Matches in SemOpenAlex for { <https://semopenalex.org/work/W2591768167> ?p ?o ?g. }
- W2591768167 endingPage "14" @default.
- W2591768167 startingPage "1" @default.
- W2591768167 abstract "Diapause, an alternative developmental pathway characterized by changes in developmental timing and metabolism, is coordinated by molecular mechanisms that are not completely understood. MicroRNA (miRNA) mediated gene silencing is emerging as a key component of animal development and may have a significant role in initiating, maintaining, and terminating insect diapause. In the present study, we test this possibility by using high-throughput sequencing and qRT-PCR to discover diapause-related shifts in miRNA abundance in the flesh fly, Sarcophaga bullata. We identified ten evolutionarily conserved miRNAs that were differentially expressed in diapausing pupae compared to their nondiapausing counterparts. miR-289-5p and miR-1-3p were overexpressed in diapausing pupae and may be responsible for silencing expression of candidate genes during diapause. miR-9c-5p, miR-13b-3p, miR-31a-5p, miR-92b-3p, miR-275-3p, miR-276a-3p, miR-277-3p, and miR-305-5p were underexpressed in diapausing pupae and may contribute to increased expression of heat shock proteins and other factors necessary for the enhanced environmental stress-response that is a feature of diapause. In S. bullata, a maternal effect blocks the programming of diapause in progeny of females that have experienced pupal diapause, and in this study we report that several miRNAs, including miR-263a-5p, miR-100-5p, miR-125-5p, and let-7-5p were significantly overexpressed in such nondiapausing flies and may prevent entry into diapause. Together these miRNAs appear to be integral to the molecular processes that mediate entry into diapause." @default.
- W2591768167 created "2017-03-16" @default.
- W2591768167 creator A5025777931 @default.
- W2591768167 creator A5042129713 @default.
- W2591768167 creator A5054177094 @default.
- W2591768167 date "2017-05-01" @default.
- W2591768167 modified "2023-10-12" @default.
- W2591768167 title "Changes in microRNA abundance may regulate diapause in the flesh fly, Sarcophaga bullata" @default.
- W2591768167 cites W1233377976 @default.
- W2591768167 cites W1514286294 @default.
- W2591768167 cites W1854999641 @default.
- W2591768167 cites W1887664968 @default.
- W2591768167 cites W1918299928 @default.
- W2591768167 cites W1964837069 @default.
- W2591768167 cites W1965854786 @default.
- W2591768167 cites W1966396145 @default.
- W2591768167 cites W1966401030 @default.
- W2591768167 cites W1969822495 @default.
- W2591768167 cites W1973320270 @default.
- W2591768167 cites W1973726689 @default.
- W2591768167 cites W1976021976 @default.
- W2591768167 cites W1980766219 @default.
- W2591768167 cites W1982550206 @default.
- W2591768167 cites W1990462722 @default.
- W2591768167 cites W1993156433 @default.
- W2591768167 cites W1996638581 @default.
- W2591768167 cites W2001477152 @default.
- W2591768167 cites W2002519602 @default.
- W2591768167 cites W2004791359 @default.
- W2591768167 cites W2005676064 @default.
- W2591768167 cites W2006247279 @default.
- W2591768167 cites W2025640769 @default.
- W2591768167 cites W2029771610 @default.
- W2591768167 cites W2030946149 @default.
- W2591768167 cites W2032349626 @default.
- W2591768167 cites W2033419682 @default.
- W2591768167 cites W2034222437 @default.
- W2591768167 cites W2036171395 @default.
- W2591768167 cites W2039415806 @default.
- W2591768167 cites W2040667858 @default.
- W2591768167 cites W2045281814 @default.
- W2591768167 cites W2046930479 @default.
- W2591768167 cites W2047232301 @default.
- W2591768167 cites W2051773226 @default.
- W2591768167 cites W2057460504 @default.
- W2591768167 cites W2060591569 @default.
- W2591768167 cites W2067167952 @default.
- W2591768167 cites W2069009920 @default.
- W2591768167 cites W2070593887 @default.
- W2591768167 cites W2071501400 @default.
- W2591768167 cites W2077327925 @default.
- W2591768167 cites W2079439679 @default.
- W2591768167 cites W2079467486 @default.
- W2591768167 cites W2084723041 @default.
- W2591768167 cites W2088938600 @default.
- W2591768167 cites W2089001345 @default.
- W2591768167 cites W2089071639 @default.
- W2591768167 cites W2089452537 @default.
- W2591768167 cites W2092513900 @default.
- W2591768167 cites W2093074701 @default.
- W2591768167 cites W2095357850 @default.
- W2591768167 cites W2096840933 @default.
- W2591768167 cites W2101952636 @default.
- W2591768167 cites W2103017472 @default.
- W2591768167 cites W2110256992 @default.
- W2591768167 cites W2117719756 @default.
- W2591768167 cites W2120141187 @default.
- W2591768167 cites W2123079914 @default.
- W2591768167 cites W2123150425 @default.
- W2591768167 cites W2123735157 @default.
- W2591768167 cites W2124579236 @default.
- W2591768167 cites W2140882426 @default.
- W2591768167 cites W2141500037 @default.
- W2591768167 cites W2143621972 @default.
- W2591768167 cites W2148995089 @default.
- W2591768167 cites W2150494200 @default.
- W2591768167 cites W2157308941 @default.
- W2591768167 cites W2162675434 @default.
- W2591768167 cites W2166243815 @default.
- W2591768167 cites W2166894044 @default.
- W2591768167 cites W2170143327 @default.
- W2591768167 cites W2185131077 @default.
- W2591768167 cites W2228218040 @default.
- W2591768167 cites W2257443090 @default.
- W2591768167 cites W2290069354 @default.
- W2591768167 cites W2336586078 @default.
- W2591768167 cites W2338409095 @default.
- W2591768167 cites W2395411678 @default.
- W2591768167 cites W2410986138 @default.
- W2591768167 cites W2427791329 @default.
- W2591768167 cites W2463291814 @default.
- W2591768167 cites W2497332971 @default.
- W2591768167 cites W4245701839 @default.
- W2591768167 doi "https://doi.org/10.1016/j.ibmb.2017.03.002" @default.
- W2591768167 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28300610" @default.
- W2591768167 hasPublicationYear "2017" @default.
- W2591768167 type Work @default.
- W2591768167 sameAs 2591768167 @default.