Matches in SemOpenAlex for { <https://semopenalex.org/work/W2591411211> ?p ?o ?g. }
- W2591411211 endingPage "954" @default.
- W2591411211 startingPage "947" @default.
- W2591411211 abstract "Myeloproliferative neoplasms (MPNs) are a group of related clonal hematologic disorders characterized by excess accumulation of one or more myeloid cell lineages and a tendency to transform to acute myeloid leukemia. Deregulated JAK2 signaling has emerged as the central phenotypic driver of BCR -ABL1–negative MPNs and a unifying therapeutic target. In addition, MPNs show unexpected layers of genetic complexity, with multiple abnormalities associated with disease progression, interactions between inherited factors and phenotype driver mutations, and effects related to the order in which mutations are acquired. Although morphology and clinical laboratory analysis continue to play an important role in defining these conditions, genomic analysis is providing a platform for better disease definition, more accurate diagnosis, direction of therapy, and refined prognostication. There is an emerging consensus with regard to many prognostic factors, but there is a clear need to synthesize genomic findings into robust, clinically actionable and widely accepted scoring systems as well as the need to standardize the laboratory methodologies that are used." @default.
- W2591411211 created "2017-03-03" @default.
- W2591411211 creator A5036839901 @default.
- W2591411211 creator A5069571779 @default.
- W2591411211 date "2017-03-20" @default.
- W2591411211 modified "2023-10-16" @default.
- W2591411211 title "Genomics of Myeloproliferative Neoplasms" @default.
- W2591411211 cites W1503482160 @default.
- W2591411211 cites W1626050997 @default.
- W2591411211 cites W1821422107 @default.
- W2591411211 cites W1873488658 @default.
- W2591411211 cites W1963736125 @default.
- W2591411211 cites W1972420606 @default.
- W2591411211 cites W1973494414 @default.
- W2591411211 cites W1978652970 @default.
- W2591411211 cites W1980568348 @default.
- W2591411211 cites W1998367819 @default.
- W2591411211 cites W2007580297 @default.
- W2591411211 cites W2009130073 @default.
- W2591411211 cites W2009902838 @default.
- W2591411211 cites W2013726626 @default.
- W2591411211 cites W2021426948 @default.
- W2591411211 cites W2024401882 @default.
- W2591411211 cites W2026588020 @default.
- W2591411211 cites W2030716854 @default.
- W2591411211 cites W2030868349 @default.
- W2591411211 cites W2033745205 @default.
- W2591411211 cites W2037959451 @default.
- W2591411211 cites W2038345114 @default.
- W2591411211 cites W2041982733 @default.
- W2591411211 cites W2047079894 @default.
- W2591411211 cites W2047897062 @default.
- W2591411211 cites W2048356390 @default.
- W2591411211 cites W2049145190 @default.
- W2591411211 cites W2052451894 @default.
- W2591411211 cites W2056171219 @default.
- W2591411211 cites W2056777053 @default.
- W2591411211 cites W2057838630 @default.
- W2591411211 cites W2059729544 @default.
- W2591411211 cites W2060707701 @default.
- W2591411211 cites W2067978068 @default.
- W2591411211 cites W2072344178 @default.
- W2591411211 cites W2073440691 @default.
- W2591411211 cites W2073726802 @default.
- W2591411211 cites W2077661091 @default.
- W2591411211 cites W2079532825 @default.
- W2591411211 cites W2079800026 @default.
- W2591411211 cites W2083016093 @default.
- W2591411211 cites W2083125488 @default.
- W2591411211 cites W2084050646 @default.
- W2591411211 cites W2084116711 @default.
- W2591411211 cites W2085253297 @default.
- W2591411211 cites W2085404468 @default.
- W2591411211 cites W2085795026 @default.
- W2591411211 cites W2087934326 @default.
- W2591411211 cites W2090885521 @default.
- W2591411211 cites W2093657334 @default.
- W2591411211 cites W2094640639 @default.
- W2591411211 cites W2097743943 @default.
- W2591411211 cites W2098142432 @default.
- W2591411211 cites W2101502003 @default.
- W2591411211 cites W2108771181 @default.
- W2591411211 cites W2112129429 @default.
- W2591411211 cites W2116177105 @default.
- W2591411211 cites W2116878961 @default.
- W2591411211 cites W2121497524 @default.
- W2591411211 cites W2126816979 @default.
- W2591411211 cites W2132394380 @default.
- W2591411211 cites W2133777490 @default.
- W2591411211 cites W2136536098 @default.
- W2591411211 cites W2138709799 @default.
- W2591411211 cites W2144664431 @default.
- W2591411211 cites W2146142395 @default.
- W2591411211 cites W2148965443 @default.
- W2591411211 cites W2149780343 @default.
- W2591411211 cites W2149858388 @default.
- W2591411211 cites W2151027920 @default.
- W2591411211 cites W2155046477 @default.
- W2591411211 cites W2155469435 @default.
- W2591411211 cites W2157394080 @default.
- W2591411211 cites W2157694607 @default.
- W2591411211 cites W2162619595 @default.
- W2591411211 cites W2169405856 @default.
- W2591411211 cites W2169501631 @default.
- W2591411211 cites W2173500616 @default.
- W2591411211 cites W2175028143 @default.
- W2591411211 cites W2176681260 @default.
- W2591411211 cites W2177570048 @default.
- W2591411211 cites W2187320767 @default.
- W2591411211 cites W2230798701 @default.
- W2591411211 cites W2233995368 @default.
- W2591411211 cites W2306779733 @default.
- W2591411211 cites W2326612786 @default.
- W2591411211 cites W2339658711 @default.
- W2591411211 cites W2344384041 @default.
- W2591411211 cites W2354069820 @default.
- W2591411211 cites W2369265668 @default.
- W2591411211 cites W2467728751 @default.