FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2592132295> ?p ?o ?g. }

• W2592132295 endingPage "1048" @default.
• W2592132295 startingPage "1040" @default.
• W2592132295 abstract "Gadolinium-based-contrast-agents (GBCAs) are used for magnetic-resonance-imaging and associated with renal and cardiovascular adverse reactions caused by released Gd3+ ions. Gd3+ is also a modulator of mechano-gated ion channels, including the epithelial Na+ channel (ENaC) that is expressed in kidney epithelium and the vasculature. ENaC is important for salt-/water homeostasis and blood pressure regulation and a likely target of released Gd3+ from GBCAs causing the above-mentioned adverse reactions. Therefore this study examined the effect of Gd3+ and GBCAs on ENaC's activity.Human αβγENaC was expressed in Xenopus laevis oocytes and exposed to Gd3+, linear (Gd-DTPA, Magnevist) or cyclic (Dotarem) GBCAs. Transmembrane ion-currents (IM) were recorded by the two-electrode-voltage-clamp technique and Gd3+-release by Gd-DTPA was confirmed by inductively coupled plasma-mass spectrometry.Gd3+ exerts biphasic effects on ENaC's activity: ≤0.3mmol/l decreased IM which was preventable by DEPC (modifies histidines). Strikingly Gd3+≥0.4mmol/l increased IM and this effect was prevented by cysteine-modifying MTSEA. Linear Gd-DTPA and Magnevist mimicked the effect of ≤0.3mmol/l Gd3+, whereas the chelator DTPA showed no effect. Gd3+ and Gd-DTPA increased the IC50 for amiloride, but did not affect ENaC's self-inhibition. Interestingly, cyclic Gd-DOTA (Dotarem) increased IM to a similar extent as its chelator DOTA, suggesting that the chelator rather than released Gd3+ is responsible for this effect.These results confirm Gd3+-release from linear Gd-DTPA and indicate that the released Gd3+ amount is sufficient to interfere with ENaC's activity to provide putative explanations for GBCA-related adverse effects." @default.
• W2592132295 created "2017-03-16" @default.
• W2592132295 creator A5050871548 @default.
• W2592132295 creator A5058061466 @default.
• W2592132295 creator A5068850675 @default.
• W2592132295 date "2017-05-01" @default.
• W2592132295 modified "2023-09-26" @default.
• W2592132295 title "Gadolinium released by the linear gadolinium-based contrast-agent Gd-DTPA decreases the activity of human epithelial Na + channels (ENaCs)" @default.
• W2592132295 cites W1567934730 @default.
• W2592132295 cites W1963764260 @default.
• W2592132295 cites W1966258987 @default.
• W2592132295 cites W1966571419 @default.
• W2592132295 cites W1981903107 @default.
• W2592132295 cites W1985305470 @default.
• W2592132295 cites W1995071576 @default.
• W2592132295 cites W1995332367 @default.
• W2592132295 cites W2004404685 @default.
• W2592132295 cites W2015842349 @default.
• W2592132295 cites W2021285469 @default.
• W2592132295 cites W2021407435 @default.
• W2592132295 cites W2022437128 @default.
• W2592132295 cites W2029236231 @default.
• W2592132295 cites W2034093166 @default.
• W2592132295 cites W2040099348 @default.
• W2592132295 cites W2049899870 @default.
• W2592132295 cites W2054917280 @default.
• W2592132295 cites W2054966786 @default.
• W2592132295 cites W2057068296 @default.
• W2592132295 cites W2058804065 @default.
• W2592132295 cites W2059116113 @default.
• W2592132295 cites W2060437861 @default.
• W2592132295 cites W2066463729 @default.
• W2592132295 cites W2066801370 @default.
• W2592132295 cites W2068921266 @default.
• W2592132295 cites W2071007358 @default.
• W2592132295 cites W2071197287 @default.
• W2592132295 cites W2071201135 @default.
• W2592132295 cites W2073236176 @default.
• W2592132295 cites W2074913671 @default.
• W2592132295 cites W2075390536 @default.
• W2592132295 cites W2080235186 @default.
• W2592132295 cites W2099258590 @default.
• W2592132295 cites W2104404316 @default.
• W2592132295 cites W2108281282 @default.
• W2592132295 cites W2116878814 @default.
• W2592132295 cites W2120245762 @default.
• W2592132295 cites W2129762317 @default.
• W2592132295 cites W2129768655 @default.
• W2592132295 cites W2140057866 @default.
• W2592132295 cites W2140853270 @default.
• W2592132295 cites W2143751651 @default.
• W2592132295 cites W2145961680 @default.
• W2592132295 cites W2150489367 @default.
• W2592132295 cites W2158241519 @default.
• W2592132295 cites W2159550270 @default.
• W2592132295 cites W2160796771 @default.
• W2592132295 cites W2170294491 @default.
• W2592132295 cites W2172109574 @default.
• W2592132295 cites W2184212489 @default.
• W2592132295 cites W2192100681 @default.
• W2592132295 cites W2251858503 @default.
• W2592132295 cites W2324561117 @default.
• W2592132295 doi "https://doi.org/10.1016/j.bbamem.2017.02.019" @default.
• W2592132295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28257815" @default.
• W2592132295 hasPublicationYear "2017" @default.
• W2592132295 type Work @default.
• W2592132295 sameAs 2592132295 @default.
• W2592132295 citedByCount "4" @default.
• W2592132295 countsByYear W25921322952018 @default.
• W2592132295 countsByYear W25921322952019 @default.
• W2592132295 countsByYear W25921322952021 @default.
• W2592132295 crossrefType "journal-article" @default.
• W2592132295 hasAuthorship W2592132295A5050871548 @default.
• W2592132295 hasAuthorship W2592132295A5058061466 @default.
• W2592132295 hasAuthorship W2592132295A5068850675 @default.
• W2592132295 hasBestOaLocation W25921322951 @default.
• W2592132295 hasConcept C104317684 @default.
• W2592132295 hasConcept C12554922 @default.
• W2592132295 hasConcept C178790620 @default.
• W2592132295 hasConcept C185592680 @default.
• W2592132295 hasConcept C197404232 @default.
• W2592132295 hasConcept C2779535977 @default.
• W2592132295 hasConcept C2779608910 @default.
• W2592132295 hasConcept C537181965 @default.
• W2592132295 hasConcept C55493867 @default.
• W2592132295 hasConcept C557651011 @default.
• W2592132295 hasConcept C6507245 @default.
• W2592132295 hasConcept C86803240 @default.
• W2592132295 hasConceptScore W2592132295C104317684 @default.
• W2592132295 hasConceptScore W2592132295C12554922 @default.
• W2592132295 hasConceptScore W2592132295C178790620 @default.
• W2592132295 hasConceptScore W2592132295C185592680 @default.
• W2592132295 hasConceptScore W2592132295C197404232 @default.
• W2592132295 hasConceptScore W2592132295C2779535977 @default.
• W2592132295 hasConceptScore W2592132295C2779608910 @default.
• W2592132295 hasConceptScore W2592132295C537181965 @default.
• W2592132295 hasConceptScore W2592132295C55493867 @default.
• W2592132295 hasConceptScore W2592132295C557651011 @default.

• next