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- W2591909501 abstract "Although myasthenia gravis (MG) is a classic autoantibody-mediated disease, T cells are centrally involved in its pathogenesis. In recent years a number of studies have analyzed the role of CD4+ FoxP3+ regulatory T cells (Treg) in the disease with contradictory results. Here, the generation of Treg was significantly reduced in thymoma as compared to thymic hyperplasia and normal thymus tissue (p = 0.0002). In the peripheral blood, Treg subsets classified according to CD49d, HELIOS and CD45RA expression changed after thymectomy and in the long-term course of immunosuppression. Compared to healthy volunteers the frequency of CD45RA+ FoxP3low Treg was reduced in MG patients in general (p = 0.037) and in particular in patients without immunosuppression (p = 0.036). In our study, thymectomy and immunosuppressive treatment were associated with changes in Treg subpopulations. The reduced frequency of CD45RA+ FoxP3low Treg we observed in MG patients might play a role in MG pathogenesis." @default.
- W2591909501 created "2017-03-16" @default.
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- W2591909501 date "2017-06-01" @default.
- W2591909501 modified "2023-10-04" @default.
- W2591909501 title "CD4 + FoxP3 + T regulatory cell subsets in myasthenia gravis patients" @default.
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- W2591909501 doi "https://doi.org/10.1016/j.clim.2017.03.003" @default.
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