FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2592079062> ?p ?o ?g. }

• W2592079062 endingPage "15" @default.
• W2592079062 startingPage "1" @default.
• W2592079062 abstract "We have found selective elevation of serum enzyme activities in rats subjected to partial hepatectomy (PH), apparently controlled by hemodynamic flow-bearing physical forces. Here, we assess the involvement of stretch-sensitive calcium channels and calcium mobilization in isolated livers, after chemical modifications of the endothelial glycocalyx and changing perfusion directionality. Inhibiting in vivo protein synthesis, we found that liver enzyme release is influenced by de novo synthesis of endothelial glycocalyx components, and released enzymes are confined into a liver “pool.” Moreover, liver enzyme release depended on extracellular calcium entry possibly mediated by stretch-sensitive calcium channels, and this endothelial-mediated mechanotransduction in liver enzyme release was also evidenced by modifying the glycocalyx carbohydrate components, directionality of perfusing flow rate, and the participation of nitric oxide (NO) and malondialdehyde (MDA), leading to modifications in the intracellular distribution of these enzymes mainly as nuclear enrichment of “mitochondrial” enzymes. In conclusion, the flow-induced shear stress may provide fine-tuned control of released hepatic enzymes through mediation by the endothelium glycocalyx, which provides evidence of a biological role of the enzyme release rather to be merely a biomarker for evaluating hepatotoxicity and liver damage, actually positively influencing progression of liver regeneration in mammals." @default.
• W2592079062 created "2017-03-16" @default.
• W2592079062 creator A5017586770 @default.
• W2592079062 creator A5021737236 @default.
• W2592079062 date "2017-01-01" @default.
• W2592079062 modified "2023-10-17" @default.
• W2592079062 title "Rat Liver Enzyme Release Depends on Blood Flow-Bearing Physical Forces Acting in Endothelium Glycocalyx rather than on Liver Damage" @default.
• W2592079062 cites W1529985581 @default.
• W2592079062 cites W1556155511 @default.
• W2592079062 cites W1899463239 @default.
• W2592079062 cites W1918739547 @default.
• W2592079062 cites W1936770188 @default.
• W2592079062 cites W1957247957 @default.
• W2592079062 cites W1968671910 @default.
• W2592079062 cites W1970199527 @default.
• W2592079062 cites W1971054214 @default.
• W2592079062 cites W1979702382 @default.
• W2592079062 cites W1980751170 @default.
• W2592079062 cites W1997590090 @default.
• W2592079062 cites W1998786337 @default.
• W2592079062 cites W2003673908 @default.
• W2592079062 cites W2010484395 @default.
• W2592079062 cites W2021245198 @default.
• W2592079062 cites W2025190052 @default.
• W2592079062 cites W2027488786 @default.
• W2592079062 cites W2031645309 @default.
• W2592079062 cites W2034248554 @default.
• W2592079062 cites W2034706816 @default.
• W2592079062 cites W2036145275 @default.
• W2592079062 cites W2040536713 @default.
• W2592079062 cites W2040917386 @default.
• W2592079062 cites W2041214653 @default.
• W2592079062 cites W2045794496 @default.
• W2592079062 cites W2048915475 @default.
• W2592079062 cites W2052400143 @default.
• W2592079062 cites W2054635074 @default.
• W2592079062 cites W2055743016 @default.
• W2592079062 cites W2058258523 @default.
• W2592079062 cites W2059765122 @default.
• W2592079062 cites W2063419955 @default.
• W2592079062 cites W2066099322 @default.
• W2592079062 cites W2069476395 @default.
• W2592079062 cites W2077495956 @default.
• W2592079062 cites W2078233149 @default.
• W2592079062 cites W2078403542 @default.
• W2592079062 cites W2083517980 @default.
• W2592079062 cites W2084241306 @default.
• W2592079062 cites W2090872850 @default.
• W2592079062 cites W2098274894 @default.
• W2592079062 cites W2101786726 @default.
• W2592079062 cites W2107137340 @default.
• W2592079062 cites W2110223847 @default.
• W2592079062 cites W2114080768 @default.
• W2592079062 cites W2128478402 @default.
• W2592079062 cites W2128792860 @default.
• W2592079062 cites W2133545678 @default.
• W2592079062 cites W2136449524 @default.
• W2592079062 cites W2147381285 @default.
• W2592079062 cites W2147857868 @default.
• W2592079062 cites W2150214660 @default.
• W2592079062 cites W2152252241 @default.
• W2592079062 cites W2163762564 @default.
• W2592079062 cites W2164527564 @default.
• W2592079062 cites W2167391679 @default.
• W2592079062 cites W2178956145 @default.
• W2592079062 cites W2362543173 @default.
• W2592079062 cites W2409391673 @default.
• W2592079062 cites W2519494357 @default.
• W2592079062 cites W257292438 @default.
• W2592079062 cites W4232731758 @default.
• W2592079062 doi "https://doi.org/10.1155/2017/1360565" @default.
• W2592079062 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5350326" @default.
• W2592079062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28337244" @default.
• W2592079062 hasPublicationYear "2017" @default.
• W2592079062 type Work @default.
• W2592079062 sameAs 2592079062 @default.
• W2592079062 citedByCount "8" @default.
• W2592079062 countsByYear W25920790622018 @default.
• W2592079062 countsByYear W25920790622020 @default.
• W2592079062 countsByYear W25920790622021 @default.
• W2592079062 countsByYear W25920790622022 @default.
• W2592079062 countsByYear W25920790622023 @default.
• W2592079062 crossrefType "journal-article" @default.
• W2592079062 hasAuthorship W2592079062A5017586770 @default.
• W2592079062 hasAuthorship W2592079062A5021737236 @default.
• W2592079062 hasBestOaLocation W25920790621 @default.
• W2592079062 hasConcept C12554922 @default.
• W2592079062 hasConcept C134018914 @default.
• W2592079062 hasConcept C178790620 @default.
• W2592079062 hasConcept C181104049 @default.
• W2592079062 hasConcept C181199279 @default.
• W2592079062 hasConcept C185592680 @default.
• W2592079062 hasConcept C2776992346 @default.
• W2592079062 hasConcept C2780098789 @default.
• W2592079062 hasConcept C28406088 @default.
• W2592079062 hasConcept C519063684 @default.
• W2592079062 hasConcept C519581460 @default.
• W2592079062 hasConcept C55493867 @default.

• next