Matches in SemOpenAlex for { <https://semopenalex.org/work/W2592393384> ?p ?o ?g. }
- W2592393384 endingPage "e0173056" @default.
- W2592393384 startingPage "e0173056" @default.
- W2592393384 abstract "It has been well established that many vaccinia virus proteins suppress host antiviral pathways by targeting the transcription of antiviral proteins, thus evading the host innate immune system. However, whether viral proteins have an effect on the host’s overall cellular transcription is less understood. In this study we investigated the regulation of heterochromatin during vaccinia virus infection. Heterochromatin is a highly condensed form of chromatin that is less transcriptionally active and characterized by methylation of histone proteins. We examined the change in methylation of two histone proteins, H3 and H4, which are major markers of heterochromatin, during the course of viral infection. Using immunofluorescence microscopy and flow cytometry we were able to track the overall change in the methylated levels of H3K9 and H4K20. Our results suggest that there is significant increase in methylation of H3K9 and H4K20 during Orthopoxviruses infection compared to mock-infected cells. However, this effect was not seen when we infected cells with Leporipoxviruses. We further screened several vaccinia virus single and multi-gene deletion mutant and identified the vaccinia virus gene K7R as a contributor to the increase in cellular histone methylation during infection." @default.
- W2592393384 created "2017-03-16" @default.
- W2592393384 creator A5002815191 @default.
- W2592393384 creator A5007171012 @default.
- W2592393384 creator A5020926082 @default.
- W2592393384 creator A5025183316 @default.
- W2592393384 creator A5053684034 @default.
- W2592393384 creator A5070519976 @default.
- W2592393384 date "2017-03-03" @default.
- W2592393384 modified "2023-10-15" @default.
- W2592393384 title "The vaccinia virus K7 protein promotes histone methylation associated with heterochromatin formation" @default.
- W2592393384 cites W1885727400 @default.
- W2592393384 cites W1934595747 @default.
- W2592393384 cites W1943129326 @default.
- W2592393384 cites W1957143406 @default.
- W2592393384 cites W1966903309 @default.
- W2592393384 cites W1980221962 @default.
- W2592393384 cites W1980224338 @default.
- W2592393384 cites W1987333937 @default.
- W2592393384 cites W1990521726 @default.
- W2592393384 cites W1992974476 @default.
- W2592393384 cites W2005018860 @default.
- W2592393384 cites W2012042594 @default.
- W2592393384 cites W2012116271 @default.
- W2592393384 cites W2014060411 @default.
- W2592393384 cites W2026129690 @default.
- W2592393384 cites W2041250281 @default.
- W2592393384 cites W2043501058 @default.
- W2592393384 cites W2043638973 @default.
- W2592393384 cites W2043950542 @default.
- W2592393384 cites W2044826047 @default.
- W2592393384 cites W2045785776 @default.
- W2592393384 cites W2047018553 @default.
- W2592393384 cites W2048955142 @default.
- W2592393384 cites W2057111361 @default.
- W2592393384 cites W2059172089 @default.
- W2592393384 cites W2059997982 @default.
- W2592393384 cites W2067487392 @default.
- W2592393384 cites W2070607032 @default.
- W2592393384 cites W2071296698 @default.
- W2592393384 cites W2077506542 @default.
- W2592393384 cites W2084885369 @default.
- W2592393384 cites W2088147070 @default.
- W2592393384 cites W2090844684 @default.
- W2592393384 cites W2093189184 @default.
- W2592393384 cites W2094538816 @default.
- W2592393384 cites W2096083625 @default.
- W2592393384 cites W2099540110 @default.
- W2592393384 cites W2099579351 @default.
- W2592393384 cites W2101979023 @default.
- W2592393384 cites W2102247014 @default.
- W2592393384 cites W2102403254 @default.
- W2592393384 cites W2104677263 @default.
- W2592393384 cites W2106073660 @default.
- W2592393384 cites W2106473601 @default.
- W2592393384 cites W2112913464 @default.
- W2592393384 cites W2113411351 @default.
- W2592393384 cites W2121784992 @default.
- W2592393384 cites W2126684428 @default.
- W2592393384 cites W2130437850 @default.
- W2592393384 cites W2132084433 @default.
- W2592393384 cites W2132687886 @default.
- W2592393384 cites W2160804763 @default.
- W2592393384 cites W2168087821 @default.
- W2592393384 cites W2215402383 @default.
- W2592393384 cites W2244390199 @default.
- W2592393384 cites W2394802885 @default.
- W2592393384 cites W3211005720 @default.
- W2592393384 doi "https://doi.org/10.1371/journal.pone.0173056" @default.
- W2592393384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5336242" @default.
- W2592393384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28257484" @default.
- W2592393384 hasPublicationYear "2017" @default.
- W2592393384 type Work @default.
- W2592393384 sameAs 2592393384 @default.
- W2592393384 citedByCount "19" @default.
- W2592393384 countsByYear W25923933842017 @default.
- W2592393384 countsByYear W25923933842019 @default.
- W2592393384 countsByYear W25923933842020 @default.
- W2592393384 countsByYear W25923933842021 @default.
- W2592393384 countsByYear W25923933842022 @default.
- W2592393384 countsByYear W25923933842023 @default.
- W2592393384 crossrefType "journal-article" @default.
- W2592393384 hasAuthorship W2592393384A5002815191 @default.
- W2592393384 hasAuthorship W2592393384A5007171012 @default.
- W2592393384 hasAuthorship W2592393384A5020926082 @default.
- W2592393384 hasAuthorship W2592393384A5025183316 @default.
- W2592393384 hasAuthorship W2592393384A5053684034 @default.
- W2592393384 hasAuthorship W2592393384A5070519976 @default.
- W2592393384 hasBestOaLocation W25923933841 @default.
- W2592393384 hasConcept C103435993 @default.
- W2592393384 hasConcept C104317684 @default.
- W2592393384 hasConcept C150194340 @default.
- W2592393384 hasConcept C153911025 @default.
- W2592393384 hasConcept C159047783 @default.
- W2592393384 hasConcept C190727270 @default.
- W2592393384 hasConcept C22709980 @default.
- W2592393384 hasConcept C2522874641 @default.
- W2592393384 hasConcept C2781356689 @default.