FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2591497208> ?p ?o ?g. }

• W2591497208 endingPage "117" @default.
• W2591497208 startingPage "102" @default.
• W2591497208 abstract "Activation of casein kinase 2 (CK2) is closely linked to the body disturbance of carbohydrate metabolism and inflammatory reaction. The renal chronic inflammatory reaction in the setting of diabetes is one of the important hallmarks of diabetic renal fibrosis. However, it remains unknown whether CK2 influences the process of diabetic renal fibrosis. The current study is aimed to investigate if CK2α ameliorates renal inflammatory fibrosis in diabetes via NF-κB pathway. To explore potential regulatory mechanism of CK2α, the expression and activity of CK2α, which were studied by plasmid transfection, selective inhibitor, small-interfering RNA (siRNA) and adenovirus infection in vitro or in vivo, were analyzed by means of western blotting (WB), dual luciferase reporter assay and electrophoretic mobility shift assay (EMSA). The following findings were observed: (1) Expression of CK2α was upregulated in kidneys of db/db and KKAy diabetic mice; (2) Inhibition of CK2α kinase activity or knockdown of CK2α protein expression suppressed high glucose-induced expressions of FN and ICAM-1 in glomerular mesangial cells (GMCs); (3) Inhibition of CK2α kinase activity or knockdown of CK2α protein expression not only restrained IκB degradation, but also suppressed HG-induced nuclear accumulation, transcriptional activity and DNA binding activity of NF-κB in GMCs; (4) Treatment of TBB or CK2α RNAi adenovirus infection ameliorated renal fibrosis in diabetic animals; (5) Treatment of TBB or CK2α RNAi adenovirus infection suppressed IκB degradation and NF-κB nuclear accumulation in glomeruli of diabetic animals. This study indicates the essential role of CK2α in regulating the diabetic renal pathological process of inflammatory fibrosis via NF-κB pathway, and inhibition of CK2α may serve as a promising therapeutic strategy for diabetic nephropathy." @default.
• W2591497208 created "2017-03-03" @default.
• W2591497208 creator A5003463259 @default.
• W2591497208 creator A5009067006 @default.
• W2591497208 creator A5011645410 @default.
• W2591497208 creator A5025574483 @default.
• W2591497208 creator A5033547422 @default.
• W2591497208 creator A5036277902 @default.
• W2591497208 creator A5038096051 @default.
• W2591497208 creator A5047424772 @default.
• W2591497208 creator A5079905053 @default.
• W2591497208 date "2017-05-01" @default.
• W2591497208 modified "2023-10-15" @default.
• W2591497208 title "Protein kinase CK2α catalytic subunit ameliorates diabetic renal inflammatory fibrosis via NF-κB signaling pathway" @default.
• W2591497208 cites W1699506403 @default.
• W2591497208 cites W1968209863 @default.
• W2591497208 cites W1975538737 @default.
• W2591497208 cites W1975788169 @default.
• W2591497208 cites W1976217935 @default.
• W2591497208 cites W1976439710 @default.
• W2591497208 cites W1981367752 @default.
• W2591497208 cites W1996278628 @default.
• W2591497208 cites W1996569414 @default.
• W2591497208 cites W1996854381 @default.
• W2591497208 cites W1997676435 @default.
• W2591497208 cites W2000500184 @default.
• W2591497208 cites W2009141757 @default.
• W2591497208 cites W2010818019 @default.
• W2591497208 cites W2016026930 @default.
• W2591497208 cites W2016778220 @default.
• W2591497208 cites W2020158668 @default.
• W2591497208 cites W2029523063 @default.
• W2591497208 cites W2035886516 @default.
• W2591497208 cites W2036088171 @default.
• W2591497208 cites W2036090583 @default.
• W2591497208 cites W2045188253 @default.
• W2591497208 cites W2045971486 @default.
• W2591497208 cites W2054312934 @default.
• W2591497208 cites W2064621895 @default.
• W2591497208 cites W2068407084 @default.
• W2591497208 cites W2076422310 @default.
• W2591497208 cites W2082948150 @default.
• W2591497208 cites W2108192985 @default.
• W2591497208 cites W2111109876 @default.
• W2591497208 cites W2116263238 @default.
• W2591497208 cites W2119466402 @default.
• W2591497208 cites W2127065370 @default.
• W2591497208 cites W2132732528 @default.
• W2591497208 cites W2142098891 @default.
• W2591497208 cites W2146280915 @default.
• W2591497208 cites W2157942810 @default.
• W2591497208 cites W2177609936 @default.
• W2591497208 cites W2311242079 @default.
• W2591497208 cites W2475210924 @default.
• W2591497208 cites W2492843773 @default.
• W2591497208 cites W2556827888 @default.
• W2591497208 cites W2615684303 @default.
• W2591497208 cites W4365787052 @default.
• W2591497208 doi "https://doi.org/10.1016/j.bcp.2017.02.016" @default.
• W2591497208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28237649" @default.
• W2591497208 hasPublicationYear "2017" @default.
• W2591497208 type Work @default.
• W2591497208 sameAs 2591497208 @default.
• W2591497208 citedByCount "27" @default.
• W2591497208 countsByYear W25914972082017 @default.
• W2591497208 countsByYear W25914972082018 @default.
• W2591497208 countsByYear W25914972082019 @default.
• W2591497208 countsByYear W25914972082020 @default.
• W2591497208 countsByYear W25914972082021 @default.
• W2591497208 countsByYear W25914972082022 @default.
• W2591497208 crossrefType "journal-article" @default.
• W2591497208 hasAuthorship W2591497208A5003463259 @default.
• W2591497208 hasAuthorship W2591497208A5009067006 @default.
• W2591497208 hasAuthorship W2591497208A5011645410 @default.
• W2591497208 hasAuthorship W2591497208A5025574483 @default.
• W2591497208 hasAuthorship W2591497208A5033547422 @default.
• W2591497208 hasAuthorship W2591497208A5036277902 @default.
• W2591497208 hasAuthorship W2591497208A5038096051 @default.
• W2591497208 hasAuthorship W2591497208A5047424772 @default.
• W2591497208 hasAuthorship W2591497208A5079905053 @default.
• W2591497208 hasConcept C100175707 @default.
• W2591497208 hasConcept C104317684 @default.
• W2591497208 hasConcept C126322002 @default.
• W2591497208 hasConcept C127561419 @default.
• W2591497208 hasConcept C134018914 @default.
• W2591497208 hasConcept C143910341 @default.
• W2591497208 hasConcept C150194340 @default.
• W2591497208 hasConcept C153911025 @default.
• W2591497208 hasConcept C166703698 @default.
• W2591497208 hasConcept C173396325 @default.
• W2591497208 hasConcept C183978625 @default.
• W2591497208 hasConcept C184235292 @default.
• W2591497208 hasConcept C185592680 @default.
• W2591497208 hasConcept C190283241 @default.
• W2591497208 hasConcept C22615655 @default.
• W2591497208 hasConcept C2777730290 @default.
• W2591497208 hasConcept C2779730028 @default.
• W2591497208 hasConcept C2780091579 @default.

• next