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• W2592381569 abstract "Alphaviruses are medically important mosquito-borne viruses that cause a range of diseases in humans from febrile illness to arthritis or encephalitis. The innate immune response functions to suppress virus replication through upregulation of antiviral molecules and contributes to development of the adaptive immune response. Myeloid cells act as master regulators of virus infection by initiating both the innate and adaptive immune responses. Alphaviruses are capable of antagonizing individual components of these responses to increase replicative fitness in vivo. However, recently, studies have demonstrated that some alphaviruses avoid myeloid cell replication altogether to achieve a similar effect. In this review, we summarize how alphaviruses evade myeloid cell infection and individual inductive mechanisms, thereby limiting the activation of the innate immune response." @default.
• W2592381569 created "2017-03-16" @default.
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• W2592381569 date "2017-04-01" @default.
• W2592381569 modified "2023-10-18" @default.
• W2592381569 title "Alphaviruses suppress host immunity by preventing myeloid cell replication and antagonizing innate immune responses" @default.
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• W2592381569 doi "https://doi.org/10.1016/j.coviro.2017.02.004" @default.
• W2592381569 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5823529" @default.
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