Matches in SemOpenAlex for { <https://semopenalex.org/work/W2591580045> ?p ?o ?g. }
- W2591580045 abstract "Wallerian degeneration (WD) in injured peripheral nerves is associated with a large number of up- or down-regulated genes, but the effects of these changes are poorly understood. In our previous studies, we reported some key factors that are differentially expressed to activate nerve degeneration and regeneration during WD. Here, we determined the effects of secreted phosphoprotein 1 (Spp1) on WD after rat sciatic nerve injury. Spp1 was upregulated from 6 h to 14 days after sciatic nerve injury. Altered expression of Spp1 in Schwann cells (SC) resulted in altered mRNA and protein expression levels for cytokines, c-Fos, PKCα and phospho-ERK/ERK and affected SC apoptosis in vitro. Silencing of Spp1 expression in SCs using siRNA technology reduced proliferation and promoted migration of SCs in vitro. By contrast, overexpression of Spp1 promoted proliferation and reduced migration in SCs in vitro. Differential expression of Spp1 after sciatic nerve injury in vivo altered the expression of cytokines, c-Fos, PKCα, and the p-ERK/ERK pathway. Spp1 is a key regulatory factor that affects nerve degeneration and regeneration through c-Fos, PKCα and p-ERK/ERK pathways after rat sciatic nerve injury. These results shed new light on the role of Spp1 in nerve degeneration and regeneration during WD." @default.
- W2591580045 created "2017-03-16" @default.
- W2591580045 creator A5012958259 @default.
- W2591580045 creator A5035139835 @default.
- W2591580045 creator A5035989013 @default.
- W2591580045 creator A5037192036 @default.
- W2591580045 creator A5039860525 @default.
- W2591580045 creator A5041505370 @default.
- W2591580045 creator A5073888877 @default.
- W2591580045 creator A5088480448 @default.
- W2591580045 date "2017-03-07" @default.
- W2591580045 modified "2023-10-03" @default.
- W2591580045 title "Effect of Spp1 on nerve degeneration and regeneration after rat sciatic nerve injury" @default.
- W2591580045 cites W1504916988 @default.
- W2591580045 cites W1506359711 @default.
- W2591580045 cites W1519321821 @default.
- W2591580045 cites W1784352764 @default.
- W2591580045 cites W1828557676 @default.
- W2591580045 cites W1909855426 @default.
- W2591580045 cites W1965571714 @default.
- W2591580045 cites W1968547119 @default.
- W2591580045 cites W1969711591 @default.
- W2591580045 cites W1970902340 @default.
- W2591580045 cites W1971796589 @default.
- W2591580045 cites W1976138487 @default.
- W2591580045 cites W1976726488 @default.
- W2591580045 cites W1978494928 @default.
- W2591580045 cites W1992900501 @default.
- W2591580045 cites W2002397995 @default.
- W2591580045 cites W2013353248 @default.
- W2591580045 cites W2019919875 @default.
- W2591580045 cites W2030958472 @default.
- W2591580045 cites W2041891376 @default.
- W2591580045 cites W2047062738 @default.
- W2591580045 cites W2056859189 @default.
- W2591580045 cites W2057855349 @default.
- W2591580045 cites W2059322280 @default.
- W2591580045 cites W2062483863 @default.
- W2591580045 cites W2063676693 @default.
- W2591580045 cites W2077580553 @default.
- W2591580045 cites W2098032045 @default.
- W2591580045 cites W2104512225 @default.
- W2591580045 cites W2116356198 @default.
- W2591580045 cites W2122471147 @default.
- W2591580045 cites W2129442835 @default.
- W2591580045 cites W2132419184 @default.
- W2591580045 cites W2136869658 @default.
- W2591580045 cites W2142121745 @default.
- W2591580045 cites W2142790782 @default.
- W2591580045 cites W2144185062 @default.
- W2591580045 cites W2152781778 @default.
- W2591580045 cites W2156043911 @default.
- W2591580045 cites W2165804706 @default.
- W2591580045 cites W2231313877 @default.
- W2591580045 cites W2339391327 @default.
- W2591580045 cites W288202409 @default.
- W2591580045 cites W4297914865 @default.
- W2591580045 doi "https://doi.org/10.1186/s12868-017-0348-1" @default.
- W2591580045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5341472" @default.
- W2591580045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28270094" @default.
- W2591580045 hasPublicationYear "2017" @default.
- W2591580045 type Work @default.
- W2591580045 sameAs 2591580045 @default.
- W2591580045 citedByCount "17" @default.
- W2591580045 countsByYear W25915800452018 @default.
- W2591580045 countsByYear W25915800452019 @default.
- W2591580045 countsByYear W25915800452020 @default.
- W2591580045 countsByYear W25915800452021 @default.
- W2591580045 countsByYear W25915800452022 @default.
- W2591580045 countsByYear W25915800452023 @default.
- W2591580045 crossrefType "journal-article" @default.
- W2591580045 hasAuthorship W2591580045A5012958259 @default.
- W2591580045 hasAuthorship W2591580045A5035139835 @default.
- W2591580045 hasAuthorship W2591580045A5035989013 @default.
- W2591580045 hasAuthorship W2591580045A5037192036 @default.
- W2591580045 hasAuthorship W2591580045A5039860525 @default.
- W2591580045 hasAuthorship W2591580045A5041505370 @default.
- W2591580045 hasAuthorship W2591580045A5073888877 @default.
- W2591580045 hasAuthorship W2591580045A5088480448 @default.
- W2591580045 hasBestOaLocation W25915800451 @default.
- W2591580045 hasConcept C104317684 @default.
- W2591580045 hasConcept C105702510 @default.
- W2591580045 hasConcept C119056186 @default.
- W2591580045 hasConcept C169760540 @default.
- W2591580045 hasConcept C171056886 @default.
- W2591580045 hasConcept C2775991916 @default.
- W2591580045 hasConcept C2776588550 @default.
- W2591580045 hasConcept C2776880756 @default.
- W2591580045 hasConcept C2779683492 @default.
- W2591580045 hasConcept C2780862704 @default.
- W2591580045 hasConcept C2781149210 @default.
- W2591580045 hasConcept C55493867 @default.
- W2591580045 hasConcept C57074206 @default.
- W2591580045 hasConcept C62478195 @default.
- W2591580045 hasConcept C71924100 @default.
- W2591580045 hasConcept C86803240 @default.
- W2591580045 hasConcept C95444343 @default.
- W2591580045 hasConceptScore W2591580045C104317684 @default.
- W2591580045 hasConceptScore W2591580045C105702510 @default.
- W2591580045 hasConceptScore W2591580045C119056186 @default.