Matches in SemOpenAlex for { <https://semopenalex.org/work/W2591293024> ?p ?o ?g. }
- W2591293024 endingPage "e1005345" @default.
- W2591293024 startingPage "e1005345" @default.
- W2591293024 abstract "The search for prostate cancer biomarkers has received increased attention and several DNA repair related enzymes have been linked to this dysfunction. Here we report a targeted search for single nucleotide polymorphisms (SNPs) and functional impact characterization of human ALKBH family dioxygenases related to prostate cancer. Our results uncovered a SNP of ALKBH7, rs7540, which is associated with prostate cancer disease in a statistically significantly manner in two separate cohorts, and maintained in African American men. Comparisons of molecular dynamics (MD) simulations on the wild-type and variant protein structures indicate that the resulting alteration in the enzyme induces a significant structural change that reduces ALKBH7's ability to bind its cosubstrate. Experimental spectroscopy studies with purified proteins validate our MD predictions and corroborate the conclusion that this cancer-associated mutation affects productive cosubstrate binding in ALKBH7." @default.
- W2591293024 created "2017-03-03" @default.
- W2591293024 creator A5009264947 @default.
- W2591293024 creator A5014444186 @default.
- W2591293024 creator A5048229424 @default.
- W2591293024 creator A5065700590 @default.
- W2591293024 creator A5067007014 @default.
- W2591293024 creator A5085956632 @default.
- W2591293024 creator A5088727921 @default.
- W2591293024 date "2017-02-23" @default.
- W2591293024 modified "2023-10-13" @default.
- W2591293024 title "ALKBH7 Variant Related to Prostate Cancer Exhibits Altered Substrate Binding" @default.
- W2591293024 cites W1966949133 @default.
- W2591293024 cites W1968984443 @default.
- W2591293024 cites W1972021276 @default.
- W2591293024 cites W1973234126 @default.
- W2591293024 cites W1976499671 @default.
- W2591293024 cites W1977412270 @default.
- W2591293024 cites W1984516599 @default.
- W2591293024 cites W1984521511 @default.
- W2591293024 cites W1985504836 @default.
- W2591293024 cites W1994941561 @default.
- W2591293024 cites W1999157688 @default.
- W2591293024 cites W2003205776 @default.
- W2591293024 cites W2011758532 @default.
- W2591293024 cites W2012514086 @default.
- W2591293024 cites W2017991488 @default.
- W2591293024 cites W2029245603 @default.
- W2591293024 cites W2029315482 @default.
- W2591293024 cites W2035266068 @default.
- W2591293024 cites W2035687084 @default.
- W2591293024 cites W2044916117 @default.
- W2591293024 cites W2054857816 @default.
- W2591293024 cites W2065283382 @default.
- W2591293024 cites W2069705658 @default.
- W2591293024 cites W2090929626 @default.
- W2591293024 cites W2092309706 @default.
- W2591293024 cites W2095514878 @default.
- W2591293024 cites W2099862393 @default.
- W2591293024 cites W2111662208 @default.
- W2591293024 cites W2120730588 @default.
- W2591293024 cites W2122732537 @default.
- W2591293024 cites W2123764892 @default.
- W2591293024 cites W2132682606 @default.
- W2591293024 cites W2137824047 @default.
- W2591293024 cites W2140882931 @default.
- W2591293024 cites W2144288821 @default.
- W2591293024 cites W2149304706 @default.
- W2591293024 cites W2152061559 @default.
- W2591293024 cites W2154714625 @default.
- W2591293024 cites W2157043398 @default.
- W2591293024 cites W2157971314 @default.
- W2591293024 cites W2164270482 @default.
- W2591293024 cites W2170552969 @default.
- W2591293024 cites W2313116527 @default.
- W2591293024 cites W2315110600 @default.
- W2591293024 cites W2329540625 @default.
- W2591293024 cites W2330354525 @default.
- W2591293024 cites W2413341707 @default.
- W2591293024 cites W2519117091 @default.
- W2591293024 cites W2560742044 @default.
- W2591293024 cites W4255726085 @default.
- W2591293024 cites W70210606 @default.
- W2591293024 doi "https://doi.org/10.1371/journal.pcbi.1005345" @default.
- W2591293024 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5322872" @default.
- W2591293024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28231280" @default.
- W2591293024 hasPublicationYear "2017" @default.
- W2591293024 type Work @default.
- W2591293024 sameAs 2591293024 @default.
- W2591293024 citedByCount "22" @default.
- W2591293024 countsByYear W25912930242017 @default.
- W2591293024 countsByYear W25912930242018 @default.
- W2591293024 countsByYear W25912930242019 @default.
- W2591293024 countsByYear W25912930242020 @default.
- W2591293024 countsByYear W25912930242021 @default.
- W2591293024 countsByYear W25912930242022 @default.
- W2591293024 countsByYear W25912930242023 @default.
- W2591293024 crossrefType "journal-article" @default.
- W2591293024 hasAuthorship W2591293024A5009264947 @default.
- W2591293024 hasAuthorship W2591293024A5014444186 @default.
- W2591293024 hasAuthorship W2591293024A5048229424 @default.
- W2591293024 hasAuthorship W2591293024A5065700590 @default.
- W2591293024 hasAuthorship W2591293024A5067007014 @default.
- W2591293024 hasAuthorship W2591293024A5085956632 @default.
- W2591293024 hasAuthorship W2591293024A5088727921 @default.
- W2591293024 hasBestOaLocation W25912930241 @default.
- W2591293024 hasConcept C104317684 @default.
- W2591293024 hasConcept C121608353 @default.
- W2591293024 hasConcept C135763542 @default.
- W2591293024 hasConcept C139275648 @default.
- W2591293024 hasConcept C153209595 @default.
- W2591293024 hasConcept C181199279 @default.
- W2591293024 hasConcept C2776235491 @default.
- W2591293024 hasConcept C2780192828 @default.
- W2591293024 hasConcept C501734568 @default.
- W2591293024 hasConcept C502942594 @default.
- W2591293024 hasConcept C54355233 @default.
- W2591293024 hasConcept C55493867 @default.