FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2592053233> ?p ?o ?g. }

• W2592053233 endingPage "1935" @default.
• W2592053233 startingPage "1926" @default.
• W2592053233 abstract "Prophylactic antipyretic use during pediatric vaccination is common. This study assessed whether paracetamol or ibuprofen prophylaxis interfere with immune responses to the 13-valent pneumococcal conjugate vaccine (PCV13) given concomitantly with the combined DTaP/HBV/IPV/Hib vaccine.Subjects received prophylactic paracetamol or ibuprofen at 0, 6-8, and 12-16 h after vaccination, or 6-8 and 12-16 h after vaccination at 2, 3, 4, and 12months of age. At 5 and 13months, immune responses were evaluated versus responses in controls who received no prophylaxis.After the infant series, paracetamol recipients had lower levels of circulating serotype-specific pneumococcal anticapsular immunoglobulin G than controls, reaching significance (P<0.0125) for 5 serotypes (serotypes 3, 4, 5, 6B, and 23F) when paracetamol was started at vaccination. Opsonophagocytic activity assay (OPA) results were similar between groups. Ibuprofen did not affect pneumococcal responses, but significantly (P<0.0125) reduced antibody responses to pertussis filamentous hemagglutinin and tetanus antigens after the infant series when started at vaccination. No differences were observed for any group after the toddler dose.Prophylactic antipyretics affect immune responses to vaccines; these effects vary depending on the vaccine, antipyretic agent, and time of administration. In infants, paracetamol may interfere with immune responses to pneumococcal antigens, and ibuprofen may reduce responses to pertussis and tetanus antigens. The use of antipyretics for fever prophylaxis during infant vaccination merits careful consideration. ClinicalTrials.gov identifier: NCT01392378https://clinicaltrials.gov/ct2/show/NCT01392378?term=NCT01392378&rank=1." @default.
• W2592053233 created "2017-03-16" @default.
• W2592053233 creator A5004659933 @default.
• W2592053233 creator A5015105121 @default.
• W2592053233 creator A5025869429 @default.
• W2592053233 creator A5030526501 @default.
• W2592053233 creator A5031381958 @default.
• W2592053233 creator A5038494072 @default.
• W2592053233 creator A5044804619 @default.
• W2592053233 creator A5050974548 @default.
• W2592053233 creator A5051222200 @default.
• W2592053233 creator A5053447115 @default.
• W2592053233 creator A5056359451 @default.
• W2592053233 creator A5059910961 @default.
• W2592053233 creator A5067206456 @default.
• W2592053233 creator A5072267962 @default.
• W2592053233 creator A5073726801 @default.
• W2592053233 creator A5086524484 @default.
• W2592053233 creator A5089250701 @default.
• W2592053233 creator A5089678920 @default.
• W2592053233 date "2017-04-01" @default.
• W2592053233 modified "2023-10-02" @default.
• W2592053233 title "A randomized study of fever prophylaxis and the immunogenicity of routine pediatric vaccinations" @default.
• W2592053233 cites W1507946309 @default.
• W2592053233 cites W1943307706 @default.
• W2592053233 cites W1974413001 @default.
• W2592053233 cites W1985833024 @default.
• W2592053233 cites W1990877936 @default.
• W2592053233 cites W1991656466 @default.
• W2592053233 cites W1997970219 @default.
• W2592053233 cites W2024634994 @default.
• W2592053233 cites W2029016985 @default.
• W2592053233 cites W2030612815 @default.
• W2592053233 cites W2034828959 @default.
• W2592053233 cites W2035758731 @default.
• W2592053233 cites W2037786313 @default.
• W2592053233 cites W2039072529 @default.
• W2592053233 cites W2041891483 @default.
• W2592053233 cites W2052180986 @default.
• W2592053233 cites W2067845278 @default.
• W2592053233 cites W2068380190 @default.
• W2592053233 cites W2081829752 @default.
• W2592053233 cites W2089041217 @default.
• W2592053233 cites W2091532170 @default.
• W2592053233 cites W2098502913 @default.
• W2592053233 cites W2104523370 @default.
• W2592053233 cites W2105803657 @default.
• W2592053233 cites W2113333577 @default.
• W2592053233 cites W2116627833 @default.
• W2592053233 cites W2118054413 @default.
• W2592053233 cites W2123619196 @default.
• W2592053233 cites W2126536429 @default.
• W2592053233 cites W2146477509 @default.
• W2592053233 cites W2151165850 @default.
• W2592053233 cites W2155601189 @default.
• W2592053233 cites W2158965885 @default.
• W2592053233 cites W2158985300 @default.
• W2592053233 cites W2463724434 @default.
• W2592053233 cites W2472236449 @default.
• W2592053233 cites W4253839903 @default.
• W2592053233 doi "https://doi.org/10.1016/j.vaccine.2017.02.035" @default.
• W2592053233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28262330" @default.
• W2592053233 hasPublicationYear "2017" @default.
• W2592053233 type Work @default.
• W2592053233 sameAs 2592053233 @default.
• W2592053233 citedByCount "25" @default.
• W2592053233 countsByYear W25920532332017 @default.
• W2592053233 countsByYear W25920532332018 @default.
• W2592053233 countsByYear W25920532332019 @default.
• W2592053233 countsByYear W25920532332020 @default.
• W2592053233 countsByYear W25920532332021 @default.
• W2592053233 countsByYear W25920532332022 @default.
• W2592053233 countsByYear W25920532332023 @default.
• W2592053233 crossrefType "journal-article" @default.
• W2592053233 hasAuthorship W2592053233A5004659933 @default.
• W2592053233 hasAuthorship W2592053233A5015105121 @default.
• W2592053233 hasAuthorship W2592053233A5025869429 @default.
• W2592053233 hasAuthorship W2592053233A5030526501 @default.
• W2592053233 hasAuthorship W2592053233A5031381958 @default.
• W2592053233 hasAuthorship W2592053233A5038494072 @default.
• W2592053233 hasAuthorship W2592053233A5044804619 @default.
• W2592053233 hasAuthorship W2592053233A5050974548 @default.
• W2592053233 hasAuthorship W2592053233A5051222200 @default.
• W2592053233 hasAuthorship W2592053233A5053447115 @default.
• W2592053233 hasAuthorship W2592053233A5056359451 @default.
• W2592053233 hasAuthorship W2592053233A5059910961 @default.
• W2592053233 hasAuthorship W2592053233A5067206456 @default.
• W2592053233 hasAuthorship W2592053233A5072267962 @default.
• W2592053233 hasAuthorship W2592053233A5073726801 @default.
• W2592053233 hasAuthorship W2592053233A5086524484 @default.
• W2592053233 hasAuthorship W2592053233A5089250701 @default.
• W2592053233 hasAuthorship W2592053233A5089678920 @default.
• W2592053233 hasBestOaLocation W25920532331 @default.
• W2592053233 hasConcept C203014093 @default.
• W2592053233 hasConcept C22070199 @default.
• W2592053233 hasConcept C2778866548 @default.
• W2592053233 hasConcept C2779252780 @default.
• W2592053233 hasConcept C2779841045 @default.

• next