Matches in SemOpenAlex for { <https://semopenalex.org/work/W2591279909> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2591279909 endingPage "5068" @default.
- W2591279909 startingPage "5068" @default.
- W2591279909 abstract "5068 Background: Proteolytic factors of the plasminogen activation system and the human tissue kallikreins (hK4–15) have been implicated in tumor progression in ovarian cancer. Methods: In 142 ovarian cancer patients FIGO 1–4 operated on between 1985 and 1999 in the Dept. of OB&GYN of Munich Technical University (median follow-up 33 months), uPA, PAI-1, hK5–8,10,11,13 were measured by ELISA in primary tumor tissue extracts; 72 patients were optimally debulked. All patients received postoperative platinum-containing chemotherapy. Results: In univariate Cox models of progression free survival (PFS) including these measurements (fractionally ranked) plus age, pN, grading, ascites volume, and residual tumor, the strongest single predictor was presence of residual tumor (HR=4.37; 2.55–7.47). pN (HR=1.94; 1.12–3.38) and ascites volume (HR=2.37; 1.45–3.88) were also separately significant, but none of the others. In multivariate analysis of PFS, residual tumor (HR=4.76; 2.75–8.23) and hK11 (HR=0.30; 0.12–0.77) both entered the model, higher values of hK11 being associated with improved survival. Due to the strong impact of residual tumor on PFS, any factor influencing residual tumor, thus predicting surgical outcome could also be of considerable clinical interest. hK5 and 13 had significant impact on residual tumor. In univariate logistic regression, higher hK5 significantly predicted poor surgical outcome (OR=1.52; 1.25–16.6). In multivariate analysis, both hK5 and hK13 entered the model: Higher hK5 was strongly associated with residual tumor (OR=6.4; 1.63–25.0), whereas higher hK13 was associated with better surgical outcome (OR=0.16; 0.03–0.74). A ROC curve from this model classifies surgical success with AUC=0.65 (0.56–0.75). For OS, residual tumor (HR=8.7; 4.1–18.3) and hK10 (HR=0.21; 0.07–0.64) were significant in multivariate analysis. hK13 (HR=0.27; 0.08–0.85) was significant in univariate analysis only. Higher hK10 and hK13 are associated with better OS. Conclusions: Our results demonstrate that proteolytic factors are linked to tumor aggressiveness in ovarian cancer and have the potential to support clinical therapy decisions. Validation in independent data sets is currently being performed. No significant financial relationships to disclose." @default.
- W2591279909 created "2017-03-03" @default.
- W2591279909 creator A5017728046 @default.
- W2591279909 creator A5022444628 @default.
- W2591279909 creator A5024344215 @default.
- W2591279909 creator A5035167363 @default.
- W2591279909 creator A5051437624 @default.
- W2591279909 creator A5064798782 @default.
- W2591279909 creator A5066989467 @default.
- W2591279909 creator A5071055386 @default.
- W2591279909 creator A5084226800 @default.
- W2591279909 creator A5085601430 @default.
- W2591279909 date "2005-06-01" @default.
- W2591279909 modified "2023-10-14" @default.
- W2591279909 title "Impact of proteolytic factors on surgical success and survival in ovarian cancer" @default.
- W2591279909 doi "https://doi.org/10.1200/jco.2005.23.16_suppl.5068" @default.
- W2591279909 hasPublicationYear "2005" @default.
- W2591279909 type Work @default.
- W2591279909 sameAs 2591279909 @default.
- W2591279909 citedByCount "0" @default.
- W2591279909 crossrefType "journal-article" @default.
- W2591279909 hasAuthorship W2591279909A5017728046 @default.
- W2591279909 hasAuthorship W2591279909A5022444628 @default.
- W2591279909 hasAuthorship W2591279909A5024344215 @default.
- W2591279909 hasAuthorship W2591279909A5035167363 @default.
- W2591279909 hasAuthorship W2591279909A5051437624 @default.
- W2591279909 hasAuthorship W2591279909A5064798782 @default.
- W2591279909 hasAuthorship W2591279909A5066989467 @default.
- W2591279909 hasAuthorship W2591279909A5071055386 @default.
- W2591279909 hasAuthorship W2591279909A5084226800 @default.
- W2591279909 hasAuthorship W2591279909A5085601430 @default.
- W2591279909 hasConcept C121608353 @default.
- W2591279909 hasConcept C126322002 @default.
- W2591279909 hasConcept C143998085 @default.
- W2591279909 hasConcept C144301174 @default.
- W2591279909 hasConcept C18903297 @default.
- W2591279909 hasConcept C2777286243 @default.
- W2591279909 hasConcept C2779256057 @default.
- W2591279909 hasConcept C2780427987 @default.
- W2591279909 hasConcept C2780496750 @default.
- W2591279909 hasConcept C38180746 @default.
- W2591279909 hasConcept C50382708 @default.
- W2591279909 hasConcept C71924100 @default.
- W2591279909 hasConcept C86803240 @default.
- W2591279909 hasConcept C90924648 @default.
- W2591279909 hasConceptScore W2591279909C121608353 @default.
- W2591279909 hasConceptScore W2591279909C126322002 @default.
- W2591279909 hasConceptScore W2591279909C143998085 @default.
- W2591279909 hasConceptScore W2591279909C144301174 @default.
- W2591279909 hasConceptScore W2591279909C18903297 @default.
- W2591279909 hasConceptScore W2591279909C2777286243 @default.
- W2591279909 hasConceptScore W2591279909C2779256057 @default.
- W2591279909 hasConceptScore W2591279909C2780427987 @default.
- W2591279909 hasConceptScore W2591279909C2780496750 @default.
- W2591279909 hasConceptScore W2591279909C38180746 @default.
- W2591279909 hasConceptScore W2591279909C50382708 @default.
- W2591279909 hasConceptScore W2591279909C71924100 @default.
- W2591279909 hasConceptScore W2591279909C86803240 @default.
- W2591279909 hasConceptScore W2591279909C90924648 @default.
- W2591279909 hasIssue "16_suppl" @default.
- W2591279909 hasLocation W25912799091 @default.
- W2591279909 hasOpenAccess W2591279909 @default.
- W2591279909 hasPrimaryLocation W25912799091 @default.
- W2591279909 hasRelatedWork W1972849980 @default.
- W2591279909 hasRelatedWork W1998259048 @default.
- W2591279909 hasRelatedWork W2251065806 @default.
- W2591279909 hasRelatedWork W2361700749 @default.
- W2591279909 hasRelatedWork W2425132249 @default.
- W2591279909 hasRelatedWork W2572375357 @default.
- W2591279909 hasRelatedWork W2906000951 @default.
- W2591279909 hasRelatedWork W4304996051 @default.
- W2591279909 hasRelatedWork W4312772167 @default.
- W2591279909 hasRelatedWork W4361918880 @default.
- W2591279909 hasVolume "23" @default.
- W2591279909 isParatext "false" @default.
- W2591279909 isRetracted "false" @default.
- W2591279909 magId "2591279909" @default.
- W2591279909 workType "article" @default.