study.Methods28 adults with kidney disease on haemodialysis within Glasgow, UK, participated in this single-centre observational study. To be eligible for the study patients had to have been on haemodialysis for less than 1 year. Patients with MRI contraindications or who were expected to be on dialysis for less than 6 months were excluded. Primary outcome was volume of myocardial fibrosis (septal T1 time) on MRI at baseline and at 6 months' follow-up. Secondary outcome was change in serum BNP. Patients gave written consent, and ethics approval was given (13/WS/0301). This study is registered with the ISCTRN registry, number ISCTRN99591655.Findings22 patients completed both baseline and follow-up visits. There was no significant change in septal T1 time after 6 months of haemodialysis (septal T1 time baseline 1276·727 ms, follow-up 1271·837 ms). Left ventricular mass index (LVMI) was reduced at follow-up (baseline mean LVMI 78·3 g/m2 [SD 18·2], follow-up 67·9 [19·0]; p<0·0001). Differences in septal T1 times correlated with difference in LVMI (r=0·545, p=0·009). Median BNP did not significantly change between baseline and follow-up (2908 pg/mL [IQR 1639–5215] vs 2274·5 [1550–7055]). Change in LVMI was correlated with baseline BNP (r=0·492, p=0·02). Correlation between change in BNP and difference in septal T1 time was not significant.Interpretation6 months of haemodialysis therapy was associated with significant improvement in left ventricular hypertrophy but no significant change in T1 mapping markers of cardiac fibrosis or BNP. This small study suggests that starting haemodialysis might be associated with changes in myocardial structure. These changes could potentially be linked to control of uraemia, blood pressure, or both, which commonly occur on starting renal replacement therapy.FundingKidney Research UK (Innovation Grant IN02/2013)." @default.
• W2591184738 created "2017-03-03" @default.
• W2591184738 creator A5007829361 @default.
• W2591184738 creator A5032883537 @default.
• W2591184738 creator A5042828582 @default.
• W2591184738 creator A5053103932 @default.
• W2591184738 creator A5073300021 @default.
• W2591184738 creator A5086619709 @default.
• W2591184738 date "2017-02-01" @default.
• W2591184738 modified "2023-09-23" @default.
• W2591184738 title "Heart function and structure during the first year of haemodialysis treatment: Cardiac Uraemic Fibrosis Detection in Dialysis Patients, an observational prospective study" @default.
• W2591184738 doi "https://doi.org/10.1016/s0140-6736(17)30482-8" @default.
• W2591184738 hasPublicationYear "2017" @default.
• W2591184738 type Work @default.
• W2591184738 sameAs 2591184738 @default.
• W2591184738 citedByCount "2" @default.
• W2591184738 countsByYear W25911847382018 @default.
• W2591184738 countsByYear W25911847382020 @default.
• W2591184738 crossrefType "journal-article" @default.
• W2591184738 hasAuthorship W2591184738A5007829361 @default.
• W2591184738 hasAuthorship W2591184738A5032883537 @default.
• W2591184738 hasAuthorship W2591184738A5042828582 @default.
• W2591184738 hasAuthorship W2591184738A5053103932 @default.
• W2591184738 hasAuthorship W2591184738A5073300021 @default.
• W2591184738 hasAuthorship W2591184738A5086619709 @default.
• W2591184738 hasBestOaLocation W25911847381 @default.
• W2591184738 hasConcept C126322002 @default.
• W2591184738 hasConcept C159641895 @default.
• W2591184738 hasConcept C164705383 @default.
• W2591184738 hasConcept C2775846464 @default.
• W2591184738 hasConcept C2776002628 @default.
• W2591184738 hasConcept C2778063415 @default.
• W2591184738 hasConcept C2778198053 @default.
• W2591184738 hasConcept C2778653478 @default.
• W2591184738 hasConcept C2779978075 @default.
• W2591184738 hasConcept C71924100 @default.
• W2591184738 hasConcept C84393581 @default.
• W2591184738 hasConceptScore W2591184738C126322002 @default.
• W2591184738 hasConceptScore W2591184738C159641895 @default.
• W2591184738 hasConceptScore W2591184738C164705383 @default.
• W2591184738 hasConceptScore W2591184738C2775846464 @default.
• W2591184738 hasConceptScore W2591184738C2776002628 @default.
• W2591184738 hasConceptScore W2591184738C2778063415 @default.
• W2591184738 hasConceptScore W2591184738C2778198053 @default.
• W2591184738 hasConceptScore W2591184738C2778653478 @default.
• W2591184738 hasConceptScore W2591184738C2779978075 @default.
• W2591184738 hasConceptScore W2591184738C71924100 @default.
• W2591184738 hasConceptScore W2591184738C84393581 @default.
• W2591184738 hasLocation W25911847381 @default.
• W2591184738 hasOpenAccess W2591184738 @default.
• W2591184738 hasPrimaryLocation W25911847381 @default.
• W2591184738 hasRelatedWork W118113239 @default.
• W2591184738 hasRelatedWork W2032397571 @default.
• W2591184738 hasRelatedWork W2125804349 @default.
• W2591184738 hasRelatedWork W2153231314 @default.
• W2591184738 hasRelatedWork W2177877461 @default.
• W2591184738 hasRelatedWork W2390396046 @default.
• W2591184738 hasRelatedWork W2408890477 @default.
• W2591184738 hasRelatedWork W3025693780 @default.
• W2591184738 hasRelatedWork W1973944445 @default.
• W2591184738 hasRelatedWork W2184812695 @default.
• W2591184738 hasVolume "389" @default.
• W2591184738 isParatext "false" @default.
• W2591184738 isRetracted "false" @default.
• W2591184738 magId "2591184738" @default.
• W2591184738 workType "article" @default.