FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2592339885> ?p ?o ?g. }

• W2592339885 abstract "ABSTRACT Critically ill patients frequently have substantially altered pharmacokinetics compared to non-critically ill patients. We investigated the impact of pharmacokinetic alterations on bacterial killing and resistance for commonly used meropenem dosing regimens. A Pseudomonas aeruginosa isolate (MIC meropenem 0.25 mg/liter) was studied in the hollow-fiber infection model (inoculum ∼10 7.5 CFU/ml; 10 days). Pharmacokinetic profiles representing critically ill patients with augmented renal clearance (ARC), normal, or impaired renal function (creatinine clearances of 285, 120, or ∼10 ml/min, respectively) were generated for three meropenem regimens (2, 1, and 0.5 g administered as 8-hourly 30-min infusions), plus 1 g given 12 hourly with impaired renal function. The time course of total and less-susceptible populations and MICs were determined. Mechanism-based modeling (MBM) was performed using S-ADAPT. All dosing regimens across all renal functions produced similar initial bacterial killing (≤∼2.5 log 10 ). For all regimens subjected to ARC, regrowth occurred after 7 h. For normal and impaired renal function, bacterial killing continued until 23 to 47 h; regrowth then occurred with 0.5- and 1-g regimens with normal renal function ( fT >5×MIC = 56 and 69%, fC min /MIC < 2); the emergence of less-susceptible populations (≥32-fold increases in MIC) accompanied all regrowth. Bacterial counts remained suppressed across 10 days with normal (2-g 8-hourly regimen) and impaired (all regimens) renal function ( fT >5×MIC ≥ 82%, fC min /MIC ≥ 2). The MBM successfully described bacterial killing and regrowth for all renal functions and regimens simultaneously. Optimized dosing regimens, including extended infusions and/or combinations, supported by MBM and Monte Carlo simulations, should be evaluated in the context of ARC to maximize bacterial killing and suppress resistance emergence." @default.
• W2592339885 created "2017-03-16" @default.
• W2592339885 creator A5015076483 @default.
• W2592339885 creator A5030691636 @default.
• W2592339885 creator A5037468542 @default.
• W2592339885 creator A5042046351 @default.
• W2592339885 creator A5046635592 @default.
• W2592339885 creator A5048000157 @default.
• W2592339885 creator A5058674939 @default.
• W2592339885 creator A5066789024 @default.
• W2592339885 creator A5073046394 @default.
• W2592339885 creator A5080585779 @default.
• W2592339885 creator A5089733754 @default.
• W2592339885 date "2017-05-01" @default.
• W2592339885 modified "2023-10-17" @default.
• W2592339885 title "Substantial Impact of Altered Pharmacokinetics in Critically Ill Patients on the Antibacterial Effects of Meropenem Evaluated via the Dynamic Hollow-Fiber Infection Model" @default.
• W2592339885 cites W1920534944 @default.
• W2592339885 cites W1933654092 @default.
• W2592339885 cites W1942249667 @default.
• W2592339885 cites W1966483053 @default.
• W2592339885 cites W1968252808 @default.
• W2592339885 cites W1975361143 @default.
• W2592339885 cites W1978397220 @default.
• W2592339885 cites W1980196020 @default.
• W2592339885 cites W1981568603 @default.
• W2592339885 cites W1981898530 @default.
• W2592339885 cites W1986375294 @default.
• W2592339885 cites W1993397663 @default.
• W2592339885 cites W2009720606 @default.
• W2592339885 cites W2016348965 @default.
• W2592339885 cites W2020459071 @default.
• W2592339885 cites W2027169933 @default.
• W2592339885 cites W2033990028 @default.
• W2592339885 cites W2044526347 @default.
• W2592339885 cites W2050947530 @default.
• W2592339885 cites W2057226149 @default.
• W2592339885 cites W2058213101 @default.
• W2592339885 cites W2058562206 @default.
• W2592339885 cites W2060169066 @default.
• W2592339885 cites W2070828665 @default.
• W2592339885 cites W2073122282 @default.
• W2592339885 cites W2075287054 @default.
• W2592339885 cites W2076363688 @default.
• W2592339885 cites W2079691262 @default.
• W2592339885 cites W2081686578 @default.
• W2592339885 cites W2085150747 @default.
• W2592339885 cites W2094476444 @default.
• W2592339885 cites W2100292802 @default.
• W2592339885 cites W2101416655 @default.
• W2592339885 cites W2103137511 @default.
• W2592339885 cites W2105898693 @default.
• W2592339885 cites W2106359046 @default.
• W2592339885 cites W2108791617 @default.
• W2592339885 cites W2113717321 @default.
• W2592339885 cites W2115539291 @default.
• W2592339885 cites W2117506315 @default.
• W2592339885 cites W2123435197 @default.
• W2592339885 cites W2125528224 @default.
• W2592339885 cites W2127863743 @default.
• W2592339885 cites W2133916602 @default.
• W2592339885 cites W2135190942 @default.
• W2592339885 cites W2136706836 @default.
• W2592339885 cites W2137435784 @default.
• W2592339885 cites W2142365884 @default.
• W2592339885 cites W2143024482 @default.
• W2592339885 cites W2143682782 @default.
• W2592339885 cites W2145541037 @default.
• W2592339885 cites W2148706534 @default.
• W2592339885 cites W2149974939 @default.
• W2592339885 cites W2153641174 @default.
• W2592339885 cites W2156208059 @default.
• W2592339885 cites W2161442738 @default.
• W2592339885 cites W2165158988 @default.
• W2592339885 cites W2165839757 @default.
• W2592339885 cites W2170187421 @default.
• W2592339885 cites W2408088108 @default.
• W2592339885 cites W2515285744 @default.
• W2592339885 cites W2518755369 @default.
• W2592339885 cites W2551981896 @default.
• W2592339885 doi "https://doi.org/10.1128/aac.02642-16" @default.
• W2592339885 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5404522" @default.
• W2592339885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28264846" @default.
• W2592339885 hasPublicationYear "2017" @default.
• W2592339885 type Work @default.
• W2592339885 sameAs 2592339885 @default.
• W2592339885 citedByCount "32" @default.
• W2592339885 countsByYear W25923398852017 @default.
• W2592339885 countsByYear W25923398852018 @default.
• W2592339885 countsByYear W25923398852019 @default.
• W2592339885 countsByYear W25923398852020 @default.
• W2592339885 countsByYear W25923398852021 @default.
• W2592339885 countsByYear W25923398852022 @default.
• W2592339885 countsByYear W25923398852023 @default.
• W2592339885 crossrefType "journal-article" @default.
• W2592339885 hasAuthorship W2592339885A5015076483 @default.
• W2592339885 hasAuthorship W2592339885A5030691636 @default.
• W2592339885 hasAuthorship W2592339885A5037468542 @default.
• W2592339885 hasAuthorship W2592339885A5042046351 @default.
• W2592339885 hasAuthorship W2592339885A5046635592 @default.
• W2592339885 hasAuthorship W2592339885A5048000157 @default.

• next