Matches in SemOpenAlex for { <https://semopenalex.org/work/W2592222428> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2592222428 abstract "Objectives: The objectives of this study were to use the heterogeneity of the patient-derived xenograft (PDX) model to characterize the surviving population for de novo mediators of chemotherapy resistance, and subsequently target pathways contributing to that resistance. Methods: Tumors removed during primary tumor-reductive surgery were implanted directly into SCID mice, either subcutaneously and intraperitoneally. Mice with PDX tumors were treated with combination carboplatin/paclitaxel for 4 weeks. In addition, chemoresistant models were developed by treatment until complete response was achieved, and recurrent tumors retreated until resistant. Patient tumors, developing PDX tumors, and post-chemo surviving residual tumors were subjected to qPCR arrays, RNA-Seq, Methyl-Seq, and proteomic analysis; and IHC for Ki-67 and cancer stem cell markers CD133, ALDH1, and CD44. The Pol-I inhibitor CX-5461 was used to treat five PDX models. Results: At the mRNA level, the original patient tumors were similar to PDX tumors in mice as assessed by an 84-oncogene expression panel. Subcutaneous and intraperitoneal tumors were also remarkably similar. Patient responses correlated well with responses in mice. Proteomic analysis identified 14,023 unique proteins, of which approximately 30% were murine, and 70% were human in each sample. A total of 1,202 of human proteins were found to be differently expressed (p-value Conclusion: The ovarian-PDX model exhibits consistent molecular and biologic similarity to patient tumors. Post-chemo tumors reveal multiple pathways to be consistently altered. Taking this information back to the PDX model demonstrated that inhibition of ribosomal RNA synthesis was highly effective, offering a novel opportunity to preferentially target the chemoresistant population in ovarian cancer. Citation Format: Zachary Dobbin, Robert Cornelison, Ashwini K. Katre, David A. Schneider, Karen Watters, Fabian Coscia, Ernst Lengyel, Aaron Buechlein, Fang Fang, Kenneth Nephew, Charles N. Landen, Jr.. Identification and targeting mediators of chemoresistance using the patient-derived xenograft model of ovarian cancer. [abstract]. In: Proceedings of the AACR Special Conference: Patient-Derived Cancer Models: Present and Future Applications from Basic Science to the Clinic; Feb 11-14, 2016; New Orleans, LA. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(16_Suppl):Abstract nr B39." @default.
- W2592222428 created "2017-03-16" @default.
- W2592222428 creator A5018891733 @default.
- W2592222428 creator A5019142318 @default.
- W2592222428 creator A5024265298 @default.
- W2592222428 creator A5027620152 @default.
- W2592222428 creator A5029131894 @default.
- W2592222428 creator A5043490198 @default.
- W2592222428 creator A5052302109 @default.
- W2592222428 creator A5055503557 @default.
- W2592222428 creator A5061888144 @default.
- W2592222428 creator A5089403507 @default.
- W2592222428 creator A5090387172 @default.
- W2592222428 date "2016-08-14" @default.
- W2592222428 modified "2023-09-26" @default.
- W2592222428 title "Abstract B39: Identification and targeting mediators of chemoresistance using the patient-derived xenograft model of ovarian cancer" @default.
- W2592222428 doi "https://doi.org/10.1158/1557-3265.pdx16-b39" @default.
- W2592222428 hasPublicationYear "2016" @default.
- W2592222428 type Work @default.
- W2592222428 sameAs 2592222428 @default.
- W2592222428 citedByCount "0" @default.
- W2592222428 crossrefType "proceedings-article" @default.
- W2592222428 hasAuthorship W2592222428A5018891733 @default.
- W2592222428 hasAuthorship W2592222428A5019142318 @default.
- W2592222428 hasAuthorship W2592222428A5024265298 @default.
- W2592222428 hasAuthorship W2592222428A5027620152 @default.
- W2592222428 hasAuthorship W2592222428A5029131894 @default.
- W2592222428 hasAuthorship W2592222428A5043490198 @default.
- W2592222428 hasAuthorship W2592222428A5052302109 @default.
