Matches in SemOpenAlex for { <https://semopenalex.org/work/W2591634122> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2591634122 endingPage "198" @default.
- W2591634122 startingPage "193" @default.
- W2591634122 abstract "Anemia is a common problem in rheumatoid arthritis (RA), associated with radiographic progression and disability. We explored the association of hemoglobin with a comprehensive set of variables in RA patients. We included RA outpatients in the routine setting. For each patient we performed measurements (clinical measures, blood tests including serology, markers of acute phase response and iron metabolism, including hepcidin, and circulating hematopoietic precursor levels) at baseline and 12 weeks thereafter, and analyzed their changes in patients with a treatment adaptation at baseline. We performed principal component analysis (PCA) to identify thematic groups hemoglobin was related to. Then we constructed multivariable linear models to assess the contribution of individual variables to the variability of hemoglobin. In total, 88 patients were included (age: 58 ± 12; disease duration: 9.3 ± 9.6 years). Cross-sectionally (at baseline and week 12) hemoglobin levels were tied to iron metabolism and hematopoiesis, but not to clinical activity, based on thematic groups extracted from the PCA. In contrast, longitudinal changes in hemoglobin levels were closely linked to changes in clinical activity. Conversely, hepcidin reflected iron metabolism cross-sectionally, but changes in acute phase response longitudinally. In multivariable analysis variability components of hemoglobin were explainable by ferritin, ESR, evaluator global assessment (EGA), and iron levels, while components of hemoglobin changes were explained by changes in EGA mostly. Hepcidin was not independently associated with hemoglobin. Besides its dependence on body iron status, changes in hemoglobin levels are strongly tied to disease activity, possibly revealing more about disease activity than other laboratory markers." @default.
- W2591634122 created "2017-03-16" @default.
- W2591634122 creator A5016536275 @default.
- W2591634122 creator A5021553003 @default.
- W2591634122 creator A5034322412 @default.
- W2591634122 creator A5061411814 @default.
- W2591634122 creator A5071494532 @default.
- W2591634122 creator A5090753435 @default.
- W2591634122 date "2017-10-01" @default.
- W2591634122 modified "2023-10-11" @default.
- W2591634122 title "Clinical meaning and implications of serum hemoglobin levels in patients with rheumatoid arthritis" @default.
- W2591634122 cites W1863522597 @default.
- W2591634122 cites W1991683151 @default.
- W2591634122 cites W2008133378 @default.
- W2591634122 cites W2019251546 @default.
- W2591634122 cites W2055138591 @default.
- W2591634122 cites W2075497845 @default.
- W2591634122 cites W2077573212 @default.
- W2591634122 cites W2090821093 @default.
- W2591634122 cites W2104482697 @default.
- W2591634122 cites W2114448779 @default.
- W2591634122 cites W2123200029 @default.
- W2591634122 cites W2123576922 @default.
- W2591634122 cites W2128952811 @default.
- W2591634122 cites W2131026218 @default.
- W2591634122 cites W2134536226 @default.
- W2591634122 cites W2136074635 @default.
- W2591634122 cites W2143660712 @default.
- W2591634122 cites W2144762512 @default.
- W2591634122 cites W2163230336 @default.
- W2591634122 cites W2163447382 @default.
- W2591634122 cites W2166499143 @default.
- W2591634122 cites W4210968471 @default.
- W2591634122 cites W4249150518 @default.
- W2591634122 doi "https://doi.org/10.1016/j.semarthrit.2017.03.001" @default.
- W2591634122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28385457" @default.
- W2591634122 hasPublicationYear "2017" @default.
- W2591634122 type Work @default.
- W2591634122 sameAs 2591634122 @default.
- W2591634122 citedByCount "13" @default.
- W2591634122 countsByYear W25916341222019 @default.
- W2591634122 countsByYear W25916341222020 @default.
- W2591634122 countsByYear W25916341222021 @default.
- W2591634122 countsByYear W25916341222022 @default.
- W2591634122 countsByYear W25916341222023 @default.
- W2591634122 crossrefType "journal-article" @default.
- W2591634122 hasAuthorship W2591634122A5016536275 @default.
- W2591634122 hasAuthorship W2591634122A5021553003 @default.
- W2591634122 hasAuthorship W2591634122A5034322412 @default.
- W2591634122 hasAuthorship W2591634122A5061411814 @default.
- W2591634122 hasAuthorship W2591634122A5071494532 @default.
- W2591634122 hasAuthorship W2591634122A5090753435 @default.
- W2591634122 hasConcept C126322002 @default.
- W2591634122 hasConcept C203014093 @default.
- W2591634122 hasConcept C2776768029 @default.
- W2591634122 hasConcept C2777575956 @default.
- W2591634122 hasConcept C2778248108 @default.
- W2591634122 hasConcept C2778319317 @default.
- W2591634122 hasConcept C2778917026 @default.
- W2591634122 hasConcept C71924100 @default.
- W2591634122 hasConcept C90924648 @default.
- W2591634122 hasConceptScore W2591634122C126322002 @default.
- W2591634122 hasConceptScore W2591634122C203014093 @default.
- W2591634122 hasConceptScore W2591634122C2776768029 @default.
- W2591634122 hasConceptScore W2591634122C2777575956 @default.
- W2591634122 hasConceptScore W2591634122C2778248108 @default.
- W2591634122 hasConceptScore W2591634122C2778319317 @default.
- W2591634122 hasConceptScore W2591634122C2778917026 @default.
- W2591634122 hasConceptScore W2591634122C71924100 @default.
- W2591634122 hasConceptScore W2591634122C90924648 @default.
- W2591634122 hasIssue "2" @default.
- W2591634122 hasLocation W25916341221 @default.
- W2591634122 hasLocation W25916341222 @default.
- W2591634122 hasOpenAccess W2591634122 @default.
- W2591634122 hasPrimaryLocation W25916341221 @default.
- W2591634122 hasRelatedWork W123990863 @default.
- W2591634122 hasRelatedWork W1532551612 @default.
- W2591634122 hasRelatedWork W1892447132 @default.
- W2591634122 hasRelatedWork W1993789439 @default.
- W2591634122 hasRelatedWork W2001670904 @default.
- W2591634122 hasRelatedWork W2064624641 @default.
- W2591634122 hasRelatedWork W2119692723 @default.
- W2591634122 hasRelatedWork W2159753241 @default.
- W2591634122 hasRelatedWork W2925132551 @default.
- W2591634122 hasRelatedWork W3152300257 @default.
- W2591634122 hasVolume "47" @default.
- W2591634122 isParatext "false" @default.
- W2591634122 isRetracted "false" @default.
- W2591634122 magId "2591634122" @default.
- W2591634122 workType "article" @default.