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- W2592022103 abstract "This chapter focuses on immune effects and clinical events thought likely to be immune in origin, which involve transfusion's effects on innate or adaptive cellular immunity. It reviews the randomised trials that have definitively demonstrated that transfusion causes increases in nosocomial infection after surgery because these effects can be partially mitigated by leucocyte reduction, autologous transfusion and restrictive transfusion practices. The chapter summarises other effects based upon observational and cohort studies, as well as animal models. The proposed immunological mechanisms underlying these findings, inferred from in vitro and animal model experiments, are also summarised. The question of storage age of red cells as mediators of transfusion immunomodulation is also addressed, along with future studies needed to better understand the mechanisms of transfusion immunomodulation and further mitigate the immunological toxicity of allogeneic transfusions." @default.
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- W2592022103 date "2017-03-10" @default.
- W2592022103 modified "2023-10-16" @default.
- W2592022103 title "Transfusion‐Induced Immunomodulation" @default.
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- W2592022103 doi "https://doi.org/10.1002/9781119129431.ch12" @default.
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