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- W2592019987 endingPage "16.2017" @default.
- W2592019987 startingPage "ENEURO.0255" @default.
- W2592019987 abstract "Abstract Calcium signaling controls many key processes in neurons, including gene expression, axon guidance, and synaptic plasticity. In contrast to calcium influx through voltage- or neurotransmitter-gated channels, regulatory pathways that control store-operated calcium entry (SOCE) in neurons are poorly understood. Here, we report a transcriptional control of Stim1 (stromal interaction molecule 1) gene, which is a major sensor of endoplasmic reticulum (ER) calcium levels and a regulator of SOCE. By using a genome-wide chromatin immunoprecipitation and sequencing approach in mice, we find that NEUROD2, a neurogenic transcription factor, binds to an intronic element within the Stim1 gene. We show that NEUROD2 limits Stim1 expression in cortical neurons and consequently fine-tunes the SOCE response upon depletion of ER calcium. Our findings reveal a novel mechanism that regulates neuronal calcium homeostasis during cortical development." @default.
- W2592019987 created "2017-03-16" @default.
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- W2592019987 date "2017-01-01" @default.
- W2592019987 modified "2023-10-06" @default.
- W2592019987 title "NEUROD2 Regulates<i>Stim1</i>Expression and Store-Operated Calcium Entry in Cortical Neurons" @default.
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- W2592019987 cites W1907909844 @default.
- W2592019987 cites W1909964525 @default.
- W2592019987 cites W1966900376 @default.
- W2592019987 cites W1968116673 @default.
- W2592019987 cites W1977419289 @default.
- W2592019987 cites W1978593035 @default.
- W2592019987 cites W1985452716 @default.
- W2592019987 cites W1986531910 @default.
- W2592019987 cites W1992416292 @default.
- W2592019987 cites W1997578813 @default.
- W2592019987 cites W2001917660 @default.
- W2592019987 cites W2003653107 @default.
- W2592019987 cites W2003829187 @default.
- W2592019987 cites W2006852136 @default.
- W2592019987 cites W2007491346 @default.
- W2592019987 cites W2027917639 @default.
- W2592019987 cites W2031958964 @default.
- W2592019987 cites W2032321721 @default.
- W2592019987 cites W2038901812 @default.
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- W2592019987 doi "https://doi.org/10.1523/eneuro.0255-16.2017" @default.
- W2592019987 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5343279" @default.
- W2592019987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28303257" @default.
- W2592019987 hasPublicationYear "2017" @default.
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