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- W2592415511 abstract "The cover picture shows the chemical structure of HK01, a small molecule that binds the scaffolding protein MO25 and inhibits its binding to SPAK/OSR1 kinases, which subsequently reduces their catalytic activity. Such binding is translated into reduced phosphorylation and manipulation of the activities of a series of sodium, potassium and chloride ion co-transporters, which are normally phosphorylated by the SPAK/OSR1-MO25 protein complex. This represents a novel approach for preventing a protein kinase from binding to its activating protein partner, indirect kinase inhibition. More information can be found in the communication by Y. Mehellou et al. on page 460 in Issue 5, 2017 (DOI: 10.1002/cbic.201600620)." @default.
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- W2592415511 date "2017-02-09" @default.
- W2592415511 modified "2023-09-27" @default.
- W2592415511 title "Cover Picture: Towards the Development of Small-Molecule MO25 Binders as Potential Indirect SPAK/OSR1 Kinase Inhibitors (ChemBioChem 5/2017)" @default.
- W2592415511 doi "https://doi.org/10.1002/cbic.201700042" @default.
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