FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2591852334> ?p ?o ?g. }

• W2591852334 abstract "Abstract Objectives Root resorption is a common phenomenon presented in periodontitis and orthodontic treatment, both of which are accompanied by an elevated TNF ‐α expression level in the periodontal tissues. Previously, we proved that TNF ‐α showed an inhibitory effect on cementoblast differentiation, mineralization and proliferation. However, the effect of TNF ‐α on Runx2 and osteoprotegerin ( OPG ) expression remains undetermined. This study aimed to identify the influence of TNF ‐α on Runx2 and OPG expression in cementoblasts and to test whether BMP ‐2,‐4,‐6,‐7 would affect TNF ‐α‐regulated Runx2 and OPG . Materials and methods An immortalized murine cementoblast cell line OCCM ‐30 was used in this study. The expression of Runx2 and OPG were examined by qRT ‐ PCR after stimulating cells with TNF ‐α. The role of signalling pathways, including MAPK , PI 3K‐Akt and NF ‐κB, were studied with the use of specific inhibitors. Cells were treated with TNF ‐α in combination with BMP ‐2,‐4,‐6 or ‐7, then the expression of Runx2 and OPG , the activity of MAPK and NF ‐κB pathways, and the proliferation ability were evaluated by qRT ‐ PCR , Western blot and MTS assay respectively. Results TNF ‐α inhibited Runx2 and OPG mRNA s in OCCM ‐30 cells, and the inhibitory effects were further aggravated by blocking p38 MAPK or NF ‐κB pathway. TNF ‐α‐inhibited Runx2 and OPG were up‐regulated by BMP ‐4. The p38 MAPK and Erk1/2 pathways were further activated by the combined treatment of BMP ‐4 and TNF ‐α compared with TNF ‐α alone. Finally, the TNF ‐α‐suppressed proliferation was not obviously affected by BMP ‐2,‐4,‐6 or ‐7. Conclusions TNF ‐α inhibited Runx2 and OPG in cementoblasts, and the p38 MAPK and NF ‐κB pathways acted in a negative‐feedback way to attenuate the inhibitory effects. TNF‐α‐inhibited Runx2 and OPG could be effectively up‐regulated by BMP ‐4; however, further investigations are needed to fully elaborate the underlying mechanisms." @default.
• W2591852334 created "2017-03-16" @default.
• W2591852334 creator A5000488223 @default.
• W2591852334 creator A5046819849 @default.
• W2591852334 creator A5050613147 @default.
• W2591852334 creator A5067856747 @default.
• W2591852334 creator A5073936760 @default.
• W2591852334 creator A5078452465 @default.
• W2591852334 date "2017-02-28" @default.
• W2591852334 modified "2023-10-10" @default.
• W2591852334 title "Regulatory effects of bone morphogenetic protein-4 on tumour necrosis factor-α-suppressed Runx2 and osteoprotegerin expression in cementoblasts" @default.
• W2591852334 cites W1823755123 @default.
• W2591852334 cites W1967580136 @default.
• W2591852334 cites W1971384090 @default.
• W2591852334 cites W1971912573 @default.
• W2591852334 cites W1974915155 @default.
• W2591852334 cites W1981323152 @default.
• W2591852334 cites W1981921524 @default.
• W2591852334 cites W1983608196 @default.
• W2591852334 cites W1990108686 @default.
• W2591852334 cites W1994596418 @default.
• W2591852334 cites W1996013670 @default.
• W2591852334 cites W1999224279 @default.
• W2591852334 cites W2000647744 @default.
• W2591852334 cites W2002109462 @default.
• W2591852334 cites W2006385099 @default.
• W2591852334 cites W2016531821 @default.
• W2591852334 cites W2016685210 @default.
• W2591852334 cites W2022636219 @default.
• W2591852334 cites W2028074392 @default.
• W2591852334 cites W2029090980 @default.
• W2591852334 cites W2045069300 @default.
• W2591852334 cites W2045203256 @default.
• W2591852334 cites W2047790628 @default.
• W2591852334 cites W2050070999 @default.
• W2591852334 cites W2055846324 @default.
• W2591852334 cites W2057767897 @default.
• W2591852334 cites W2067801242 @default.
• W2591852334 cites W2072001793 @default.
• W2591852334 cites W2075690964 @default.
• W2591852334 cites W2077569332 @default.
• W2591852334 cites W2078344741 @default.
• W2591852334 cites W2085627522 @default.
• W2591852334 cites W2085755629 @default.
• W2591852334 cites W2096364286 @default.
• W2591852334 cites W2105160449 @default.
• W2591852334 cites W2107366133 @default.
• W2591852334 cites W2116862152 @default.
• W2591852334 cites W2118089919 @default.
• W2591852334 cites W2122367477 @default.
• W2591852334 cites W2125979453 @default.
• W2591852334 cites W2127708339 @default.
• W2591852334 cites W2128357004 @default.
• W2591852334 cites W2129446718 @default.
• W2591852334 cites W2142939199 @default.
• W2591852334 cites W2149488681 @default.
• W2591852334 cites W2159756188 @default.
• W2591852334 cites W2161329557 @default.
• W2591852334 doi "https://doi.org/10.1111/cpr.12344" @default.
• W2591852334 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6529144" @default.
• W2591852334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28244247" @default.
• W2591852334 hasPublicationYear "2017" @default.
• W2591852334 type Work @default.
• W2591852334 sameAs 2591852334 @default.
• W2591852334 citedByCount "12" @default.
• W2591852334 countsByYear W25918523342018 @default.
• W2591852334 countsByYear W25918523342019 @default.
• W2591852334 countsByYear W25918523342020 @default.
• W2591852334 countsByYear W25918523342021 @default.
• W2591852334 countsByYear W25918523342023 @default.
• W2591852334 crossrefType "journal-article" @default.
• W2591852334 hasAuthorship W2591852334A5000488223 @default.
• W2591852334 hasAuthorship W2591852334A5046819849 @default.
• W2591852334 hasAuthorship W2591852334A5050613147 @default.
• W2591852334 hasAuthorship W2591852334A5067856747 @default.
• W2591852334 hasAuthorship W2591852334A5073936760 @default.
• W2591852334 hasAuthorship W2591852334A5078452465 @default.
• W2591852334 hasBestOaLocation W25918523341 @default.
• W2591852334 hasConcept C104317684 @default.
• W2591852334 hasConcept C126322002 @default.
• W2591852334 hasConcept C131075544 @default.
• W2591852334 hasConcept C134018914 @default.
• W2591852334 hasConcept C160160445 @default.
• W2591852334 hasConcept C170493617 @default.
• W2591852334 hasConcept C17991360 @default.
• W2591852334 hasConcept C181199279 @default.
• W2591852334 hasConcept C185592680 @default.
• W2591852334 hasConcept C199343813 @default.
• W2591852334 hasConcept C2776363554 @default.
• W2591852334 hasConcept C2776432469 @default.
• W2591852334 hasConcept C2777894202 @default.
• W2591852334 hasConcept C2779263046 @default.
• W2591852334 hasConcept C2780426850 @default.
• W2591852334 hasConcept C51551487 @default.
• W2591852334 hasConcept C55493867 @default.
• W2591852334 hasConcept C56302369 @default.
• W2591852334 hasConcept C57074206 @default.
• W2591852334 hasConcept C62478195 @default.
• W2591852334 hasConcept C673006 @default.
• W2591852334 hasConcept C71924100 @default.

• next