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- W2592353487 abstract "Outer membrane protein A (OmpA) is the most promising vaccine candidate against one of the most successful nosocomial pathogens, A. baumannii. Despite advantages of the antigen, its cytotoxicity could be considered as a challenge in clinical trials. In order to improve this effective immunogen, rational vaccine design strategies such as structure-based vaccinology should be assessed. However, native structure of OmpA remains controversial. The present study is conducted to address the native structure of OmpA; then, a novel immunogen with lower toxicity and higher antigenicity was designed based on structural vaccinology. Various bioinformatic and immunoinformatic tools were harnessed to perform analyses such as topology, secondary structure, and tertiary structure predictions as well as B-cell epitope predictions. A novel 12-stranded model is suggested for OmpA. K320 and K322 were substituted by Alanine, NADEEFWN sequence was replaced by YKYDFDGVNRGTRGTSEEGTL, Position 1-24 at the N-terminus and the C-terminal sequence VVQPGQEAAAPAAAQ were removed. The designed construct has more epitope density and antigenic properties with higher immunogenicity while its cytotoxicity is decreased. Moreover, this single cross-protective antigen could trigger antibodies rendering protection against two important nosocomial pathogens i.e. Pseudomonas aeruginosa and A. baumannii." @default.
- W2592353487 created "2017-03-16" @default.
- W2592353487 creator A5015122908 @default.
- W2592353487 creator A5047638005 @default.
- W2592353487 creator A5050241462 @default.
- W2592353487 creator A5057596333 @default.
- W2592353487 creator A5065746360 @default.
- W2592353487 date "2017-04-01" @default.
- W2592353487 modified "2023-09-29" @default.
- W2592353487 title "In silico design of an immunogen against Acinetobacter baumannii based on a novel model for native structure of Outer membrane protein A" @default.
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- W2592353487 doi "https://doi.org/10.1016/j.micpath.2017.02.028" @default.
- W2592353487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28242426" @default.
- W2592353487 hasPublicationYear "2017" @default.
- W2592353487 type Work @default.