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- W2592312290 abstract "Significance At the microscopic scale, collective behaviors of motile units can induce directed fluid flow on a larger length scale than individual units based on their hydrodynamic interactions. Here, we found that the motor-driven extensile behaviors of microtubule bundles in the cytoplasm induce rotational flow in a cell-sized confined space on length scale and timescale that were 10- to 100-fold longer than the vortex flows emerging in the bulk space. These scale differences were derived from mechanical force generation by microtubule bundle elongation near the physical boundary and the transmission of this force over the microtubule network. These findings suggest that the microtubule cytoskeleton utilizes not only hydrodynamic interactions but also mechanical interactions to induce large-scale cytoplasmic flow." @default.
- W2592312290 created "2017-03-16" @default.
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- W2592312290 date "2017-03-06" @default.
- W2592312290 modified "2023-10-13" @default.
- W2592312290 title "Spatial confinement of active microtubule networks induces large-scale rotational cytoplasmic flow" @default.
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- W2592312290 doi "https://doi.org/10.1073/pnas.1616001114" @default.
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