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- W2591757282 abstract "In this Opinion article, Schneideret al. outline tissue- and cell type-specific differences in tumorigenesis and the organization of oncogenic signalling pathways, and discuss the implications of our understanding of tissue context on molecularly targeted therapy and clinical trial design. How can we treat cancer more effectively? Traditionally, tumours from the same anatomical site are treated as one tumour entity. This concept has been challenged by recent breakthroughs in cancer genomics and translational research that have enabled molecular tumour profiling. The identification and validation of cancer drivers that are shared between different tumour types, spurred the new paradigm to target driver pathways across anatomical sites by off-label drug use, or within so-called basket or umbrella trials which are designed to test whether molecular alterations in one tumour entity can be extrapolated to all others. However, recent clinical and preclinical studies suggest that there are tissue- and cell type-specific differences in tumorigenesis and the organization of oncogenic signalling pathways. In this Opinion article, we focus on the molecular, cellular, systemic and environmental determinants of organ-specific tumorigenesis and the mechanisms of context-specific oncogenic signalling outputs. Investigation, recognition and in-depth biological understanding of these differences will be vital for the design of next-generation clinical trials and the implementation of molecularly guided cancer therapies in the future." @default.
- W2591757282 created "2017-03-16" @default.
- W2591757282 creator A5082231210 @default.
- W2591757282 creator A5084866392 @default.
- W2591757282 creator A5089219567 @default.
- W2591757282 creator A5090240499 @default.
- W2591757282 date "2017-03-03" @default.
- W2591757282 modified "2023-10-14" @default.
- W2591757282 title "Tissue-specific tumorigenesis: context matters" @default.
- W2591757282 cites W1198541923 @default.
- W2591757282 cites W1485363977 @default.
- W2591757282 cites W1495953741 @default.
- W2591757282 cites W1498931318 @default.
- W2591757282 cites W1504535992 @default.
- W2591757282 cites W1518329800 @default.
- W2591757282 cites W1524676616 @default.
- W2591757282 cites W1542825292 @default.
- W2591757282 cites W1552266425 @default.
- W2591757282 cites W1585504346 @default.
- W2591757282 cites W1601755300 @default.
- W2591757282 cites W1611210979 @default.
- W2591757282 cites W1692777765 @default.
- W2591757282 cites W1782443628 @default.
- W2591757282 cites W1846586690 @default.
- W2591757282 cites W1852268451 @default.
- W2591757282 cites W1856114115 @default.
- W2591757282 cites W1923410233 @default.
- W2591757282 cites W1940241680 @default.
- W2591757282 cites W1950829641 @default.
- W2591757282 cites W1959965398 @default.
- W2591757282 cites W1960656448 @default.
- W2591757282 cites W1965037168 @default.
- W2591757282 cites W1965887568 @default.
- W2591757282 cites W1966684685 @default.
- W2591757282 cites W1968295028 @default.
- W2591757282 cites W1968877074 @default.
- W2591757282 cites W1969201526 @default.
- W2591757282 cites W1969466735 @default.
- W2591757282 cites W1970881410 @default.
- W2591757282 cites W1971578941 @default.
- W2591757282 cites W1971819775 @default.
- W2591757282 cites W1971875278 @default.
- W2591757282 cites W1972476556 @default.
- W2591757282 cites W1972616341 @default.
- W2591757282 cites W1975493557 @default.
- W2591757282 cites W1976692257 @default.
- W2591757282 cites W1978148663 @default.
- W2591757282 cites W1978281808 @default.
- W2591757282 cites W1979355061 @default.
- W2591757282 cites W1981284988 @default.
- W2591757282 cites W1988476050 @default.
- W2591757282 cites W1988782755 @default.
- W2591757282 cites W1989456683 @default.
- W2591757282 cites W1992411393 @default.
- W2591757282 cites W1992995822 @default.
- W2591757282 cites W1993236149 @default.
- W2591757282 cites W1994987533 @default.
- W2591757282 cites W1996583924 @default.
- W2591757282 cites W1999716018 @default.
- W2591757282 cites W2002689737 @default.
- W2591757282 cites W2003760677 @default.
- W2591757282 cites W2004916962 @default.
- W2591757282 cites W2006070956 @default.
- W2591757282 cites W2007040134 @default.
- W2591757282 cites W2007179675 @default.
- W2591757282 cites W2009603041 @default.
- W2591757282 cites W2009720434 @default.
- W2591757282 cites W2011566841 @default.
- W2591757282 cites W2012124753 @default.
- W2591757282 cites W2014881369 @default.
- W2591757282 cites W2015015957 @default.
- W2591757282 cites W2015619266 @default.
- W2591757282 cites W2016661249 @default.
- W2591757282 cites W2016853666 @default.
- W2591757282 cites W2018825948 @default.
- W2591757282 cites W2019205168 @default.
- W2591757282 cites W2020624823 @default.
- W2591757282 cites W2021469872 @default.
- W2591757282 cites W2026496528 @default.
- W2591757282 cites W2027284694 @default.
- W2591757282 cites W2028433016 @default.
- W2591757282 cites W2028691872 @default.
- W2591757282 cites W2029525421 @default.
- W2591757282 cites W2029764427 @default.
- W2591757282 cites W2031300004 @default.
- W2591757282 cites W2031505107 @default.
- W2591757282 cites W2033278321 @default.
- W2591757282 cites W2033430197 @default.
- W2591757282 cites W2033990985 @default.
- W2591757282 cites W2034641989 @default.
- W2591757282 cites W2034893372 @default.
- W2591757282 cites W2035252444 @default.
- W2591757282 cites W2035394593 @default.
- W2591757282 cites W2036659083 @default.
- W2591757282 cites W2038683568 @default.
- W2591757282 cites W2041594739 @default.
- W2591757282 cites W2041988645 @default.
- W2591757282 cites W2042793731 @default.