FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2592003306> ?p ?o ?g. }

• W2592003306 endingPage "825" @default.
• W2592003306 startingPage "810" @default.
• W2592003306 abstract "Thyroid tumors formerly classified as non-invasive encapsulated follicular variant of papillary thyroid carcinoma were recently renamed ‘non-invasive follicular thyroid neoplasm with papillary-like nuclear features’. The current study investigated the frequency of lymph node metastasis and mutational profile of encapsulated follicular variant in the setting of a clinical practice where central neck dissection was the standard of practice. We defined the impact of rigid diagnostic criteria by regrouping such tumors based on the complete absence of papillae or presence of ≤1% papillae. Of a total of 6,269 papillary thyroid carcinomas, 152 tumors fulfilled the criteria for encapsulated follicular variant. The results were stratified according to two different diagnostic cutoff criteria with respect to the extent of papillae. When the cutoff of 1% papillae was used, the rates of lymph node metastasis and BRAFV600E mutation were 3% and 10% in non-invasive tumors and 9% and 4% in invasive tumors, respectively. Despite the lack of invasive growth, one patient with BRAFV600E mutant-tumor displaying predominant follicular growth and subtle papillae developed a bone metastasis. When absence of papillary structure was applied as rigid diagnostic criteria, no BRAFV600E mutation was found in all tumors. However, central lymph node micrometastasis still occurred in 3% of non-invasive tumors. Non-V600E BRAF and RAS mutations were detected in 4% and 47% of non-invasive tumors, respectively. Our findings suggest that non-invasive follicular thyroid neoplasm with papillary-like nuclear features should not be regarded as a benign thyroid neoplasm as it can present with lymph node micrometastasis and should not be diagnosed in the presence of even a single papillary structure. Our findings underscore the original American Thyroid Association recommendation that defined non-invasive encapsulated follicular variants as low risk thyroid cancers. Clinical surveillance similar to low risk differentiated thyroid cancers and capture of this diagnostic category by Cancer Registries should be considered." @default.
• W2592003306 created "2017-03-16" @default.
• W2592003306 creator A5017460777 @default.
• W2592003306 creator A5033998540 @default.
• W2592003306 creator A5042223207 @default.
• W2592003306 creator A5043744368 @default.
• W2592003306 creator A5049572478 @default.
• W2592003306 date "2017-06-01" @default.
• W2592003306 modified "2023-10-17" @default.
• W2592003306 title "Molecular correlates and rate of lymph node metastasis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features and invasive follicular variant papillary thyroid carcinoma: the impact of rigid criteria to distinguish non-invasive follicular thyroid neoplasm with papillary-like nuclear features" @default.
• W2592003306 cites W1977628037 @default.
• W2592003306 cites W1982660784 @default.
• W2592003306 cites W1997166401 @default.
• W2592003306 cites W2004749577 @default.
• W2592003306 cites W2011699883 @default.
• W2592003306 cites W2013113729 @default.
• W2592003306 cites W2019924347 @default.
• W2592003306 cites W2022035145 @default.
• W2592003306 cites W2027424680 @default.
• W2592003306 cites W2033882181 @default.
• W2592003306 cites W2037458235 @default.
• W2592003306 cites W2043077723 @default.
• W2592003306 cites W2047189534 @default.
• W2592003306 cites W2053476612 @default.
• W2592003306 cites W2054939147 @default.
• W2592003306 cites W2057387108 @default.
• W2592003306 cites W2062836415 @default.
• W2592003306 cites W2066662508 @default.
• W2592003306 cites W2068668619 @default.
• W2592003306 cites W2074891053 @default.
• W2592003306 cites W2092724101 @default.
• W2592003306 cites W2093917846 @default.
• W2592003306 cites W2107134635 @default.
• W2592003306 cites W2109009679 @default.
• W2592003306 cites W2111805924 @default.
• W2592003306 cites W2145150141 @default.
• W2592003306 cites W2148261989 @default.
• W2592003306 cites W2153226053 @default.
• W2592003306 cites W2154066136 @default.
• W2592003306 cites W2156676658 @default.
• W2592003306 cites W2158792987 @default.
• W2592003306 cites W2237074892 @default.
• W2592003306 cites W2279661897 @default.
• W2592003306 cites W2312782750 @default.
• W2592003306 cites W2336313337 @default.
• W2592003306 cites W2337882641 @default.
• W2592003306 cites W2520304492 @default.
• W2592003306 doi "https://doi.org/10.1038/modpathol.2017.9" @default.
• W2592003306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28281551" @default.
• W2592003306 hasPublicationYear "2017" @default.
• W2592003306 type Work @default.
• W2592003306 sameAs 2592003306 @default.
• W2592003306 citedByCount "152" @default.
• W2592003306 countsByYear W25920033062017 @default.
• W2592003306 countsByYear W25920033062018 @default.
• W2592003306 countsByYear W25920033062019 @default.
• W2592003306 countsByYear W25920033062020 @default.
• W2592003306 countsByYear W25920033062021 @default.
• W2592003306 countsByYear W25920033062022 @default.
• W2592003306 countsByYear W25920033062023 @default.
• W2592003306 crossrefType "journal-article" @default.
• W2592003306 hasAuthorship W2592003306A5017460777 @default.
• W2592003306 hasAuthorship W2592003306A5033998540 @default.
• W2592003306 hasAuthorship W2592003306A5042223207 @default.
• W2592003306 hasAuthorship W2592003306A5043744368 @default.
• W2592003306 hasAuthorship W2592003306A5049572478 @default.
• W2592003306 hasBestOaLocation W25920033061 @default.
• W2592003306 hasConcept C121608353 @default.
• W2592003306 hasConcept C126322002 @default.
• W2592003306 hasConcept C142724271 @default.
• W2592003306 hasConcept C187785154 @default.
• W2592003306 hasConcept C2778057883 @default.
• W2592003306 hasConcept C2778123414 @default.
• W2592003306 hasConcept C2779013556 @default.
• W2592003306 hasConcept C2780399592 @default.
• W2592003306 hasConcept C2780849966 @default.
• W2592003306 hasConcept C2993294228 @default.
• W2592003306 hasConcept C526584372 @default.
• W2592003306 hasConcept C71924100 @default.
• W2592003306 hasConceptScore W2592003306C121608353 @default.
• W2592003306 hasConceptScore W2592003306C126322002 @default.
• W2592003306 hasConceptScore W2592003306C142724271 @default.
• W2592003306 hasConceptScore W2592003306C187785154 @default.
• W2592003306 hasConceptScore W2592003306C2778057883 @default.
• W2592003306 hasConceptScore W2592003306C2778123414 @default.
• W2592003306 hasConceptScore W2592003306C2779013556 @default.
• W2592003306 hasConceptScore W2592003306C2780399592 @default.
• W2592003306 hasConceptScore W2592003306C2780849966 @default.
• W2592003306 hasConceptScore W2592003306C2993294228 @default.
• W2592003306 hasConceptScore W2592003306C526584372 @default.
• W2592003306 hasConceptScore W2592003306C71924100 @default.
• W2592003306 hasIssue "6" @default.
• W2592003306 hasLocation W25920033061 @default.
• W2592003306 hasLocation W25920033062 @default.
• W2592003306 hasOpenAccess W2592003306 @default.
• W2592003306 hasPrimaryLocation W25920033061 @default.
• W2592003306 hasRelatedWork W16279533 @default.
• W2592003306 hasRelatedWork W1983640290 @default.

• next