FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2592381610> ?p ?o ?g. }

• W2592381610 endingPage "232" @default.
• W2592381610 startingPage "197" @default.
• W2592381610 abstract "The human brain requires uninterrupted delivery of blood-borne oxygen and nutrients to sustain its function. Focal ischemia, particularly, ischemic stroke, and global ischemia imposed by cardiac arrest disrupt the brain's fuel supply. The resultant ATP depletion initiates a complex injury cascade encompassing intracellular Ca2+ overload, glutamate excitotoxicity, oxido-nitrosative stress, extracellular matrix degradation, and inflammation, culminating in neuronal and astroglial necrosis and apoptosis, neurocognitive deficits, and even death. Unfortunately, brain ischemia has proven refractory to pharmacological intervention. Many promising treatments afforded brain protection in animal models of focal and global ischemia, but failed to improve survival and neurocognitive recovery of stroke and cardiac arrest patients in randomized clinical trials. The culprits are the blood-brain barrier (BBB) that limits transferral of medications to the brain parenchyma, and the sheer complexity of the injury cascade, which presents a daunting array of targets unlikely to respond to monotherapies. Erythropoietin is a powerful neuroprotectant capable of interrupting multiple aspects of the brain injury cascade. Preclinical research demonstrates erythropoietin's ability to suppress glutamate excitotoxicity and intracellular Ca2+ overload, dampen oxidative stress and inflammation, interrupt the apoptotic cascade, and preserve BBB integrity. However, the erythropoietin dosages required to traverse the BBB and achieve therapeutically effective concentrations in the brain parenchyma impose untoward side effects. Recent discoveries that hypoxia induces erythropoietin production within the brain and that neurons, astroglia, and cerebrovascular endothelium harbor membrane erythropoietin receptors, raise the exciting prospect of harnessing endogenous erythropoietin to protect the brain from the ravages of ischemia-reperfusion." @default.
• W2592381610 created "2017-03-16" @default.
• W2592381610 creator A5007860884 @default.
• W2592381610 creator A5015000973 @default.
• W2592381610 date "2017-01-01" @default.
• W2592381610 modified "2023-09-23" @default.
• W2592381610 title "Erythropoietin: Endogenous Protection of Ischemic Brain" @default.
• W2592381610 cites W126490209 @default.
• W2592381610 cites W1484618897 @default.
• W2592381610 cites W1498420568 @default.
• W2592381610 cites W1504583940 @default.
• W2592381610 cites W1509127316 @default.
• W2592381610 cites W1516113840 @default.
• W2592381610 cites W1524857210 @default.
• W2592381610 cites W1538983550 @default.
• W2592381610 cites W1821918060 @default.
• W2592381610 cites W1853393224 @default.
• W2592381610 cites W1881066497 @default.
• W2592381610 cites W1951772246 @default.
• W2592381610 cites W1961885071 @default.
• W2592381610 cites W1963855396 @default.
• W2592381610 cites W1965597112 @default.
• W2592381610 cites W1966698297 @default.
• W2592381610 cites W1968254955 @default.
• W2592381610 cites W1969099509 @default.
• W2592381610 cites W1969824218 @default.
• W2592381610 cites W1970222831 @default.
• W2592381610 cites W1970325360 @default.
• W2592381610 cites W1971290269 @default.
• W2592381610 cites W1971967768 @default.
• W2592381610 cites W1973342484 @default.
• W2592381610 cites W1973802999 @default.
• W2592381610 cites W1974811729 @default.
• W2592381610 cites W1974898218 @default.
• W2592381610 cites W1975857526 @default.
• W2592381610 cites W1976210749 @default.
• W2592381610 cites W1976422798 @default.
• W2592381610 cites W1977731043 @default.
• W2592381610 cites W1977833857 @default.
• W2592381610 cites W1978726693 @default.
• W2592381610 cites W1984555524 @default.
• W2592381610 cites W1985960200 @default.
• W2592381610 cites W1987178854 @default.
• W2592381610 cites W1987603059 @default.
• W2592381610 cites W1988983923 @default.
• W2592381610 cites W1989229171 @default.
• W2592381610 cites W1990909879 @default.
• W2592381610 cites W1992967957 @default.
• W2592381610 cites W1995305184 @default.
• W2592381610 cites W1996993676 @default.
• W2592381610 cites W1997652091 @default.
• W2592381610 cites W1997867310 @default.
• W2592381610 cites W1997966386 @default.
• W2592381610 cites W1999159638 @default.
• W2592381610 cites W2004122699 @default.
• W2592381610 cites W2005538515 @default.
• W2592381610 cites W2006084919 @default.
• W2592381610 cites W2006580595 @default.
• W2592381610 cites W2009457069 @default.
• W2592381610 cites W2010345778 @default.
• W2592381610 cites W2012154384 @default.
• W2592381610 cites W2014033528 @default.
• W2592381610 cites W2014892027 @default.
• W2592381610 cites W2015171564 @default.
• W2592381610 cites W2016124510 @default.
• W2592381610 cites W2016350888 @default.
• W2592381610 cites W2016355218 @default.
• W2592381610 cites W2016381698 @default.
• W2592381610 cites W2016451375 @default.
• W2592381610 cites W2016656903 @default.
• W2592381610 cites W2018409191 @default.
• W2592381610 cites W2019104466 @default.
• W2592381610 cites W2020189193 @default.
• W2592381610 cites W2022123825 @default.
• W2592381610 cites W2023169605 @default.
• W2592381610 cites W2024496002 @default.
• W2592381610 cites W2025960909 @default.
• W2592381610 cites W2028861484 @default.
• W2592381610 cites W2029011122 @default.
• W2592381610 cites W2030603527 @default.
• W2592381610 cites W2032926631 @default.
• W2592381610 cites W2033761616 @default.
• W2592381610 cites W2034682648 @default.
• W2592381610 cites W2036622571 @default.
• W2592381610 cites W2037096227 @default.
• W2592381610 cites W2037707112 @default.
• W2592381610 cites W2037714880 @default.
• W2592381610 cites W2039128946 @default.
• W2592381610 cites W2039933991 @default.
• W2592381610 cites W2041206321 @default.
• W2592381610 cites W2045757823 @default.
• W2592381610 cites W2047793512 @default.
• W2592381610 cites W2047854832 @default.
• W2592381610 cites W2047887920 @default.
• W2592381610 cites W2050856345 @default.
• W2592381610 cites W2053442326 @default.
• W2592381610 cites W2058310010 @default.
• W2592381610 cites W2058316500 @default.

• next