FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2591537677> ?p ?o ?g. }

• W2591537677 endingPage "e14159" @default.
• W2591537677 startingPage "e14159" @default.
• W2591537677 abstract "e14159 Background: Improvement in the treatment of colorectal liver metastases (CLM) demands histopathological indicators of chemotherapy response and predictors of clinical outcome. Currently, decisive factors are the percentage of viable tumor cells and chemotherapy-related tissue changes like tumor necrosis and fibrosis. The goal of this study was to compare the tumor regression grade (TRG) scheme with a newer method, which focuses on the tumor thickness at the tumor-normal-interface (TNI). Methods: A retrospective analysis was performed in 79 patients who underwent neoadjuvant chemotherapy for 3 months (fluoropyrimidine, oxaliplatin and bevacizumab), followed by resection. Both, the TRG modified by Rubbia-Brandt and the TNI by Maru were assessed according to the described protocols. Spearman correlation analyses were performed to identify comparability. The 5 TRG scores were subsumed in major (MjHR), partial (PHR) and no histological response (NHR). Using the method suggested by Maru, the response rates were classified as complete (0% tumor cells), major (<50%) and minor response (≥50%). The mean TNI was categorized in groups of <0,5, 0,5-4,9 and ≥5 mm and correlated to recurrence-free survival (RFS) and overall survival (OS). Results: TRG: 36 (46%) patients showed a MjHR, 19 (24%) a PHR and 24 (30%) patients NHR. According to Maru, eight (10%) patients had a complete response, 52 (66%) a major and 19 (24%) a minor response; TNI: a mean TNI of 0.73 mm (range, 0-2 mm) in major responders and a mean TNI of 1,83 mm (range, 0.5-3.75 mm) in minor responders. Comparison of both methods displayed similar results with significant correlation (Spearman correlation coefficient, r=0,67, P<0,001). Patients with NHR or PHR had a higher risk of relapse (2-year RFS 28%) than patients with MjHR (2-year RFS 41%). The same applies to overall survival (NHR 70% vs. MjHR 89%). Increasing TNI (≥0.5 mm) was associated with a shorter RFS (2-year RFS 29% vs. 43%) and a poorer overall outcome (3-year OS 77% vs. 96%). Conclusions: TRG and tumor thickness at the TNI are equivalent and comparable methods for assessing the degree of pathologic response in CLM, which therefore provide important prognostic information after neoadjuvant therapy." @default.
• W2591537677 created "2017-03-03" @default.
• W2591537677 creator A5006620742 @default.
• W2591537677 creator A5036309711 @default.
• W2591537677 creator A5050306856 @default.
• W2591537677 creator A5051551731 @default.
• W2591537677 creator A5082165203 @default.
• W2591537677 date "2011-05-20" @default.
• W2591537677 modified "2023-09-27" @default.
• W2591537677 title "Pathologic indicators of chemotherapy response in colorectal liver metastases: A comparative study." @default.
• W2591537677 doi "https://doi.org/10.1200/jco.2011.29.15_suppl.e14159" @default.
• W2591537677 hasPublicationYear "2011" @default.
• W2591537677 type Work @default.
• W2591537677 sameAs 2591537677 @default.
• W2591537677 citedByCount "0" @default.
• W2591537677 crossrefType "journal-article" @default.
• W2591537677 hasAuthorship W2591537677A5006620742 @default.
• W2591537677 hasAuthorship W2591537677A5036309711 @default.
• W2591537677 hasAuthorship W2591537677A5050306856 @default.
• W2591537677 hasAuthorship W2591537677A5051551731 @default.
• W2591537677 hasAuthorship W2591537677A5082165203 @default.
• W2591537677 hasConcept C121608353 @default.
• W2591537677 hasConcept C126322002 @default.
• W2591537677 hasConcept C143998085 @default.
• W2591537677 hasConcept C2776694085 @default.
• W2591537677 hasConcept C2777802072 @default.
• W2591537677 hasConcept C2778822529 @default.
• W2591537677 hasConcept C2779984678 @default.
• W2591537677 hasConcept C2780962732 @default.
• W2591537677 hasConcept C526805850 @default.
• W2591537677 hasConcept C71924100 @default.
• W2591537677 hasConcept C90924648 @default.
• W2591537677 hasConceptScore W2591537677C121608353 @default.
• W2591537677 hasConceptScore W2591537677C126322002 @default.
• W2591537677 hasConceptScore W2591537677C143998085 @default.
• W2591537677 hasConceptScore W2591537677C2776694085 @default.
• W2591537677 hasConceptScore W2591537677C2777802072 @default.
• W2591537677 hasConceptScore W2591537677C2778822529 @default.
• W2591537677 hasConceptScore W2591537677C2779984678 @default.
• W2591537677 hasConceptScore W2591537677C2780962732 @default.
• W2591537677 hasConceptScore W2591537677C526805850 @default.
• W2591537677 hasConceptScore W2591537677C71924100 @default.
• W2591537677 hasConceptScore W2591537677C90924648 @default.
• W2591537677 hasIssue "15_suppl" @default.
• W2591537677 hasLocation W25915376771 @default.
• W2591537677 hasOpenAccess W2591537677 @default.
• W2591537677 hasPrimaryLocation W25915376771 @default.
• W2591537677 hasRelatedWork W1997133872 @default.
• W2591537677 hasRelatedWork W2050348440 @default.
• W2591537677 hasRelatedWork W2051540233 @default.
• W2591537677 hasRelatedWork W2098707609 @default.
• W2591537677 hasRelatedWork W2145753255 @default.
• W2591537677 hasRelatedWork W2316610093 @default.
• W2591537677 hasRelatedWork W2340695374 @default.
• W2591537677 hasRelatedWork W2465617904 @default.
• W2591537677 hasRelatedWork W2545945608 @default.
• W2591537677 hasRelatedWork W1967062665 @default.
• W2591537677 hasVolume "29" @default.
• W2591537677 isParatext "false" @default.
• W2591537677 isRetracted "false" @default.
• W2591537677 magId "2591537677" @default.
• W2591537677 workType "article" @default.