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• W2591208855 abstract "10597 Background: The considerable morbidity, mortality and relative rarity of retroperitoneal sarcoma demands an experienced institution to achieve better clinical outcomes. Methods: From the surgical oncology sarcoma database, the charts of 44 patients (pts) with primary retroperitoneal sarcoma from 1989 to 2005 were retrospectively reviewed. Those pts with primary surgery performed at The James Cancer Hospital of The Ohio State University (CHRI) were compared to those who underwent initial surgery at a non-tertiary care center and subsequently were referred for intra-abdominal recurrences. Data were compared with Fisher’s exact test and Student’s t-test where appropriate. Results: Thirty-three pts underwent initial resection of a retroperitoneal sarcoma at CHRI whereas 11 pts underwent initial surgery elsewhere. On univariate analysis, there were no significant differences between the two groups with regard to age, gender, histologic type, grade or disease free interval. Initial surgery at CHRI was more likely to produce an R0 resection (79% vs. 36%, p<0.05) with subsequent negative margins. Preoperative chemoradiation and postoperative chemotherapy were more prevalent for pts treated initially at CHRI than at the outside (36% vs.18%, p>0.05). There was no significant difference in disease-free interval between the two groups from initial surgery to first recurrence (14 mo.s vs. 18 mo.s, p>0.05). Intra-operative radiation (IORT) was utilized in 21 of the 44 pts and had a significant impact on decreasing intra-abdominal recurrence (28% vs. 74% p<0.05). Seven of the 11 pts reoperated on at CHRI underwent IORT with a median follow-up of 30 months. On subgroup analysis, the survival of Grade 1 retroperitoneal sarcomas was significantly better for patients initially operated at CHRI, 61 mo.s vs. 43 mo.s, p<0.05. Hovever, there was no difference in cancer mortality between the two groups (39% vs. 45%, p>0.05). Conclusions: The utilization of multimodality therapy in the initial treatment of retroperitoneal sarcoma was significantly greater in pts treated at CHRI. The surgical therapy resulted in increased R0 resection and decreased intra-abdominal recurrence which led to a greater survival in the subgroup of grade 1 patients. No significant financial relationships to disclose." @default.
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• W2591208855 date "2008-05-20" @default.
• W2591208855 modified "2023-09-27" @default.
• W2591208855 title "The impact of initial surgery at a cancer hospital on the outcome of retroperitoneal sarcomas" @default.
• W2591208855 doi "https://doi.org/10.1200/jco.2008.26.15_suppl.10597" @default.
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