Matches in SemOpenAlex for { <https://semopenalex.org/work/W2591293492> ?p ?o ?g. }
- W2591293492 endingPage "2562" @default.
- W2591293492 startingPage "2557" @default.
- W2591293492 abstract "MicroRNA‑193b (miRNA‑193b) is often differentially expressed and is an important regulator of gene expression in colon cancer. The aim of the present study was to determine whether miRNA‑193b affects cell growth in colon cancer and to investigate the potential underlying mechanisms. Patients with colorectal cancer (CRC; n=20) and healthy volunteers (n=10) were enrolled from the Department of Gastrointestinal Surgery Center, First Affiliated Hospital of Sun Yat‑Sen University (Guangzhou, China). Western blot analysis was used to evaluate the protein expression of SMAD3 and transforming growth factor‑β (TGF‑β) in the patient samples. It was determined that miRNA‑193b expression was markedly elevated in the CRC tissue samples. Furthermore, silencing of miRNA‑193bin SW620 CRC cells by specific inhibitors significantly reduced the cell proliferation and induced apoptosis. In addition, the downregulation of miRNA‑193b significantly activated the protein expression of SMAD3 and TGF‑β, and promoted caspase‑3 activity in SW620 cells. The results of the present study suggested that the deregulation of miRNA‑193b may affect cell growth in colon cancer via the TGF‑β and SMAD3 signaling pathways." @default.
- W2591293492 created "2017-03-03" @default.
- W2591293492 creator A5008421878 @default.
- W2591293492 creator A5021947042 @default.
- W2591293492 creator A5023242097 @default.
- W2591293492 creator A5025185954 @default.
- W2591293492 creator A5076005692 @default.
- W2591293492 creator A5081340408 @default.
- W2591293492 creator A5086645978 @default.
- W2591293492 date "2017-02-22" @default.
- W2591293492 modified "2023-10-15" @default.
- W2591293492 title "Deregulation of miR-193b affects the growth of colon cancer cells via transforming growth factor-β and regulation of the SMAD3 pathway" @default.
- W2591293492 cites W1689593063 @default.
- W2591293492 cites W1760215417 @default.
- W2591293492 cites W1799482054 @default.
- W2591293492 cites W1909809492 @default.
- W2591293492 cites W1918974541 @default.
- W2591293492 cites W1962083355 @default.
- W2591293492 cites W1988103785 @default.
- W2591293492 cites W1990006325 @default.
- W2591293492 cites W1994419931 @default.
- W2591293492 cites W2007353628 @default.
- W2591293492 cites W2016010116 @default.
- W2591293492 cites W2034249826 @default.
- W2591293492 cites W2054173958 @default.
- W2591293492 cites W2070822120 @default.
- W2591293492 cites W2085419928 @default.
- W2591293492 cites W2096332232 @default.
- W2591293492 cites W2099877079 @default.
- W2591293492 cites W2107000161 @default.
- W2591293492 cites W2114993186 @default.
- W2591293492 cites W2115228088 @default.
- W2591293492 cites W2116146866 @default.
- W2591293492 cites W2123413931 @default.
- W2591293492 cites W2125468170 @default.
- W2591293492 cites W2181270875 @default.
- W2591293492 cites W2211545159 @default.
- W2591293492 cites W2233631376 @default.
- W2591293492 cites W2254691024 @default.
- W2591293492 cites W2418164823 @default.
- W2591293492 cites W2517758491 @default.
- W2591293492 cites W2527634451 @default.
- W2591293492 cites W2530085287 @default.
- W2591293492 cites W2553460354 @default.
- W2591293492 doi "https://doi.org/10.3892/ol.2017.5763" @default.
- W2591293492 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5403328" @default.
- W2591293492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28454433" @default.
- W2591293492 hasPublicationYear "2017" @default.
- W2591293492 type Work @default.
- W2591293492 sameAs 2591293492 @default.
- W2591293492 citedByCount "24" @default.
- W2591293492 countsByYear W25912934922017 @default.
- W2591293492 countsByYear W25912934922018 @default.
- W2591293492 countsByYear W25912934922019 @default.
- W2591293492 countsByYear W25912934922020 @default.
- W2591293492 countsByYear W25912934922022 @default.
- W2591293492 countsByYear W25912934922023 @default.
- W2591293492 crossrefType "journal-article" @default.
- W2591293492 hasAuthorship W2591293492A5008421878 @default.
- W2591293492 hasAuthorship W2591293492A5021947042 @default.
- W2591293492 hasAuthorship W2591293492A5023242097 @default.
- W2591293492 hasAuthorship W2591293492A5025185954 @default.
- W2591293492 hasAuthorship W2591293492A5076005692 @default.
- W2591293492 hasAuthorship W2591293492A5081340408 @default.
- W2591293492 hasAuthorship W2591293492A5086645978 @default.
- W2591293492 hasBestOaLocation W25912934921 @default.
- W2591293492 hasConcept C104317684 @default.
- W2591293492 hasConcept C118131993 @default.
- W2591293492 hasConcept C119056186 @default.
- W2591293492 hasConcept C121608353 @default.
- W2591293492 hasConcept C126322002 @default.
- W2591293492 hasConcept C127561419 @default.
- W2591293492 hasConcept C145059251 @default.
- W2591293492 hasConcept C1491633281 @default.
- W2591293492 hasConcept C190283241 @default.
- W2591293492 hasConcept C2781018059 @default.
- W2591293492 hasConcept C29537977 @default.
- W2591293492 hasConcept C502942594 @default.
- W2591293492 hasConcept C526805850 @default.
- W2591293492 hasConcept C54355233 @default.
- W2591293492 hasConcept C62112901 @default.
- W2591293492 hasConcept C62478195 @default.
- W2591293492 hasConcept C67082663 @default.
- W2591293492 hasConcept C71924100 @default.
- W2591293492 hasConcept C86803240 @default.
- W2591293492 hasConcept C95444343 @default.
- W2591293492 hasConceptScore W2591293492C104317684 @default.
- W2591293492 hasConceptScore W2591293492C118131993 @default.
- W2591293492 hasConceptScore W2591293492C119056186 @default.
- W2591293492 hasConceptScore W2591293492C121608353 @default.
- W2591293492 hasConceptScore W2591293492C126322002 @default.
- W2591293492 hasConceptScore W2591293492C127561419 @default.
- W2591293492 hasConceptScore W2591293492C145059251 @default.
- W2591293492 hasConceptScore W2591293492C1491633281 @default.
- W2591293492 hasConceptScore W2591293492C190283241 @default.
- W2591293492 hasConceptScore W2591293492C2781018059 @default.
- W2591293492 hasConceptScore W2591293492C29537977 @default.
- W2591293492 hasConceptScore W2591293492C502942594 @default.