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- W2591534446 abstract "Sporothrix schenckii sensu lato causes the subcutaneous mycosis sporotrichosis.1,2 The disease, which is characterised by cutaneous eruptions that spread via the lymphatics, occurs worldwide including Australia.3 Sporothrix schenckii exists as a species complex of at least 6 species4 and it is accepted that Sporothrix varies genetically between different parts of the world.5 We subjected 22 clinical isolates to whole genome sequencing (Ilumina, San Diego, USA). Six isolates were from Western Australia, 11 from New South Wales, 2 from Northern Territory and 3 from Queensland. The molecular phylogeny was inferred by an analysis of 6 genes commonly used in fungal molecular phylogeny – calmodulin, beta-tubulin, chitin synthase, ITS1, terminal elongation factor 1 and 3.5,6 A maximum likelihood tree was constructed using the Hasegawa-Kishino-Yano substitution model with a discrete Gamma distribution and tested with 1000 bootstrap replications using MEGA7.7 Branches defining the discrete taxonomic groups were supported with bootstrap values of 99% or greater. Our results reveal that Western Australian (n=6) and the Northern Territory (n=2) isolates align most closely to Sporothrix schenckii sensu stricto but in two distinct groups. New South Wales (NSW) isolates cluster into a S. schenckii sensu stricto group (n=4) and a S. globosa group n = 6. We also identified one S. pallida from NSW. Queensland isolates align most closely with S. schenckii sensu stricto but in a separate group to the other states. Using whole genome sequencing, we have demonstrated the phylogenetic relationships of Australian isolates within the S. schenckii complex providing genomic data for future comparative work." @default.
- W2591534446 created "2017-03-03" @default.
- W2591534446 creator A5084669368 @default.
- W2591534446 date "2017-02-01" @default.
- W2591534446 modified "2023-09-25" @default.
- W2591534446 title "Whole genome sequencing of Australian isolates of Sporothrix schenckii sensu lato" @default.
- W2591534446 doi "https://doi.org/10.1016/j.pathol.2016.12.117" @default.
- W2591534446 hasPublicationYear "2017" @default.
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