FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2592062735> ?p ?o ?g. }

• W2592062735 abstract "Norovirus GII.4 is a major cause of global outbreaks of viral gastroenteritis in humans, and has evolved by antigenic changes under the constantly changing human herd immunity. Major shift in the pandemic GII.4 strain periodically occurs concomitant with changes in the antigenic capsid protein VP1. However, how the newly emerged strain evolves after the onset of pandemic remains unclear. To address this issue, we examined molecular evolution of a pandemic lineage, termed the GII.4_2006b, by using the full-length viral genome and VP1 sequences (n = 317) from stools collected at 20 sites in Japan between 2006 and 2011. Phylogenetic tree showed a radial diversification of the genome sequences of GII.4_2006b, suggesting a rapid genetic diversification of the GII.4_2006b population from a few ancestral variants. Impressively, amino acid sequences of the variable VP1 in given seasons remained as homogeneous as those of viral enzymes under annual increase in the nucleotide diversity in the VP1 coding region. The Hamming distances between the earliest and subsequent variants indicate strong constraints on amino acid changes even for the highly variable P2 subdomain. These results show the presence of evolutionary constraints on the VP1 protein and viral enzymes, and suggest that these proteins gain near maximal levels of fitness benefits in humans around the onset of the outbreaks. These findings have implications for our understanding of molecular evolution, mechanisms of the periodic shifts in the pandemic NoV GII.4 strains, and control of the NoV GII.4 pandemic strain." @default.
• W2592062735 created "2017-03-16" @default.
• W2592062735 creator A5001280828 @default.
• W2592062735 creator A5003155821 @default.
• W2592062735 creator A5010120453 @default.
• W2592062735 creator A5015587865 @default.
• W2592062735 creator A5022274918 @default.
• W2592062735 creator A5041512038 @default.
• W2592062735 creator A5044603246 @default.
• W2592062735 creator A5065544054 @default.
• W2592062735 creator A5076980836 @default.
• W2592062735 date "2017-03-13" @default.
• W2592062735 modified "2023-10-16" @default.
• W2592062735 title "Evolutionary Constraints on the Norovirus Pandemic Variant GII.4_2006b over the Five-Year Persistence in Japan" @default.
• W2592062735 cites W118013854 @default.
• W2592062735 cites W1573702528 @default.
• W2592062735 cites W194351578 @default.
• W2592062735 cites W1964970561 @default.
• W2592062735 cites W1971304145 @default.
• W2592062735 cites W1985069865 @default.
• W2592062735 cites W1988912949 @default.
• W2592062735 cites W1993086912 @default.
• W2592062735 cites W1994053564 @default.
• W2592062735 cites W2001762003 @default.
• W2592062735 cites W2025301473 @default.
• W2592062735 cites W2035909460 @default.
• W2592062735 cites W2040345474 @default.
• W2592062735 cites W2042000843 @default.
• W2592062735 cites W2066032790 @default.
• W2592062735 cites W2068008645 @default.
• W2592062735 cites W2070335838 @default.
• W2592062735 cites W2071570482 @default.
• W2592062735 cites W2097036089 @default.
• W2592062735 cites W2101733889 @default.
• W2592062735 cites W2113585031 @default.
• W2592062735 cites W2126217050 @default.
• W2592062735 cites W2128027310 @default.
• W2592062735 cites W2129029652 @default.
• W2592062735 cites W2130788389 @default.
• W2592062735 cites W2132632499 @default.
• W2592062735 cites W2137804006 @default.
• W2592062735 cites W2142484721 @default.
• W2592062735 cites W2145102665 @default.
• W2592062735 cites W2145719673 @default.
• W2592062735 cites W2149855949 @default.
• W2592062735 cites W2222445509 @default.
• W2592062735 cites W2536656830 @default.
• W2592062735 cites W4211113212 @default.
• W2592062735 doi "https://doi.org/10.3389/fmicb.2017.00410" @default.
• W2592062735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5346551" @default.
• W2592062735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28348551" @default.
• W2592062735 hasPublicationYear "2017" @default.
• W2592062735 type Work @default.
• W2592062735 sameAs 2592062735 @default.
• W2592062735 citedByCount "6" @default.
• W2592062735 countsByYear W25920627352017 @default.
• W2592062735 countsByYear W25920627352018 @default.
• W2592062735 countsByYear W25920627352019 @default.
• W2592062735 countsByYear W25920627352022 @default.
• W2592062735 countsByYear W25920627352023 @default.
• W2592062735 crossrefType "journal-article" @default.
• W2592062735 hasAuthorship W2592062735A5001280828 @default.
• W2592062735 hasAuthorship W2592062735A5003155821 @default.
• W2592062735 hasAuthorship W2592062735A5010120453 @default.
• W2592062735 hasAuthorship W2592062735A5015587865 @default.
• W2592062735 hasAuthorship W2592062735A5022274918 @default.
• W2592062735 hasAuthorship W2592062735A5041512038 @default.
• W2592062735 hasAuthorship W2592062735A5044603246 @default.
• W2592062735 hasAuthorship W2592062735A5065544054 @default.
• W2592062735 hasAuthorship W2592062735A5076980836 @default.
• W2592062735 hasBestOaLocation W25920627351 @default.
• W2592062735 hasConcept C104317684 @default.
• W2592062735 hasConcept C141231307 @default.
• W2592062735 hasConcept C142724271 @default.
• W2592062735 hasConcept C144024400 @default.
• W2592062735 hasConcept C149923435 @default.
• W2592062735 hasConcept C159047783 @default.
• W2592062735 hasConcept C193252679 @default.
• W2592062735 hasConcept C2522874641 @default.
• W2592062735 hasConcept C2778750513 @default.
• W2592062735 hasConcept C2779134260 @default.
• W2592062735 hasConcept C2908647359 @default.
• W2592062735 hasConcept C3008058167 @default.
• W2592062735 hasConcept C524204448 @default.
• W2592062735 hasConcept C54355233 @default.
• W2592062735 hasConcept C71924100 @default.
• W2592062735 hasConcept C78458016 @default.
• W2592062735 hasConcept C86803240 @default.
• W2592062735 hasConcept C8769409 @default.
• W2592062735 hasConcept C89623803 @default.
• W2592062735 hasConceptScore W2592062735C104317684 @default.
• W2592062735 hasConceptScore W2592062735C141231307 @default.
• W2592062735 hasConceptScore W2592062735C142724271 @default.
• W2592062735 hasConceptScore W2592062735C144024400 @default.
• W2592062735 hasConceptScore W2592062735C149923435 @default.
• W2592062735 hasConceptScore W2592062735C159047783 @default.
• W2592062735 hasConceptScore W2592062735C193252679 @default.
• W2592062735 hasConceptScore W2592062735C2522874641 @default.
• W2592062735 hasConceptScore W2592062735C2778750513 @default.
• W2592062735 hasConceptScore W2592062735C2779134260 @default.

• next