FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2591470147> ?p ?o ?g. }

• W2591470147 endingPage "403" @default.
• W2591470147 startingPage "403" @default.
• W2591470147 abstract "403 Background: The objective of the present investigation was to assess whether elevated pre-operative CEA level represents a significant predictor for decreased overall survival in stage I-III rectal cancer patients. Methods: The present study is based on the colorectal database of the authors` hospital, one of the largest tertiary care centers of Switzerland. All patients undergoing a resection for stage I - III rectal cancer were consecutively included between 1991 and 2008. Average follow-up time was 50.3 months. The impact of pre-operative CEA on overall survival was assessed in Cox proportional hazard regression analyses after risk-adjusting for age, gender, body mass index, performance status, tumor stage, tumor distance from the anal verge, and neoadjuvant treatment. Pre-operative CEA levels were classified as normal (< 5 µg/liter) versus elevated (>5 µg/liter). All tests were two-sided, the level of statistical significance was set at 0.05. Results: Overall, 534 consecutive patients undergoing resection for stage I - III rectal cancer were included. Median age was 65 years (range 24 to 91 years), 62% of patients were male, median ASA was II (range I – IV), median body mass index 25.3 kg/m 2 (range 15.4 to 44.9 kg/m 2 ). Pre-operative CEA levels were elevated in 21.7% of all patients. After risk-adjusting in Cox proportional hazard regression analyses pre-operative CEA level (p<0.001; odds ratio: 2.020), distance from the anal verge <5cm (p<0.001, odds ratio: 2.434), older age (p<0.001; odds ratio: 1.069) and higher tumor stage (p=0.004, odds ratio: 2.003) were all significant predictors for poor overall survival. Forward- and backward variable selection including bootstrap analyses confirmed these results. Conclusions: The present investigation based on a large cohort of consecutive stage I – III rectal cancer patients provides compelling evidence that elevated pre-operative CEA level is a strong predictor of decreased overall survival even after risk-adjusting in Cox proportional hazard regression analyses. Therefore, it is crucial that pre-operative CEA is used as a prognostic factor in the pre-operative assessment of stage I-III rectal cancer patients." @default.
• W2591470147 created "2017-03-03" @default.
• W2591470147 creator A5025191345 @default.
• W2591470147 creator A5028587740 @default.
• W2591470147 creator A5031240165 @default.
• W2591470147 creator A5037282032 @default.
• W2591470147 creator A5041542671 @default.
• W2591470147 creator A5087142746 @default.
• W2591470147 date "2012-02-01" @default.
• W2591470147 modified "2023-10-18" @default.
• W2591470147 title "Is elevated preoperative CEA level a significant predictor for decreased overall survival in patients with stage I to III rectal cancer?" @default.
• W2591470147 doi "https://doi.org/10.1200/jco.2012.30.4_suppl.403" @default.
• W2591470147 hasPublicationYear "2012" @default.
• W2591470147 type Work @default.
• W2591470147 sameAs 2591470147 @default.
• W2591470147 citedByCount "1" @default.
• W2591470147 countsByYear W25914701472017 @default.
• W2591470147 crossrefType "journal-article" @default.
• W2591470147 hasAuthorship W2591470147A5025191345 @default.
• W2591470147 hasAuthorship W2591470147A5028587740 @default.
• W2591470147 hasAuthorship W2591470147A5031240165 @default.
• W2591470147 hasAuthorship W2591470147A5037282032 @default.
• W2591470147 hasAuthorship W2591470147A5041542671 @default.
• W2591470147 hasAuthorship W2591470147A5087142746 @default.
• W2591470147 hasConcept C121608353 @default.
• W2591470147 hasConcept C126322002 @default.
• W2591470147 hasConcept C141071460 @default.
• W2591470147 hasConcept C146357865 @default.
• W2591470147 hasConcept C151730666 @default.
• W2591470147 hasConcept C156957248 @default.
• W2591470147 hasConcept C207103383 @default.
• W2591470147 hasConcept C2780221984 @default.
• W2591470147 hasConcept C44249647 @default.
• W2591470147 hasConcept C50382708 @default.
• W2591470147 hasConcept C526805850 @default.
• W2591470147 hasConcept C71924100 @default.
• W2591470147 hasConcept C86803240 @default.
• W2591470147 hasConcept C90924648 @default.
• W2591470147 hasConceptScore W2591470147C121608353 @default.
• W2591470147 hasConceptScore W2591470147C126322002 @default.
• W2591470147 hasConceptScore W2591470147C141071460 @default.
• W2591470147 hasConceptScore W2591470147C146357865 @default.
• W2591470147 hasConceptScore W2591470147C151730666 @default.
• W2591470147 hasConceptScore W2591470147C156957248 @default.
• W2591470147 hasConceptScore W2591470147C207103383 @default.
• W2591470147 hasConceptScore W2591470147C2780221984 @default.
• W2591470147 hasConceptScore W2591470147C44249647 @default.
• W2591470147 hasConceptScore W2591470147C50382708 @default.
• W2591470147 hasConceptScore W2591470147C526805850 @default.
• W2591470147 hasConceptScore W2591470147C71924100 @default.
• W2591470147 hasConceptScore W2591470147C86803240 @default.
• W2591470147 hasConceptScore W2591470147C90924648 @default.
• W2591470147 hasIssue "4_suppl" @default.
• W2591470147 hasLocation W25914701471 @default.
• W2591470147 hasOpenAccess W2591470147 @default.
• W2591470147 hasPrimaryLocation W25914701471 @default.
• W2591470147 hasRelatedWork W1964399992 @default.
• W2591470147 hasRelatedWork W2065895388 @default.
• W2591470147 hasRelatedWork W2074568790 @default.
• W2591470147 hasRelatedWork W2115595203 @default.
• W2591470147 hasRelatedWork W2321021262 @default.
• W2591470147 hasRelatedWork W2750934333 @default.
• W2591470147 hasRelatedWork W3017329712 @default.
• W2591470147 hasRelatedWork W3038392370 @default.
• W2591470147 hasRelatedWork W3154231528 @default.
• W2591470147 hasRelatedWork W4361900708 @default.
• W2591470147 hasVolume "30" @default.
• W2591470147 isParatext "false" @default.
• W2591470147 isRetracted "false" @default.
• W2591470147 magId "2591470147" @default.
• W2591470147 workType "article" @default.