- W2592222428 hasAuthorship W2592222428A5055503557 @default.
- W2592222428 hasAuthorship W2592222428A5061888144 @default.
- W2592222428 hasAuthorship W2592222428A5089403507 @default.
- W2592222428 hasAuthorship W2592222428A5090387172 @default.
- W2592222428 hasConcept C121608353 @default.
- W2592222428 hasConcept C126322002 @default.
- W2592222428 hasConcept C1491633281 @default.
- W2592222428 hasConcept C2776694085 @default.
- W2592222428 hasConcept C2777292972 @default.
- W2592222428 hasConcept C2778239845 @default.
- W2592222428 hasConcept C2780427987 @default.
- W2592222428 hasConcept C2780932548 @default.
- W2592222428 hasConcept C2781018059 @default.
- W2592222428 hasConcept C2781451048 @default.
- W2592222428 hasConcept C2908647359 @default.
- W2592222428 hasConcept C29537977 @default.
- W2592222428 hasConcept C502942594 @default.
- W2592222428 hasConcept C54355233 @default.
- W2592222428 hasConcept C71924100 @default.
- W2592222428 hasConcept C86803240 @default.
- W2592222428 hasConcept C99454951 @default.
- W2592222428 hasConceptScore W2592222428C121608353 @default.
- W2592222428 hasConceptScore W2592222428C126322002 @default.
- W2592222428 hasConceptScore W2592222428C1491633281 @default.
- W2592222428 hasConceptScore W2592222428C2776694085 @default.
- W2592222428 hasConceptScore W2592222428C2777292972 @default.
- W2592222428 hasConceptScore W2592222428C2778239845 @default.
- W2592222428 hasConceptScore W2592222428C2780427987 @default.
- W2592222428 hasConceptScore W2592222428C2780932548 @default.
- W2592222428 hasConceptScore W2592222428C2781018059 @default.
- W2592222428 hasConceptScore W2592222428C2781451048 @default.
- W2592222428 hasConceptScore W2592222428C2908647359 @default.
- W2592222428 hasConceptScore W2592222428C29537977 @default.
- W2592222428 hasConceptScore W2592222428C502942594 @default.
- W2592222428 hasConceptScore W2592222428C54355233 @default.
- W2592222428 hasConceptScore W2592222428C71924100 @default.
- W2592222428 hasConceptScore W2592222428C86803240 @default.
- W2592222428 hasConceptScore W2592222428C99454951 @default.
- W2592222428 hasLocation W25922224281 @default.
- W2592222428 hasOpenAccess W2592222428 @default.
- W2592222428 hasPrimaryLocation W25922224281 @default.
- W2592222428 hasRelatedWork W1966006491 @default.
- W2592222428 hasRelatedWork W2006769811 @default.
- W2592222428 hasRelatedWork W2035827057 @default.
- W2592222428 hasRelatedWork W2087836455 @default.
- W2592222428 hasRelatedWork W2088679011 @default.
- W2592222428 hasRelatedWork W2129909745 @default.
- W2592222428 hasRelatedWork W2331543161 @default.
- W2592222428 hasRelatedWork W2484891052 @default.
- W2592222428 hasRelatedWork W2497482395 @default.
- W2592222428 hasRelatedWork W2565914818 @default.
- W2592222428 hasRelatedWork W2592123220 @default.
- W2592222428 hasRelatedWork W2594108931 @default.
- W2592222428 hasRelatedWork W2740250787 @default.
- W2592222428 hasRelatedWork W2887020889 @default.
- W2592222428 hasRelatedWork W2887166320 @default.
- W2592222428 hasRelatedWork W2887569362 @default.
- W2592222428 hasRelatedWork W2944200496 @default.
- W2592222428 hasRelatedWork W2953649256 @default.
- W2592222428 hasRelatedWork W3034612993 @default.
- W2592222428 hasRelatedWork W3083534491 @default.
- W2592222428 isParatext "false" @default.
- W2592222428 isRetracted "false" @default.
- W2592222428 magId "2592222428" @default.
- W2592222428 workType "article" @default.