FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2591691881> ?p ?o ?g. }

• W2591691881 endingPage "20162743" @default.
• W2591691881 startingPage "20162743" @default.
• W2591691881 abstract "Like many aquatic vertebrates, whales have blue-shifting spectral tuning substitutions in the dim-light visual pigment, rhodopsin, that are thought to increase photosensitivity in underwater environments. We have discovered that known spectral tuning substitutions also have surprising epistatic effects on another function of rhodopsin, the kinetic rates associated with light-activated intermediates. By using absorbance spectroscopy and fluorescence-based retinal release assays on heterologously expressed rhodopsin, we assessed both spectral and kinetic differences between cetaceans (killer whale) and terrestrial outgroups (hippo, bovine). Mutation experiments revealed that killer whale rhodopsin is unusually resilient to pleiotropic effects on retinal release from key blue-shifting substitutions (D83N and A292S), largely due to a surprisingly specific epistatic interaction between D83N and the background residue, S299. Ancestral sequence reconstruction indicated that S299 is an ancestral residue that predates the evolution of blue-shifting substitutions at the origins of Cetacea. Based on these results, we hypothesize that intramolecular epistasis helped to conserve rhodopsin's kinetic properties while enabling blue-shifting spectral tuning substitutions as cetaceans adapted to aquatic environments. Trade-offs between different aspects of molecular function are rarely considered in protein evolution, but in cetacean and other vertebrate rhodopsins, may underlie multiple evolutionary scenarios for the selection of specific amino acid substitutions." @default.
• W2591691881 created "2017-03-16" @default.
• W2591691881 creator A5002949528 @default.
• W2591691881 creator A5091045379 @default.
• W2591691881 date "2017-03-01" @default.
• W2591691881 modified "2023-09-26" @default.
• W2591691881 title "Epistatic interactions influence terrestrial–marine functional shifts in cetacean rhodopsin" @default.
• W2591691881 cites W1607931568 @default.
• W2591691881 cites W1774709940 @default.
• W2591691881 cites W1789110127 @default.
• W2591691881 cites W1934360192 @default.
• W2591691881 cites W1958221885 @default.
• W2591691881 cites W1968235860 @default.
• W2591691881 cites W1981605835 @default.
• W2591691881 cites W1983567190 @default.
• W2591691881 cites W1985512910 @default.
• W2591691881 cites W1985935990 @default.
• W2591691881 cites W1986191025 @default.
• W2591691881 cites W1990251856 @default.
• W2591691881 cites W1992192767 @default.
• W2591691881 cites W1994019984 @default.
• W2591691881 cites W1999613945 @default.
• W2591691881 cites W2003758281 @default.
• W2591691881 cites W2016666153 @default.
• W2591691881 cites W2019467929 @default.
• W2591691881 cites W2020697299 @default.
• W2591691881 cites W2027756143 @default.
• W2591691881 cites W2030196928 @default.
• W2591691881 cites W2031984034 @default.
• W2591691881 cites W2044645928 @default.
• W2591691881 cites W2054508286 @default.
• W2591691881 cites W2056094838 @default.
• W2591691881 cites W2059551149 @default.
• W2591691881 cites W2064504949 @default.
• W2591691881 cites W2070487314 @default.
• W2591691881 cites W2071461674 @default.
• W2591691881 cites W2073499572 @default.
• W2591691881 cites W2097365951 @default.
• W2591691881 cites W2109798566 @default.
• W2591691881 cites W2110335151 @default.
• W2591691881 cites W2116682555 @default.
• W2591691881 cites W2116868014 @default.
• W2591691881 cites W2123209028 @default.
• W2591691881 cites W2124756639 @default.
• W2591691881 cites W2128848159 @default.
• W2591691881 cites W2136764532 @default.
• W2591691881 cites W2136831079 @default.
• W2591691881 cites W2141555161 @default.
• W2591691881 cites W2149963584 @default.
• W2591691881 cites W2152207030 @default.
• W2591691881 cites W2157308120 @default.
• W2591691881 cites W2211060246 @default.
• W2591691881 cites W2274840413 @default.
• W2591691881 cites W2294949682 @default.
• W2591691881 cites W2415875693 @default.
• W2591691881 cites W2471654536 @default.
• W2591691881 cites W2473604086 @default.
• W2591691881 doi "https://doi.org/10.1098/rspb.2016.2743" @default.
• W2591691881 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5360924" @default.
• W2591691881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28250185" @default.
• W2591691881 hasPublicationYear "2017" @default.
• W2591691881 type Work @default.
• W2591691881 sameAs 2591691881 @default.
• W2591691881 citedByCount "22" @default.
• W2591691881 countsByYear W25916918812017 @default.
• W2591691881 countsByYear W25916918812018 @default.
• W2591691881 countsByYear W25916918812019 @default.
• W2591691881 countsByYear W25916918812020 @default.
• W2591691881 countsByYear W25916918812021 @default.
• W2591691881 countsByYear W25916918812022 @default.
• W2591691881 countsByYear W25916918812023 @default.
• W2591691881 crossrefType "journal-article" @default.
• W2591691881 hasAuthorship W2591691881A5002949528 @default.
• W2591691881 hasAuthorship W2591691881A5091045379 @default.
• W2591691881 hasBestOaLocation W25916918811 @default.
• W2591691881 hasConcept C104317684 @default.
• W2591691881 hasConcept C166393388 @default.
• W2591691881 hasConcept C202033177 @default.
• W2591691881 hasConcept C2778944004 @default.
• W2591691881 hasConcept C2778961482 @default.
• W2591691881 hasConcept C2780827179 @default.
• W2591691881 hasConcept C30028475 @default.
• W2591691881 hasConcept C54355233 @default.
• W2591691881 hasConcept C55493867 @default.
• W2591691881 hasConcept C61727976 @default.
• W2591691881 hasConcept C78458016 @default.
• W2591691881 hasConcept C86803240 @default.
• W2591691881 hasConcept C90132467 @default.
• W2591691881 hasConceptScore W2591691881C104317684 @default.
• W2591691881 hasConceptScore W2591691881C166393388 @default.
• W2591691881 hasConceptScore W2591691881C202033177 @default.
• W2591691881 hasConceptScore W2591691881C2778944004 @default.
• W2591691881 hasConceptScore W2591691881C2778961482 @default.
• W2591691881 hasConceptScore W2591691881C2780827179 @default.
• W2591691881 hasConceptScore W2591691881C30028475 @default.
• W2591691881 hasConceptScore W2591691881C54355233 @default.
• W2591691881 hasConceptScore W2591691881C55493867 @default.
• W2591691881 hasConceptScore W2591691881C61727976 @default.

• next