FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2591563151> ?p ?o ?g. }

• W2591563151 endingPage "32768" @default.
• W2591563151 startingPage "32752" @default.
• W2591563151 abstract "We previously demonstrated that chemopreventive methylselenocysteine (MSC) prevents N-Nitroso-N-methylurea (NMU)-induced mammary carcinogenesis in the susceptible Fischer 344 (F344) rats by enhancing NAD+-dependent SIRT1 activity, restoring circadian expression of Period 2 (Per2) and circadian controlled genes. Here, we show that compared to the genetically resistant Copenhagen (COP) rat strain, mammary glands of the F344 rats have a 4-hour phase delay in circadian expression of Per2. Consequently, F344 rats failed to increase SIRT1 activity and circadian expression of Per2 and DDRR genes after exposure to NMU. Exposure of COP rats to NMU had the opposite effect, enhancing SIRT1 activity, increasing circadian expression of Per2 and DDRR genes. Significantly, SIRT1 activity and circadian expression of Per2 and DDRR genes in NMU-treated F344 rats on a chemopreventive regimen of MSC approximated those in NMU-treated COP rats. These results indicated that COP rats have an increased capacity to maintain NAD+-dependent SIRT1 activity under genotoxic stress. This contention was supported by increased stability of the period and phase of circadian locomotor activity in COP vs F344 rats exposed to changing light conditions. The increased sensitivity and rapid response of COP to changing light were correlated with the enhanced circadian response of this strain to carcinogen. Disturbance of circadian rhythm by jet lag also disrupted circadian expression of Per2 and DDRR genes, and accelerated mammary tumorigenesis in rodent models. These results suggested that uncoupling of DDRR responses from circadian control by environmental stresses and endogenous factors increases susceptibility to mammary carcinogenesis, possibly by inducing a promutagenic state." @default.
• W2591563151 created "2017-03-03" @default.
• W2591563151 creator A5002310950 @default.
• W2591563151 creator A5055849392 @default.
• W2591563151 creator A5077030178 @default.
• W2591563151 creator A5079986279 @default.
• W2591563151 date "2017-02-24" @default.
• W2591563151 modified "2023-10-03" @default.
• W2591563151 title "Uncoupling genotoxic stress responses from circadian control increases susceptibility to mammary carcinogenesis" @default.
• W2591563151 cites W114098355 @default.
• W2591563151 cites W1490013364 @default.
• W2591563151 cites W1557668836 @default.
• W2591563151 cites W1566896910 @default.
• W2591563151 cites W1607785571 @default.
• W2591563151 cites W1742308847 @default.
• W2591563151 cites W1910049912 @default.
• W2591563151 cites W192129758 @default.
• W2591563151 cites W1963970141 @default.
• W2591563151 cites W1964544156 @default.
• W2591563151 cites W1965692940 @default.
• W2591563151 cites W1968890500 @default.
• W2591563151 cites W1973099196 @default.
• W2591563151 cites W1974759039 @default.
• W2591563151 cites W1976081689 @default.
• W2591563151 cites W1982320089 @default.
• W2591563151 cites W1984459329 @default.
• W2591563151 cites W1985292789 @default.
• W2591563151 cites W1986985221 @default.
• W2591563151 cites W1990903366 @default.
• W2591563151 cites W1992913613 @default.
• W2591563151 cites W1994994441 @default.
• W2591563151 cites W1997364930 @default.
• W2591563151 cites W2006004036 @default.
• W2591563151 cites W2009714890 @default.
• W2591563151 cites W2013045119 @default.
• W2591563151 cites W2015398239 @default.
• W2591563151 cites W2025740950 @default.
• W2591563151 cites W2030755971 @default.
• W2591563151 cites W2034278983 @default.
• W2591563151 cites W2036150473 @default.
• W2591563151 cites W2040629892 @default.
• W2591563151 cites W2052621025 @default.
• W2591563151 cites W2053243600 @default.
• W2591563151 cites W2053878253 @default.
• W2591563151 cites W2054190001 @default.
• W2591563151 cites W2056977280 @default.
• W2591563151 cites W2063041018 @default.
• W2591563151 cites W2067670440 @default.
• W2591563151 cites W2075873641 @default.
• W2591563151 cites W2076061256 @default.
• W2591563151 cites W2077038726 @default.
• W2591563151 cites W2081882184 @default.
• W2591563151 cites W2085223541 @default.
• W2591563151 cites W2095697394 @default.
• W2591563151 cites W2102914417 @default.
• W2591563151 cites W2103150975 @default.
• W2591563151 cites W2104058747 @default.
• W2591563151 cites W2109091275 @default.
• W2591563151 cites W2120127195 @default.
• W2591563151 cites W2120479056 @default.
• W2591563151 cites W2121574536 @default.
• W2591563151 cites W2124276356 @default.
• W2591563151 cites W2124512064 @default.
• W2591563151 cites W2126618928 @default.
• W2591563151 cites W2128032039 @default.
• W2591563151 cites W2130431253 @default.
• W2591563151 cites W2137949150 @default.
• W2591563151 cites W2139672495 @default.
• W2591563151 cites W2141055911 @default.
• W2591563151 cites W2141521138 @default.
• W2591563151 cites W2146556472 @default.
• W2591563151 cites W2150081842 @default.
• W2591563151 cites W2157613001 @default.
• W2591563151 cites W2161162458 @default.
• W2591563151 cites W2161548459 @default.
• W2591563151 cites W2162469302 @default.
• W2591563151 cites W2163183531 @default.
• W2591563151 cites W2171355669 @default.
• W2591563151 cites W2177592974 @default.
• W2591563151 cites W2181752043 @default.
• W2591563151 cites W2261224185 @default.
• W2591563151 cites W434402811 @default.
• W2591563151 cites W2419533637 @default.
• W2591563151 doi "https://doi.org/10.18632/oncotarget.15678" @default.
• W2591563151 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5464825" @default.
• W2591563151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28427145" @default.
• W2591563151 hasPublicationYear "2017" @default.
• W2591563151 type Work @default.
• W2591563151 sameAs 2591563151 @default.
• W2591563151 citedByCount "13" @default.
• W2591563151 countsByYear W25915631512017 @default.
• W2591563151 countsByYear W25915631512018 @default.
• W2591563151 countsByYear W25915631512019 @default.
• W2591563151 countsByYear W25915631512020 @default.
• W2591563151 countsByYear W25915631512021 @default.
• W2591563151 countsByYear W25915631512022 @default.
• W2591563151 countsByYear W25915631512023 @default.
• W2591563151 crossrefType "journal-article" @default.

• next