FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2591652092> ?p ?o ?g. }

• W2591652092 endingPage "390" @default.
• W2591652092 startingPage "363" @default.
• W2591652092 abstract "Cells, both eukaryotic and prokaryotic, are covered with complex and diverse glycoconjugates that dictate interactions with the environment. In addition, intracellular glycoconjugates play key roles in intracellular signaling. Methods to selectively label, image, and purify glycoconjugates are critical to understanding their biological functions. The challenge of specifically tagging glycoconjugates is compounded by the fact that these biopolymers are not primary gene products, and therefore not amenable to genetic tagging. Thus, methods to chemoselectively address specific glycoconjugates are essential tools for studying glycoconjugate localization and behavior. This chapter begins with a brief introduction to the diversity of eukaryotic glycosylation. This is followed by discussion of chemoselective and chemoenzymatic labeling reactions that take advantage of the endogenous reactivity of native carbohydrate structures to achieve selective labeling of specific glycoconjugate classes. Next, we describe the use of metabolic oligosaccharide engineering using unnatural sugar precursors to introduce non-native functionalities that can be used for chemoselective labeling reactions, thereby achieving selective labeling of eukaryotic glycoconjugates. We also discuss how mutually orthogonal bioorthogonal reactions can be used in a combinatorial fashion to label distinct glycoconjugates. While the majority of the chapter focuses on eukaryotic glycoconjugates, the final section highlights examples of the application of chemoselective labeling reactions to bacterial glycoconjugates, an exciting emerging area of research. These examples demonstrate that chemoselective labeling reactions are an enabling technology that is facilitating multiple aspects of glycoscience research." @default.
• W2591652092 created "2017-03-16" @default.
• W2591652092 creator A5025113653 @default.
• W2591652092 creator A5080867247 @default.
• W2591652092 date "2017-03-03" @default.
• W2591652092 modified "2023-10-17" @default.
• W2591652092 title "Chemoselective Reactions for Glycan Labeling" @default.
• W2591652092 cites W1561390296 @default.
• W2591652092 cites W1972074273 @default.
• W2591652092 cites W1981659539 @default.
• W2591652092 cites W1984798681 @default.
• W2591652092 cites W1986261235 @default.
• W2591652092 cites W1987347411 @default.
• W2591652092 cites W1987966136 @default.
• W2591652092 cites W1988901523 @default.
• W2591652092 cites W1992034958 @default.
• W2591652092 cites W1995839837 @default.
• W2591652092 cites W1996786134 @default.
• W2591652092 cites W1997099073 @default.
• W2591652092 cites W1999902909 @default.
• W2591652092 cites W2002916661 @default.
• W2591652092 cites W2003668338 @default.
• W2591652092 cites W2006296741 @default.
• W2591652092 cites W2007414195 @default.
• W2591652092 cites W2015232449 @default.
• W2591652092 cites W2024551447 @default.
• W2591652092 cites W2025562232 @default.
• W2591652092 cites W2027170262 @default.
• W2591652092 cites W2029489645 @default.
• W2591652092 cites W2030555571 @default.
• W2591652092 cites W2033877739 @default.
• W2591652092 cites W2034156062 @default.
• W2591652092 cites W2034809848 @default.
• W2591652092 cites W2041465346 @default.
• W2591652092 cites W2043070664 @default.
• W2591652092 cites W2043528950 @default.
• W2591652092 cites W2050288185 @default.
• W2591652092 cites W2050554863 @default.
• W2591652092 cites W2056858168 @default.
• W2591652092 cites W2057153919 @default.
• W2591652092 cites W2059099393 @default.
• W2591652092 cites W2059725389 @default.
• W2591652092 cites W2060270009 @default.
• W2591652092 cites W2062088650 @default.
• W2591652092 cites W2063432830 @default.
• W2591652092 cites W2063543014 @default.
• W2591652092 cites W2065609269 @default.
• W2591652092 cites W2065829276 @default.
• W2591652092 cites W2066580507 @default.
• W2591652092 cites W2068602210 @default.
• W2591652092 cites W2074443029 @default.
• W2591652092 cites W2074868161 @default.
• W2591652092 cites W2077093780 @default.
• W2591652092 cites W2077455300 @default.
• W2591652092 cites W2077790287 @default.
• W2591652092 cites W2079324365 @default.
• W2591652092 cites W2082075183 @default.
• W2591652092 cites W2083260383 @default.
• W2591652092 cites W2083510841 @default.
• W2591652092 cites W2086570977 @default.
• W2591652092 cites W2097670917 @default.
• W2591652092 cites W2098120385 @default.
• W2591652092 cites W2099402486 @default.
• W2591652092 cites W2100700853 @default.
• W2591652092 cites W2103853642 @default.
• W2591652092 cites W2106523172 @default.
• W2591652092 cites W2108631262 @default.
• W2591652092 cites W2117946498 @default.
• W2591652092 cites W2118002029 @default.
• W2591652092 cites W2118633640 @default.
• W2591652092 cites W2122381557 @default.
• W2591652092 cites W2133333622 @default.
• W2591652092 cites W2137741805 @default.
• W2591652092 cites W2149202312 @default.
• W2591652092 cites W2155755315 @default.
• W2591652092 cites W2158381930 @default.
• W2591652092 cites W2158502376 @default.
• W2591652092 cites W2162896436 @default.
• W2591652092 cites W2163597141 @default.
• W2591652092 cites W2322691084 @default.
• W2591652092 cites W4211031782 @default.
• W2591652092 cites W4248522153 @default.
• W2591652092 doi "https://doi.org/10.1002/9783527683451.ch12" @default.
• W2591652092 hasPublicationYear "2017" @default.
• W2591652092 type Work @default.
• W2591652092 sameAs 2591652092 @default.
• W2591652092 citedByCount "0" @default.
• W2591652092 crossrefType "other" @default.
• W2591652092 hasAuthorship W2591652092A5025113653 @default.
• W2591652092 hasAuthorship W2591652092A5080867247 @default.
• W2591652092 hasConcept C108625454 @default.
• W2591652092 hasConcept C13426554 @default.
• W2591652092 hasConcept C185592680 @default.
• W2591652092 hasConcept C206212055 @default.
• W2591652092 hasConcept C21951064 @default.
• W2591652092 hasConcept C2777313579 @default.
• W2591652092 hasConcept C55493867 @default.
• W2591652092 hasConcept C69610077 @default.

• next