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• W2591696989 abstract "<h3>Importance</h3> As men age, they experience decreased serum testosterone concentrations, decreased bone mineral density (BMD), and increased risk of fracture. <h3>Objective</h3> To determine whether testosterone treatment of older men with low testosterone increases volumetric BMD (vBMD) and estimated bone strength. <h3>Design, Setting, and Participants</h3> Placebo-controlled, double-blind trial with treatment allocation by minimization at 9 US academic medical centers of men 65 years or older with 2 testosterone concentrations averaging less than 275 ng/L participating in the Testosterone Trials from December 2011 to June 2014. The analysis was a modified intent-to-treat comparison of treatment groups by multivariable linear regression adjusted for balancing factors as required by minimization. <h3>Interventions</h3> Testosterone gel, adjusted to maintain the testosterone level within the normal range for young men, or placebo gel for 1 year. <h3>Main Outcomes and Measures</h3> Spine and hip vBMD was determined by quantitative computed tomography at baseline and 12 months. Bone strength was estimated by finite element analysis of quantitative computed tomography data. Areal BMD was assessed by dual energy x-ray absorptiometry at baseline and 12 months. <h3>Results</h3> There were 211 participants (mean [SD] age, 72.3 [5.9] years; 86% white; mean [SD] body mass index, 31.2 [3.4]). Testosterone treatment was associated with significantly greater increases than placebo in mean spine trabecular vBMD (7.5%; 95% CI, 4.8% to 10.3% vs 0.8%; 95% CI, −1.9% to 3.4%; treatment effect, 6.8%; 95% CI, 4.8%-8.7%;<i>P</i> < .001), spine peripheral vBMD, hip trabecular and peripheral vBMD, and mean estimated strength of spine trabecular bone (10.8%; 95% CI, 7.4% to 14.3% vs 2.4%; 95% CI, −1.0% to 5.7%; treatment effect, 8.5%; 95% CI, 6.0%-10.9%;<i>P </i>< .001), spine peripheral bone, and hip trabecular and peripheral bone. The estimated strength increases were greater in trabecular than peripheral bone and greater in the spine than hip. Testosterone treatment increased spine areal BMD but less than vBMD. <h3>Conclusions and Relevance</h3> Testosterone treatment for 1 year of older men with low testosterone significantly increased vBMD and estimated bone strength, more in trabecular than peripheral bone and more in the spine than hip. A larger, longer trial could determine whether this treatment also reduces fracture risk. <h3>Trial Registration</h3> clinicaltrials.gov Identifier: NCT00799617" @default.
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• W2591696989 date "2017-04-01" @default.
• W2591696989 modified "2023-10-18" @default.
• W2591696989 title "Effect of Testosterone Treatment on Volumetric Bone Density and Strength in Older Men With Low Testosterone" @default.
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• W2591696989 cites W1974568933 @default.
• W2591696989 cites W1984132051 @default.
• W2591696989 cites W1993415936 @default.
• W2591696989 cites W1997732940 @default.
• W2591696989 cites W1997807118 @default.
• W2591696989 cites W2000366267 @default.
• W2591696989 cites W2001078361 @default.
• W2591696989 cites W2008795349 @default.
• W2591696989 cites W2022029070 @default.
• W2591696989 cites W2025079080 @default.
• W2591696989 cites W2029097920 @default.
• W2591696989 cites W2032189326 @default.
• W2591696989 cites W2037189818 @default.
• W2591696989 cites W2040129532 @default.
• W2591696989 cites W2045765808 @default.
• W2591696989 cites W2065438227 @default.
• W2591696989 cites W2066186216 @default.
• W2591696989 cites W2071426095 @default.
• W2591696989 cites W2075559482 @default.
• W2591696989 cites W2079341234 @default.
• W2591696989 cites W2080047197 @default.
• W2591696989 cites W2113264234 @default.
• W2591696989 cites W2120668644 @default.
• W2591696989 cites W2127219068 @default.
• W2591696989 cites W2129550487 @default.
• W2591696989 cites W2134710844 @default.
• W2591696989 cites W2135959338 @default.
• W2591696989 cites W2139893960 @default.
• W2591696989 cites W2143514874 @default.
• W2591696989 cites W2144000500 @default.
• W2591696989 cites W2150101787 @default.
• W2591696989 cites W2155228880 @default.
• W2591696989 cites W2162514583 @default.
• W2591696989 cites W2163320305 @default.
• W2591696989 cites W2164227560 @default.
• W2591696989 cites W2276919011 @default.
• W2591696989 cites W2321613759 @default.
• W2591696989 cites W2324075496 @default.
• W2591696989 cites W2324158400 @default.
• W2591696989 cites W2467022164 @default.
• W2591696989 cites W4246593467 @default.
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• W2591696989 doi "https://doi.org/10.1001/jamainternmed.2016.9539" @default.
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