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• W2592165738 startingPage "1161" @default.
• W2592165738 abstract "A new conceptual nanoparticle consisting of a silica-coated iron oxide magnetic core and a fattigation-based biocompatible shell with oleic acid and hydrophilic protein (gelatin). The prepared particle can be a useful theranostics platform material for diagnostic imaging and as a drug delivery system. Oleic acid and gelatin were conjugated on the silica-coated magnetic nanoparticle surface to provide three primary functionalities: 1) enhancing biocompatibility and solubility in aqueous solution and providing the ability to incorporate hydrophobic chemical drugs into the shell for delivery, 2) improving treatment-response magnetic monitoring as a diagnostic agent with low nanotoxicity, and 3) increasing anticancer efficacy owing to the controlled release of the incorporated drug in cells and in an animal model. We prepared magnetic-silica nanoparticles with super-paramagnetic properties, which are utilized as a T2-weighted magnetic resonance imaging agent. After formation of an oleic acid-gelatin shell, the prepared materials exhibited high loading capacity for a hydrophobic anticancer drug (paclitaxel). Our particle platform system exhibited higher therapeutic efficacy and lower toxicological effects in vitro and in an in vivo cancer model than a clinically available chemo-drug (Taxol®). Our findings strongly suggest that this nanoparticle system can serve as a platform for cancer therapy by the incorporation of chemical drugs." @default.
• W2592165738 created "2017-03-16" @default.
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• W2592165738 date "2017-06-01" @default.
• W2592165738 modified "2023-10-02" @default.
• W2592165738 title "Fattigation-platform theranostic nanoparticles for cancer therapy" @default.
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• W2592165738 doi "https://doi.org/10.1016/j.msec.2017.03.012" @default.
• W2592165738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28415402" @default.
• W2592165738 hasPublicationYear "2017" @default.
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