Matches in SemOpenAlex for { <https://semopenalex.org/work/W2591444651> ?p ?o ?g. }
- W2591444651 abstract "Autism spectrum disorder (ASD) is characterized by deficits in sociability and communication, and increased repetitive and/or restrictive behaviours. The etio-pathogenesis is unknown, but overall, ASD has diverse clinical manifestations and has been associated with many possible genetic and environmental factors. As such, it has been a great challenge to identify key neurobiological mechanisms and to develop effective treatments. Current therapies focus on co-morbid conditions (such as epileptic seizures and sleep disturbances) and there is no cure for the core symptoms. Recent studies have increasingly implicated mitochondrial dysfunction. The fact that mitochondria are an integral part of diverse cellular functions and are susceptible to many insults could explain how a wide range of factors can contribute to a consistent behavioral phenotype in ASD. Meanwhile, the high-fat, low-carbohydrate ketogenic diet (KD), used for nearly a century to treat medically intractable epilepsy, has been shown to enhance mitochondrial function through a multiplicity of mechanisms, and to affect additional molecular targets that may address symptoms and comorbidities of ASD. Here, we delineate evidence for the use of metabolism-based therapies such as the KD in the treatment of ASD as well as emerging co-morbid models of epilepsy and autism. Future research directions aimed at validating such therapeutic approaches and identifying additional and novel mechanistic targets are also discussed." @default.
- W2591444651 created "2017-03-03" @default.
- W2591444651 creator A5010085174 @default.
- W2591444651 creator A5018391871 @default.
- W2591444651 creator A5084554132 @default.
- W2591444651 date "2017-02-21" @default.
- W2591444651 modified "2023-10-15" @default.
- W2591444651 title "Metabolic Dysfunction Underlying Autism Spectrum Disorder and Potential Treatment Approaches" @default.
- W2591444651 cites W1168911763 @default.
- W2591444651 cites W1516172702 @default.
- W2591444651 cites W1546165225 @default.
- W2591444651 cites W1546680495 @default.
- W2591444651 cites W15569989 @default.
- W2591444651 cites W1559742681 @default.
- W2591444651 cites W1613369435 @default.
- W2591444651 cites W1759848617 @default.
- W2591444651 cites W1766288982 @default.
- W2591444651 cites W1822193713 @default.
- W2591444651 cites W1827965502 @default.
- W2591444651 cites W1857436308 @default.
- W2591444651 cites W1896608269 @default.
- W2591444651 cites W1917519329 @default.
- W2591444651 cites W1921561313 @default.
- W2591444651 cites W1928496153 @default.
- W2591444651 cites W1931245501 @default.
- W2591444651 cites W1963736913 @default.
- W2591444651 cites W1965241168 @default.
- W2591444651 cites W1965820739 @default.
- W2591444651 cites W1966556786 @default.
- W2591444651 cites W1966717823 @default.
- W2591444651 cites W1969581400 @default.
- W2591444651 cites W1969709153 @default.
- W2591444651 cites W1974297403 @default.
- W2591444651 cites W1974513184 @default.
- W2591444651 cites W1979046783 @default.
- W2591444651 cites W1980765477 @default.
- W2591444651 cites W1983533601 @default.
- W2591444651 cites W1984331840 @default.
- W2591444651 cites W1984713535 @default.
- W2591444651 cites W1984766312 @default.
- W2591444651 cites W1985399895 @default.
- W2591444651 cites W1986863562 @default.
- W2591444651 cites W1993891203 @default.
- W2591444651 cites W1995433618 @default.
- W2591444651 cites W1995530514 @default.
- W2591444651 cites W1998049112 @default.
- W2591444651 cites W1998619221 @default.
- W2591444651 cites W1999766340 @default.
- W2591444651 cites W2001339909 @default.
- W2591444651 cites W2002301998 @default.
- W2591444651 cites W2002780340 @default.
- W2591444651 cites W2004961725 @default.
- W2591444651 cites W2005853038 @default.
- W2591444651 cites W2007115125 @default.
- W2591444651 cites W2010179451 @default.
- W2591444651 cites W2010765482 @default.
- W2591444651 cites W2013303527 @default.
- W2591444651 cites W2013997760 @default.
- W2591444651 cites W2016411894 @default.
- W2591444651 cites W2020430772 @default.
- W2591444651 cites W2020704476 @default.
- W2591444651 cites W2022031092 @default.
- W2591444651 cites W2025395276 @default.
- W2591444651 cites W2027148284 @default.
- W2591444651 cites W2028092741 @default.
- W2591444651 cites W2028169172 @default.
- W2591444651 cites W2029377842 @default.
- W2591444651 cites W2029960467 @default.
- W2591444651 cites W2031102596 @default.
- W2591444651 cites W2031506439 @default.
- W2591444651 cites W2033021653 @default.
- W2591444651 cites W2036216403 @default.
- W2591444651 cites W2038538268 @default.
- W2591444651 cites W2038724272 @default.
- W2591444651 cites W2038750337 @default.
- W2591444651 cites W2041196058 @default.
- W2591444651 cites W2043595793 @default.
- W2591444651 cites W2043701381 @default.
- W2591444651 cites W2045085957 @default.
- W2591444651 cites W2045192866 @default.
- W2591444651 cites W2049045958 @default.
- W2591444651 cites W2050260157 @default.
- W2591444651 cites W2053816494 @default.
- W2591444651 cites W2059378464 @default.
- W2591444651 cites W2060038735 @default.
- W2591444651 cites W2060422855 @default.
- W2591444651 cites W2060836360 @default.
- W2591444651 cites W2062447656 @default.
- W2591444651 cites W2067213832 @default.
- W2591444651 cites W2071797996 @default.
- W2591444651 cites W2073062083 @default.
- W2591444651 cites W2074441804 @default.
- W2591444651 cites W2075567156 @default.
- W2591444651 cites W2077481231 @default.
- W2591444651 cites W2077830280 @default.
- W2591444651 cites W2078824156 @default.
- W2591444651 cites W2079604709 @default.
- W2591444651 cites W2082548421 @default.
- W2591444651 cites W2083252150 @default.
- W2591444651 cites W2083955165 @default.