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• W2591781966 abstract "Ferroptosis is a recently discovered form of regulated necrosis that involves iron-dependent lipid peroxidation. How cells die once ferroptosis is triggered remains unclear. Ferroptosis is hypothesized to require three critical events: (1) accumulation of redox-active iron, (2) glutathione depletion, and (3) lipid peroxidation. It is proposed that these three events must unfold simultaneously because stopping any critical event also stops ferroptosis. These events are hypothesized to amplify in severity through positive feedback loops. The cause of death in ferroptosis is therefore the synergistic combination of antioxidant depletion, iron toxicity, and membrane denaturation. The relevance of these feedback loops for cancer and neurodegenerative therapies is discussed." @default.
• W2591781966 created "2017-03-16" @default.
• W2591781966 creator A5043012873 @default.
• W2591781966 date "2017-04-01" @default.
• W2591781966 modified "2023-10-09" @default.
• W2591781966 title "Iron accumulation, glutathione depletion, and lipid peroxidation must occur simultaneously during ferroptosis and are mutually amplifying events" @default.
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• W2591781966 doi "https://doi.org/10.1016/j.mehy.2017.02.017" @default.
• W2591781966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28351498" @default.
• W2591781966 hasPublicationYear "2017" @default.
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